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  1. 102201
    “…Machine learning approaches showed that genome-wide miRNA profiles and miRNA regulatory networks were quite different between the two outcome groups and mRNA profiles categorized the samples in a manner concordant with the miRNAs, suggesting potential molecular subtypes. …”
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    An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets
  2. 102202
    “…Referred to as the GRADE-ADOLOPMENT approach, it allows guideline developers to follow a structured and transparent process in a more efficient manner, potentially avoiding the need to unnecessarily repeat costly tasks such as conducting systematic reviews. …”
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    A collaborative approach to adopting/adapting guidelines - The Australian 24-Hour Movement Guidelines for the early years (Birth to 5 years): an integration of physical activity, sedentary behavior, and sleep
  3. 102203
    por Nishida, Osamu, Ogura, Hiroshi, Egi, Moritoki, Fujishima, Seitaro, Hayashi, Yoshiro, Iba, Toshiaki, Imaizumi, Hitoshi, Inoue, Shigeaki, Kakihana, Yasuyuki, Kotani, Joji, Kushimoto, Shigeki, Masuda, Yoshiki, Matsuda, Naoyuki, Matsushima, Asako, Nakada, Taka-aki, Nakagawa, Satoshi, Nunomiya, Shin, Sadahiro, Tomohito, Shime, Nobuaki, Yatabe, Tomoaki, Hara, Yoshitaka, Hayashida, Kei, Kondo, Yutaka, Sumi, Yuka, Yasuda, Hideto, Aoyama, Kazuyoshi, Azuhata, Takeo, Doi, Kent, Doi, Matsuyuki, Fujimura, Naoyuki, Fuke, Ryota, Fukuda, Tatsuma, Goto, Koji, Hasegawa, Ryuichi, Hashimoto, Satoru, Hatakeyama, Junji, Hayakawa, Mineji, Hifumi, Toru, Higashibeppu, Naoki, Hirai, Katsuki, Hirose, Tomoya, Ide, Kentaro, Kaizuka, Yasuo, Kan’o, Tomomichi, Kawasaki, Tatsuya, Kuroda, Hiromitsu, Matsuda, Akihisa, Matsumoto, Shotaro, Nagae, Masaharu, Onodera, Mutsuo, Ohnuma, Tetsu, Oshima, Kiyohiro, Saito, Nobuyuki, Sakamoto, So, Sakuraya, Masaaki, Sasano, Mikio, Sato, Norio, Sawamura, Atsushi, Shimizu, Kentaro, Shirai, Kunihiro, Takei, Tetsuhiro, Takeuchi, Muneyuki, Takimoto, Kohei, Taniguchi, Takumi, Tatsumi, Hiroomi, Tsuruta, Ryosuke, Yama, Naoya, Yamakawa, Kazuma, Yamashita, Chizuru, Yamashita, Kazuto, Yoshida, Takeshi, Tanaka, Hiroshi, Oda, Shigeto
    Publicado 2018
    “…CONCLUSIONS: Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals. …”
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    The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)
  4. 102204
    “…The built infrastructure data pertaining to land use, water bodies, roads, railways, community trails, landmarks, water, sanitation and food environment, weather and air quality, and demographic characteristics were constructed in a relational manner. RESULTS: The comprehensive surveillance platform encompassed a population of 0.2 million individuals residing in 51 villages over a land mass of 251.7 sq km having 32,662 households and 19,260 nonresidential features (cattle shed, shops, health, education, banking, religious institutions, etc). …”
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    Online Artículo Texto
    Establishing a Demographic, Development and Environmental Geospatial Surveillance Platform in India: Planning and Implementation
  5. 102205
    “…However, prior to considering these genotypes in a clinically-actionable manner, these findings need independent validation in other studies. …”
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    Online Artículo Texto
    Follicular lymphoma patients with KIR2DL2 and KIR3DL1 and their ligands (HLA-C1 and HLA-Bw4) show improved outcome when receiving rituximab
  6. 102206
    “…We used 3 analytic methods: (1) statistical analysis to provide an overview of loneliness in college students, (2) data mining using the Apriori algorithm to extract behavior patterns associated with loneliness, and (3) machine learning classification to infer the level of loneliness and the change in levels of loneliness using an ensemble of gradient boosting and logistic regression algorithms with feature selection in a leave-one-student-out cross-validation manner. RESULTS: The average loneliness score from the presurveys and postsurveys was above 43 (presurvey SD 9.4 and postsurvey SD 10.4), and the majority of participants fell into the high loneliness category (scores above 40) with 63.8% (102/160) in the presurvey and 58.8% (94/160) in the postsurvey. …”
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    Identifying Behavioral Phenotypes of Loneliness and Social Isolation with Passive Sensing: Statistical Analysis, Data Mining and Machine Learning of Smartphone and Fitbit Data
  7. 102207
    “…The overall compliance rates of the daily PA data collection via the smartphone walking apps and wearable smart bands were analyzed in a within-subject manner. The longitudinal daily collection rates were calculated to examine the dropout pattern. …”
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    An Assessment of Physical Activity Data Collected via a Smartphone App and a Smart Band in Breast Cancer Survivors: Observational Study
  8. 102208
    “…The frequency of weekly SSB consumption differed by family structure in a sex-specific manner: girls from single-parent (β = 3.19 frequency/week, 95% CI: 0.91–5.47, p = 0.006) and boys from blended/adoptive families (β = 3.01 frequency/week, 95% CI: 0.99–5.03, p = 0.004) consumed more SSBs. …”
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    Online Artículo Texto
    A cross-sectional study of obesogenic behaviours and family rules according to family structure in European children
  9. 102209
    “…Tools exist to improve prescription practices and decrease PIP, including screening tools and explicit criteria that can be applied in an automated manner. OBJECTIVE: This study aimed to describe the prevalence of PIP in primary care consultations among patients aged 65-75 years with multimorbidity and polypharmacy, detected by an electronic clinical decision support system (ECDSS) following the 2015 American Geriatrics Society Beers Criteria, the European Screening Tool of Older Person’s Prescription (STOPP), and the Screening Tool to Alert doctors to Right Treatment (START). …”
