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  1. 102261
    “…Interestingly, these seemingly contradictory events may have occurred in a cAMP-dependent manner. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12958-022-00970-x.…”
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    Diverse actions of sirtuin-1 on ovulatory genes and cell death pathways in human granulosa cells
  2. 102262
    “…CONCLUSIONS: Encouraging results suggest that the integration of wearable cameras and deep learning approaches can provide objective contextual information in an automated manner, towards context-aware FLDBs for gait and fall risk assessment in the wild. …”
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    Egocentric vision-based detection of surfaces: towards context-aware free-living digital biomarkers for gait and fall risk assessment
  3. 102263
    por Eissman, Jaclyn M, Dumitrescu, Logan, Mahoney, Emily R, Smith, Alexandra N, Mukherjee, Shubhabrata, Lee, Michael L, Scollard, Phoebe, Choi, Seo Eun, Bush, William S, Engelman, Corinne D, Lu, Qiongshi, Fardo, David W, Trittschuh, Emily H, Mez, Jesse, Kaczorowski, Catherine C, Hernandez Saucedo, Hector, Widaman, Keith F, Buckley, Rachel F, Properzi, Michael J, Mormino, Elizabeth C, Yang, Hyun Sik, Harrison, Theresa M, Hedden, Trey, Nho, Kwangsik, Andrews, Shea J, Tommet, Douglas, Hadad, Niran, Sanders, R Elizabeth, Ruderfer, Douglas M, Gifford, Katherine A, Zhong, Xiaoyuan, Raghavan, Neha S, Vardarajan, Badri N, Pericak-Vance, Margaret A, Farrer, Lindsay A, Wang, Li San, Cruchaga, Carlos, Schellenberg, Gerard D, Cox, Nancy J, Haines, Jonathan L, Keene, C Dirk, Saykin, Andrew J, Larson, Eric B, Sperling, Reisa A, Mayeux, Richard, Cuccaro, Michael L, Bennett, David A, Schneider, Julie A, Crane, Paul K, Jefferson, Angela L, Hohman, Timothy J
    Publicado 2022
    “…With these phenotypes, we performed sex-stratified [n (males) = 2093, n (females) = 2931] and sex-interaction [n (both sexes) = 5024] genome-wide association studies (GWAS), gene and pathway-based tests, and genetic correlation analyses to clarify the variants, genes and molecular pathways that relate to resilience in a sex-specific manner. Estimated among cognitively normal individuals of both sexes, resilience was 20–25% heritable, and when estimated in either sex among cognitively normal individuals, resilience was 15–44% heritable. …”
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    Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease
  4. 102264
    “…These results support testing cervical strength in this manner to reliably assess change over time within individual patients. …”
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    A clinical test to assess isometric cervical strength in chronic whiplash associated disorder (WAD): a reliability study
  5. 102265
    “…RESULTS: Unlike CD16-CAR T cells, which bind human IgG in a non-selective manner, P329G-targeting CAR T cells revealed specific effector functions only when combined with antibodies carrying P329G LALA mutations in their Fc part. …”
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    Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors
  6. 102266
    “…PSEN1 p.Ile414Thr did not alter Aβ in a manner consistent with a known pathogenic mutation. …”
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    Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America
  7. 102267
    “…When software is coupled with automation, we can engage with research participants in a reliable and affordable manner. Research Electronic Data Capture (REDCap), a browser-based software, has the capability to send automated text messages. …”
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    A Method to Deliver Automated and Tailored Intervention Content: 24-month Clinical Trial
  8. 102268
    “…Thus, there is a high demand for a novel method that can predict “low-risk and high-potency clones” early and in a feasible manner given the excessive cost and effort required to maintain such an establishment. …”
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    Morphology-based noninvasive early prediction of serial-passage potency enhances the selection of clone-derived high-potency cell bank from mesenchymal stem cells
  9. 102269
    “…Absence of SLAMF7 did not grossly alter the CNS immune landscape, but allowed for altered immune cell subset infiltration during EAE in a model-dependent manner. Global lack of SLAMF7 expression increased myeloid cell activation states along with augmented T cell anti-MOG immunity. …”
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    SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity
  10. 102270
    por Sedilla, Keneth B., Maeda, Takafumi
    Publicado 2022
    “…Collectively, the results of this study appear to support the hypothesis that the temporal recruitment of autonomic thermoeffectors follows an orderly manner based on their physiological cost.…”
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    Autonomic thermoregulatory responses and subjective thermal perceptions upon the initiation of thermal behavior among resting humans in hot and humid environment
  11. 102271
    “…We found that outpatient SARS-CoV-2 variant surveillance could be conducted in a timely and accurate manner. The prevalence of different variants changed over time. …”
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    Local monitoring of SARS-CoV-2 variants in two large California counties in 2021
  12. 102272
