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  1. 102321
    “…Very high ACTH levels reduce PD-L2 and leptin in a glucocorticoid-independent manner, although the overall effect on biomarker profiles seems small. …”
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    SAT285 Biomarkers For Cardiovascular Disease And Inflammation Are Altered In Autoimmune Addison's Disease
  2. 102322
    “…Here, we show that PRL modifies in an opposite manner the inflammatory action of IL-1β and TNF-α in mouse synovial fibroblasts (SF) in culture and in joints in vivo. …”
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    FRI295 Prolactin Exerts Anti- And Pro-inflammatory Actions In Joint Tissues That Are Cytokine-Dependent
  3. 102323
    “…These findings suggest that Adgrl1(VMH) is essential in regulating energy and glucose homeostasis in a sex-specific manner. Moreover, Adgrl1(VMH) contributes to leptin’s acute effects on food intake. …”
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    OR12-06 Hypothalamic Adgrl1 Is A Potential Glucoreceptor Involved In Regulating Energy Balance, Glucose Homeostasis, And Leptin Sensitivity In Mice
  4. 102324
    “…While in the majority, it is inherited in an X-linked manner, at least 4.1% of individuals with X-ALD have a de novo pathogenic variant of ABCD1. …”
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    SAT315 A Case Of PAI "Do Not Miss This Rare Cause"
  5. 102325
    “…Solid fuel for heating had a significant correlation with low muscle strength (adjusted OR = 1.30, 95% CI: 1.09, 1.56, P < 0.01 in model 3) and possible sarcopenia (adjusted OR = 1.49, 95% CI: 1.31, 1.70, P < 0.01 in model 3). Dose‐dependent manner was shown in the associations between the number of solid fuel with low muscle strength and possible sarcopenia. …”
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    Associations between indoor air pollution for cooking and heating with muscle and sarcopenia in Chinese older population
  6. 102326
    “…Future studies to identify changes in these regulators in a cell-specific manner could lead to the development of novel targeted therapies for ASH.…”
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    Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies
  7. 102327
    “…Compared with control group (DMEM/F-12 medium alone), the high dose PFHF can significantly reduce the viability, migration, and invasion of HEcESCs, increase the apoptosis rate of HEcESCs, and make the HEcESCs accumulated in G0/G1 phase in a time- and dose-dependent manner (p < 0.05). The analysis of label-free quantitative proteomics indicated that PFHF flavonoids may induce apoptosis of EESCs through PI3K/AKT signaling pathway. …”
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    Total Flavonoids of Polygala fallax Hemsl Induce Apoptosis of Human Ectopic Endometrial Stromal Cells through PI3K/AKT/Bcl-2 Signaling Pathway
  8. 102328
    “…A suitable analysis tool for the benchmark results is provided via a mixed model approach, which showed for our study on patients with intrahepatic liver metastases, that radiomics features captured the patients' clinical situation in a manner comparable to the provided information solely from clinical parameters. …”
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    A Comprehensive Machine Learning Benchmark Study for Radiomics-Based Survival Analysis of CT Imaging Data in Patients With Hepatic Metastases of CRC
  9. 102329
    “…CONCLUSION: The finding that 78% of children diagnosed with UHL at birth had a decrease in hearing loss between the hearing levels at first diagnosis and their first behavioural audiogram highlights the importance of monitoring hearing threshold levels after diagnosis, so that appropriate intervention can be implemented in a timely manner. For clinical management, deterioration of 15 dB at one or more frequencies that does not recover warrants action.…”
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    Audiological characteristics of children with congenital unilateral hearing loss: insights into Age of reliable behavioural audiogram acquisition and change of hearing loss
  10. 102330
    “…BACKGROUND: The adaptive immune system is known to be responsible for maintain long-term immune memory in an antigen-specific manner. However, recent studies have shown that in chronic infections such as CMV, HCV, and HIV, long-lasting modifications can occur in immune cells without antigen specificity. …”
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    259. Long-term Transcriptomic Changes in the CD4 T cells Following Treatment of Extrapulmonary Tuberculosis
  11. 102331
    “…With over 9.8 million cancer survivors (defined as anyone living with cancer) in the United States alone and the number growing worldwide, it is important to understand how they seek and use online resources to obtain the information they need, when they need it, and in a form and manner appropriate to them. These are stated cancer communication goals of the US National Cancer Institute. …”
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    How New Subscribers Use Cancer-Related Online Mailing Lists
  12. 102332
    por Cunningham, R. H.