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    Online Artículo Texto
    Use of an Electronic Clinical Decision Support System in Primary Care to Assess Inappropriate Polypharmacy in Young Seniors With Multimorbidity: Observational, Descriptive, Cross-Sectional Study
  10. 102210
    “…METHODS: In order to better estimate the potential infection risk by tick larvae for humans and animals, 1500 I. ricinus larvae from 50 collected “nests” (larvae adhering to the flag in a clumped manner) were individually examined for Borrelia, Rickettsia and A. phagocytophilum DNA using quantitative real-time PCR (qPCR). …”
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    Online Artículo Texto
    Transovarial transmission of Borrelia spp., Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus under field conditions extrapolated from DNA detection in questing larvae
  11. 102211
    “…BACKGROUND: Silica nanoparticles (nanoSiO(2)) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO(2) has been recently related to abnormal calcium handling and energetic failure in cardiomyocytes. …”
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    Online Artículo Texto
    Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes
  12. 102212
    “…Tregs suppressed the activity of autologous Tresps stimulated with anti-CD3/CD28 beads in a concentration-dependent manner, with the strongest suppression occurring in cocultures with a 1:1 Treg:Tresp ratio in both groups; however, patient-derived Tregs exhibited a poorer capacity to suppress the proliferation of autologous Tresps than the Tregs from normal controls (P < 0.01). …”
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    Online Artículo Texto
    Reduced frequency and functional defects of CD4(+)CD25(high)CD127(low/−) regulatory T cells in patients with unexplained recurrent spontaneous abortion
  13. 102213
    “…BACKGROUND: An infodemic is an overabundance of information—some accurate and some not—that occurs during an epidemic. In a similar manner to an epidemic, it spreads between humans via digital and physical information systems. …”
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    Framework for Managing the COVID-19 Infodemic: Methods and Results of an Online, Crowdsourced WHO Technical Consultation
  14. 102214
    “…Correlation analyses reveal a relationship between litter size and placental outcomes, which were related to fetal outcomes in a sex-dependent manner, suggesting that the placenta may mediate the consequence of LP-Alc-altered litter size on fetal development. …”
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    Online Artículo Texto
    An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational exposure window in a mouse model of FASD
  15. 102215
    “…Furthermore, we identified sets of genes that were affected in TREM2- and APOE isoform-dependent manner. Among them were Clec7a and Csf1r upregulated in APP/E4 vs APP/E3 mice, a result further validated by in situ hybridization analysis. …”
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    Online Artículo Texto
    Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
  16. 102216
    “…Isogenic HCT116 p53-wt/null cancer cells demonstrated that CD276 is induced on the cell surface by Nutlin-3 in a p53-dependent manner. PD-L1 was also unexpectedly induced by Nutlin-3, but PD-L1 does not bind MDM2. …”
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    The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276
  17. 102217
    “…Fortunately, the modifications did not prevent viral viability but influenced replication characteristics of some FMDV mutants in a cell-specific manner, as was shown by the similar replication in BHK-21 cells and delayed growth kinetics in PK-15 cells. …”
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    Modification of the second translation initiation site restricts the replication of foot-and-mouth disease virus in PK-15 cells
  18. 102218
    “…Thereafter, a 23-mm Sapien 3 aortic valve prosthesis (Edwards, Irvine, CA, USA) was implanted via right femoral artery in the usual manner, whereby the arterial pigtail catheter for marking the aortic annulus during transcatheter aortic valve replacement was inserted over a Check-Flo® Hemostasis Assembly (Cook Medical, Bloomington, IN, USA) on a Y-adapter via the arterial extracorporeal membrane oxygenation cannula. …”
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    Protected complex percutaneous coronary intervention and transcatheter aortic valve replacement using extracorporeal membrane oxygenation in a high-risk frail patient: a case report
  19. 102219
    “…In addition, rhEPO and hEPO-MP treatment effectively decreased phosphorylated Smad2 and Smad3, as well as phosphorylated p38 mitogen-activated protein kinase (MAPK) expression, suggesting that rhEPO and rhEPO-MPs can inhibit TGF-β1-induced EMT via both Smad and non-Smad pathways. rhEPO and hEPO-MP treatment also significantly attenuated the extent of renal TIF after 1 week of UUO compared to MOCK-MPs, with hEPO-MPs significantly reducing myofibroblast and F4/80+ macrophage infiltration as well as EMT marker expression in UUO renal tissues in a similar manner to rhEPO. CONCLUSIONS: Our results demonstrate that hEPO-MPs modulate TGF-β1-induced EMT in MDCK cells via the Smad2, Smad3, and p38 MAPK pathways and significantly attenuated renal TIF in UUO kidneys.…”
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    Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis
  20. 102220
    “…RESULTS: We discovered that multiple protein synthesis inhibitors, including RocA, increase TXNIP expression in a manner that depends on MondoA, a functional electron transport chain and mtATP synthesis. …”
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    Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate
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