    por Mohammed Taha, Hiba, Aalizadeh, Reza, Alygizakis, Nikiforos, Antignac, Jean-Philippe, Arp, Hans Peter H., Bade, Richard, Baker, Nancy, Belova, Lidia, Bijlsma, Lubertus, Bolton, Evan E., Brack, Werner, Celma, Alberto, Chen, Wen-Ling, Cheng, Tiejun, Chirsir, Parviel, Čirka, Ľuboš, D’Agostino, Lisa A., Djoumbou Feunang, Yannick, Dulio, Valeria, Fischer, Stellan, Gago-Ferrero, Pablo, Galani, Aikaterini, Geueke, Birgit, Głowacka, Natalia, Glüge, Juliane, Groh, Ksenia, Grosse, Sylvia, Haglund, Peter, Hakkinen, Pertti J., Hale, Sarah E., Hernandez, Felix, Janssen, Elisabeth M.-L., Jonkers, Tim, Kiefer, Karin, Kirchner, Michal, Koschorreck, Jan, Krauss, Martin, Krier, Jessy, Lamoree, Marja H., Letzel, Marion, Letzel, Thomas, Li, Qingliang, Little, James, Liu, Yanna, Lunderberg, David M., Martin, Jonathan W., McEachran, Andrew D., McLean, John A., Meier, Christiane, Meijer, Jeroen, Menger, Frank, Merino, Carla, Muncke, Jane, Muschket, Matthias, Neumann, Michael, Neveu, Vanessa, Ng, Kelsey, Oberacher, Herbert, O’Brien, Jake, Oswald, Peter, Oswaldova, Martina, Picache, Jaqueline A., Postigo, Cristina, Ramirez, Noelia, Reemtsma, Thorsten, Renaud, Justin, Rostkowski, Pawel, Rüdel, Heinz, Salek, Reza M., Samanipour, Saer, Scheringer, Martin, Schliebner, Ivo, Schulz, Wolfgang, Schulze, Tobias, Sengl, Manfred, Shoemaker, Benjamin A., Sims, Kerry, Singer, Heinz, Singh, Randolph R., Sumarah, Mark, Thiessen, Paul A., Thomas, Kevin V., Torres, Sonia, Trier, Xenia, van Wezel, Annemarie P., Vermeulen, Roel C. H., Vlaanderen, Jelle J., von der Ohe, Peter C., Wang, Zhanyun, Williams, Antony J., Willighagen, Egon L., Wishart, David S., Zhang, Jian, Thomaidis, Nikolaos S., Hollender, Juliane, Slobodnik, Jaroslav, Schymanski, Emma L.
    Publicado 2022
    “…CONCLUSIONS: The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. …”
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    The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry
  13. 102273
    “…On the one hand, NO produced by MDSCs enhanced aerobic glycolysis in a positive feedback manner. On the other hand, C. tropicalis promotes p-Syk binding to PKM2, which results in PKM2 Tyr105 phosphorylation and PKM2 nuclear translocation in MDSCs. …”
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    Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis
  14. 102274
    “…We also systematically searched and evaluated endoscopically treated T1RC patients in a similar manner. RESULTS: In 2585 unique T1RC patients (86 studies) undergoing local surgical resection, the overall pooled cumulative incidence of recurrence was 9.1% (302 events, 95% CI 7.3–11.4%; I(2) = 68.3%). …”
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    Risk of recurrence after local resection of T1 rectal cancer: a meta-analysis with meta-regression
  15. 102275
    “…CONCLUSION: Culture, origin, language barrier and companionship during labour influences the manner in which women in labour express their pain. …”
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    Cultural influence on the expression of labour-associated pain
  16. 102276
    “…CONCLUSIONS: ECV19 was generally well-tolerated and induced antibodies in a dose-dependent manner that neutralized SARS-CoV-2. The unique liposome display approach of ECV19, which lacks any immunogenic protein components besides the antigen itself, coupled with the lack of increased adverse events during boosting suggest the vaccine platform may be amenable to multiple boosting regimes in the future. …”
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    Interim analysis from a phase 2 randomized trial of EuCorVac-19: a recombinant protein SARS-CoV-2 RBD nanoliposome vaccine
  17. 102277
    “…YAP governs adaptive resistance to RAF kinase inhibitors and induces a gene expression program in BRAF(V600E)-mutant cells encompassing effectors in the NRG1 signaling pathway, which play a central role in the insensitivity to MAPK inhibitors in a lineage-dependent manner. HIPPO pathway inactivation serves as a lineage-dependent rheostat controlling the magnitude of the adaptive relief of feedback responses to MAPK inhibitors in BRAF-(V600E) cancers. …”
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    Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors
  18. 102278
    “…Finally, we studied whether human LOTUS protein inhibits Aβ binding to LilrB2, a human homolog of PirB, and found that human LOTUS inhibited the binding of Aβ to LilrB2 in a similar manner. CONCLUSIONS: This study implied that LOTUS improved Aβ-induced synapse elimination by suppressing Aβ-PirB interaction in rodents and inhibited Aβ–LilrB2 interaction in humans. …”
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    LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB
  19. 102279
    “…Ceramide upregulated the expression of thioredoxin interacting protein (TXNIP), NLRP3, GSDMD, GSDMD-NT, caspase-1 and Casp1 p20 at the protein and mRNA level in a dose-dependent manner. It also enhanced the PI uptake in HUVECs and upregulated caspase-1 activity. …”
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    Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs
  20. 102280
    “…Moreover, plasminogen (Plg)- and fibronectin (Fn)-binding assays demonstrated that rMSNOX bound Plg and Fn in a dose-dependent manner, thereby further confirming that MSNOX may be a putative adhesin. …”
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    NADH oxidase of Mycoplasma synoviae is a potential diagnostic antigen, plasminogen/fibronectin binding protein and a putative adhesin
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