    Publicado 1898
    “…Still less capable are the thyroid preparations containing decomposition products. (11) The presence of one, or usually several, small accessory thyroid bodies, which gradually hypertrophy and wholly or partially assume the functions of the excised thyroid lobes, accounts for the occasionally long survival of thyroidectomized, thyroid-fed, young dogs. (12) Totally thyroidless young dogs are so quickly overwhelmed by the cachexia, and the intervals between the thyroidectomy and the onset of the severe dyspnœic attacks and subsequent deaths differ so slightly, no matter which of the usual varieties of fresh food are employed, that kinds of fresh food cannot be unquestionably affirmed to influence the onset of the cachexia in any especially definite manner. Animal foods, in which constituents poisonous to rabbits have developed, probably slightly hasten the onset of the severer symptoms, and the vaunted remarkably modifying influence of a diet of ordinary milk, such as Breisacher observed, does not exist in the case of the totally thyroidless dog. (13) Monkeys whose general metabolism is disturbed in consequence of the removal of a greater portion of the thyroid gland, evidently become more susceptible to those constituents of meat that are poisonous to rabbits, and sufficient clinical evidence exists for concluding that probably a like susceptibility to animal foods containing such constituents also exists in men when the function of the thyroid gland is sufficiently disturbed. (14) And, finally, as regards the thyroid factor in the pathology of exophthalmic goitre, I agree with Gley that the majority of the symptoms in many patients with that disease can apparently, from an experimental standpoint, be as plausibly explained by the hypothesis of partially deficient thyroid activity as by the hypothesis of augmentation of thyroid function.…”
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    EXPERIMENTAL THYROIDISM
  13. 102333
    “…The resistance which was demonstrable when the virus was instilled intranasally on the 4th and 6th days after the beginning of treatment was also found to be present a week later when the treatments were given daily, indicating that the refractory state can be maintained in this manner. It was observed, however, that monkeys which were given nasal instillations of alum or tannic acid for 5 days or more may retain the resistance they acquired for 1 or 2 months without any additional treatment (Table V); thus, of 15 refractory monkeys retested after 1 month, 11 were still resistant; seven of 15 monkeys were refractory when retested after 2 months, while only one of 11 failed to develop poliomyelitis after an interval of 3 months. …”
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    PROTECTIVE ACTION OF CERTAIN CHEMICALS AGAINST INFECTION OF MONKEYS WITH NASALLY INSTILLED POLIOMYELITIS VIRUS
  14. 102334
    por Zinsser, Hans, Tang, Fei-Fang
    Publicado 1926
    “…By the inoculation of very small doses or by infection of partially immunized rabbits, as described above, we have succeeded in modifying the characteristic herpetic syndrome in rabbits in a manner which simulates many of the clinical features of human encephalitis. …”
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    IMMUNOLOGICAL STUDIES WITH HERPES VIRUS WITH A CONSIDERATION OF THE HERPES-ENCEPHALITIS PROBLEM
  15. 102335
    “…Post-infusion total plasma levels of topotecan declined in a biphasic manner with a terminal half-life of 2.1 +/- 0.3 h. …”
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    Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide.
  16. 102336
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    A molecular phylogenetic reappraisal of the Hysteriaceae, Mytilinidiaceae and Gloniaceae (Pleosporomycetidae, Dothideomycetes) with keys to world species
  17. 102337
    “…However, exposing cows to bull in this manner altered characteristics of temporal patterns of both LH and cortisol by increasing LH pulse frequency and decreasing cortisol pulse frequency. …”
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    Characteristics of temporal patterns of cortisol and luteinizing hormone in primiparous, postpartum, anovular, suckled, beef cows exposed acutely to bulls
  18. 102338
    “…Proper health information on the rational use of ant-malarial drugs must be provided in an appropriate manner to all groups of people in the society including village health workers, women associations, churches, school children, “Mngwah” opinion leaders, herbalists, health workers and chemists. …”
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    Knowledge and practices relating to malaria in a semi-urban area of Cameroon: choices and sources of antimalarials, self-treatment and resistance
  19. 102339
    “…RESULTS: HIV-1(YU-2)-transfection significantly increased CD38 mRNA and protein expression in astrocytes (p < 0.01) in a dose-dependent manner and induced astrocyte activation. IL-β-activation of HIV-1(YU-2)-transfected astrocytes significantly increased HIV-1 gene expression (p < 0.001). …”
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    HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms
  20. 102340
    por Hawksworth, David L., Crous, Pedro W., Redhead, Scott A., Reynolds, Don R., Samson, Robert A., Seifert, Keith A., Taylor, John W., Wingfield, Michael J., Abaci, Özlem, Aime, Catherine, Asan, Ahmet, Bai, Feng-Yan, de Beer, Z. Wilhelm, Begerow, Dominik, Berikten, Derya, Boekhout, Teun, Buchanan, Peter K., Burgess, Treena, Buzina, Walter, Cai, Lei, Cannon, Paul F., Crane, J. Leland, Damm, Ulrike, Daniel, Heide-Marie, van Diepeningen, Anne D., Druzhinina, Irina, Dyer, Paul S., Eberhardt, Ursula, Fell, Jack W., Frisvad, Jens C., Geiser, David M., Geml, József, Glienke, Chirlei, Gräfenhan, Tom, Groenewald, Johannes Z., Groenewald, Marizeth, de Gruyter, Johannes, Guého-Kellermann, Eveline, Guo, Liang-Dong, Hibbett, David S., Hong, Seung-Beom, de Hoog, G. Sybren, Houbraken, Jos, Huhndorf, Sabine M., Hyde, Kevin D., Ismail, Ahmed, Johnston, Peter R., Kadaifciler, Duygu G., Kirk, Paul M., Kõljalg, Urmas, Kurtzman, Cletus P., Lagneau, Paul-Emile, Lévesque, C. André, Liu, Xingzhong, Lombard, Lorenzo, Meyer, Wieland, Miller, Andrew, Minter, David W., Najafzadeh, Mohammad Javad, Norvell, Lorelei, Ozerskaya, Svetlana M., Öziç, Rasime, Pennycook, Shaun R., Peterson, Stephen W., Pettersson, Olga V., Quaedvlieg, William, Robert, Vincent A., Ruibal, Constantino, Schnürer, Johan, Schroers, Hans-Josef, Shivas, Roger, Slippers, Bernard, Spierenburg, Henk, Takashima, Masako, Taşkın, Evrim, Thines, Marco, Thrane, Ulf, Uztan, Alev Haliki, van Raak, Marcel, Varga, János, Vasco, Aida, Verkley, Gerard, Videira, Sandra I.R., de Vries, Ronald P., Weir, Bevan S., Yilmaz, Neriman, Yurkov, Andrey, Zhang, Ning
    Publicado 2011
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    The Amsterdam Declaration on Fungal Nomenclature
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