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  1. 102241
    “…The pandemic has highlighted that new and more flexible clinical trial approaches, such as trial platforms, are needed to assess the efficacy and safety of interventions in a timely manner. The two existing Swiss cohorts of immunocompromised patients (i.e., Swiss HIV Cohort Study (SHCS) and Swiss Transplant Cohort Study (STCS)) are an ideal foundation to set-up a trial platform in Switzerland leveraging routinely collected data. …”
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    A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®
  2. 102242
    “…CONCLUSIONS: Relugolix decreased menstrual blood loss in women with uterine leiomyomas in a dose–response manner, and was generally well tolerated. Clinical trial registration: ClinicalTrials.gov, https://clinicaltrials.gov/ct2/show/NCT01452659, NCT01452659 (registered 17/10/2011); JAPIC Clinical Trial Information, https://www.clinicaltrials.jp, JapicCTI-111590 (registered 31/08/2011). …”
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    Relugolix for oral treatment of uterine leiomyomas: a dose-finding, randomized, controlled trial
  3. 102243
    “…T cell proliferation was significantly decreased in the presence of UC-MSCs in a dose-dependent manner. This inhibitory effect was improved by IFNγ or IFNγ + TNFα, at UC-MSCs:PBMC ratio 1:10 and 1:30, whereas only IFNγ allowed to decrease significantly T cell proliferation at ratio 1:100. …”
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    Development of a human umbilical cord-derived mesenchymal stromal cell-based advanced therapy medicinal product to treat immune and/or inflammatory diseases
  4. 102244
    “…Time-course profiling of fatty acids and complex lipids during cell reprogramming using lipidomics revealed a profound remodelling of the lipid content, as well as the saturation and length of their acyl chains, in a c-MYC-dependent manner. Pluripotent cells displayed abundant cardiolipins and scarce phosphatidylcholines, with a prevalence of monounsaturated acyl chains. …”
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    c-MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency
  5. 102245
    “…RESULTS: Intracellular reactive oxygen species production, an inflammatory response, and morphological activation of cells were greater, but glucose uptake was lower in MNPs@SiO(2)(RITC)-treated BV2 microglia and primary rat microglia in a dose-dependent manner. Expression of 121 genes (from 41,214 identified genes), and levels of 45 proteins (from 5918 identified proteins) and 17 metabolites (from 47 identified metabolites) related to the above phenomena changed in MNPs@SiO(2)(RITC)-treated microglia. …”
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    Silica-coated magnetic-nanoparticle-induced cytotoxicity is reduced in microglia by glutathione and citrate identified using integrated omics
  6. 102246
    “…The addition of TNFα to NSC34 cells caused cPLA(2)α upregulation in a dose dependent manner. CONCLUSIONS: Motor neurons expressing elevated cPLA(2)α and TNFα are in an inflammatory state as early as at 6 weeks old mutant SOD1(G93A) mice long before the development of the disease. …”
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    Early upregulation of cytosolic phospholipase A(2)α in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis
  7. 102247
    “…Secondly, we demonstrated that visual scores for root biomass were correlated with root dry weight (r = 0.72), indicating that single plants could be evaluated for root biomass in a non-destructive manner. To highlight the potential of the approach, we applied SPS in a backcrossing program which integrated MAS and speed breeding for the purpose of rapidly modifying the root system of elite bread wheat line Borlaug100. …”
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    A toolkit to rapidly modify root systems through single plant selection
  8. 102248
    “…Mechanistically, our functional assays indicated that TFEB promoted EC cell migration in an ERRα-dependent manner via EMT signaling. Consistent with the in vitro, higher PC (18:1/18:2) + HCOO was found in EC patients, and those with higher TFEB/ERRα had deeper myometrial invasion and lower serum HDL levels. …”
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    Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression
  9. 102249
    “…The mean area under the effect-time curve (AUEC(last)) and maximum serum concentration of both absolute neutrophil count (ANC(max)) and CD34(+) cell count (CD34(+)(max)) increased in a dose-dependent manner. There were no significant adverse events attributable to eflapegrastim or pegfilgrastim in both Japanese and Caucasian subjects. …”
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    A Randomized, Double-Blind, Placebo- and Active-Controlled, Escalating Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Subcutaneous Eflapegrastim in Healthy Japanese and Caucasian Subjects
  10. 102250
    “…Utilizing transcriptome wide protein occupancy map generated using POP-seq in HeLa cells against publicly available protein-RNA interaction map in Hek293 cells, we show that CASowary can predict high quality guides for numerous transcripts in a cell line specific manner. CONCLUSIONS: Application of CASowary to whole transcriptomes should enable rapid deployment of CRISPR/Cas13 systems, facilitating the development of therapeutic interventions linked with aberrations in RNA regulatory processes. …”
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    CASowary: CRISPR-Cas13 guide RNA predictor for transcript depletion
  11. 102251
    “…We found that MgIG improved hepatomegaly and reduced the incidence of steatosis in a dose-dependent manner by oil red O staining and diminished deposits of alcohol-induced fat droplets by histologic analysis. …”
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    Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress
  12. 102252
    “…Future studies are needed to better understand the difference in retention, preferable in a prospective manner. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-022-13025-y.…”
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    Retention on antiretroviral therapy in person with HIV and viral hepatitis coinfection in Ethiopia: a retrospective cohort study
  13. 102253
    “…Exercise mitigated aberrant Ca(2+) handling, mitochondrial homeostasis, and increased oxidative and nitrosative stress in a manner that correlated with improved skeletal muscle function after radiation. …”
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    Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress
  14. 102254
    “…CONCLUSION: PC-3-DsRed cells preferentially populated bones in mice that had received hBMSC-Luc/GFP, although PC-3-DsRed cells not specifically localize in the bone marrow cavity where hBMSC-Luc/GFP had been transplanted. hBMSC-Luc/GFP appear to modify mouse biology in a manner that supports PC-3-DsRed tumor development, rather than specifically influencing PC-3-DsRed cell homing. …”
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    Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs
  15. 102255
    “…The selection of studies, data extraction, assessment of the risk of bias, and the quality of evidence will be carried out in a paired and independent manner, and the consistency will be assessed using the statistics of Cohen Kappa. …”
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    The effects of exercise on circulating endocannabinoid levels—a protocol for a systematic review and meta-analysis
  16. 102256
    “…This highly efficient medium enabled the rapid expansion of hiPSCs in a reliable and cost-effective manner and could act as a promising tool for disease modeling and large-scale production for regenerative medicine in the future. …”
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    Development and evaluation of a novel xeno-free culture medium for human-induced pluripotent stem cells
  17. 102257
    “…CONCLUSION: GAA supplementation did not altered pig growth performance, but it altered plasma and tissue free amino acid profiles and the contents of related metabolites in pigs in a tissue-dependent manner.…”
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    Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs
  18. 102258
    “…RESULTS: We show that TL8-506 synergized with IFN-γ or Poly(I:C) to induce high expression of different chemokines and cytokines including interleukin (IL)-12p70 in human cord blood and blood cDC subsets in a combination-specific manner. Importantly, both combinations induced the activation of cDC subsets in patient tumor samples ex vivo. …”
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    Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells
  19. 102259
    “…BACKGROUND: Recent studies have demonstrated that T cells can induce vasodilation in a choline-acetyltransferase dependent manner, leading to an increase in T cell migration to infected tissues in response to viral infection, but its role in cancer is unclear. …”
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    Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab
  20. 102260
    “…Snus exposure, perceived as “safe” by users, before or during pregnancy seems to affect midpregnancy placental health in a sex dimorphic manner. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13293-022-00443-1.…”
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    The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers
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