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102341por Yang, Xinxin, Zheng, Ruiyuan, Cai, Yunpeng, Liao, Meiling, Yuan, Weien, Liu, Zhenguo“…METHODS: In this study, we prepared levodopa methyl ester (LDME)/benserazide-loaded nanoparticles, which can release LDME and benserazide in a sustained manner. Dyskinesia was induced in rats by repeated administration of levodopa then treated with LDME plus benserazide or the same dose of LDME/benserazide-loaded nanoparticles. …”
Publicado 2012
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102343por Lantow, Margareta, Sivakumar, Ramya, Zeumer, Leilani, Wasserfall, Clive, Zheng, Ying-Yi, Atkinson, Mark A, Morel, Laurence“…G-CSF treatment restored the ability of B6.Sle2c2 mice to produce autoantibodies in a dose-dependent manner upon cGVHD induction, which correlated with restored CD4(+ )T cells activation, as well as dendritic cell and granulocyte expansion. …”
Publicado 2013
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102344por Xie, Jian-Hui, Chen, Yun-Long, Wu, Qing-He, Wu, Jun, Su, Ji-Yan, Cao, Hong-Yin, Li, Yu-Cui, Li, Yi-Sheng, Liao, Jin-Bin, Lai, Xiao-Ping, Huang, Ping, Su, Zi-Ren“…RESULTS: In the HCl/Ethanol-induced ulcer model, it was observed that oral administration with HZJW (260, 520 and 1040 mg/kg) and ranitidine (250 mg/kg) significantly reduced the ulcerative lesion index (116.70 ± 36.4, 102.20 ± 18.20, 84.10 ± 12.1 and 73.70 ± 16.70) in a dose-dependent manner, respectively, with respect to control group (134.10 ± 31.69). …”
Publicado 2013
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102345“…Finally, public health and water utility representatives from several of the WSi pilots acknowledged that their automated surveillance tools currently have limited capabilities for detection of chemical contaminants (which may result in a sudden onset of symptoms), with the main deficiency being the timeliness of the alerts relative to the window of opportunity to respond in a meaningful and effective manner. While they currently focus on detection of traditional waterborne diseases, these tools could potentially be adapted to also detect chemical contaminants. …”
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102346por Allen, Ann“…The measurement of 24-h serum cortisol and 24-h urinary cortisol excretion are sensitive methods for assessing adrenocortical activity, and can evaluate cortisol suppression in a dose-dependent manner. OBJECTIVE: The purpose of the meta-analysis presented here was to characterize the population pharmacokinetic/pharmacodynamic relationship between fluticasone furoate systemic exposure [as measured by area under the concentration–time curve over 24 h postdose (AUC(24))] and both 24-h weighted mean serum cortisol (WM24) and 24-h urine cortisol excretion in healthy subjects and subjects with asthma. …”
Publicado 2013
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102347“…More important is GCI's primary goal to motivate as many people as possible to work together in a more coherent and collaborative manner to increase the collective human consciousness. …”
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102348“…Crowdsourcing permitted a carefully designed comparative search-interface evaluation to be completed in a timely and cost-effective manner with a relatively large number of participants recruited anonymously. …”
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102349“…The findings of this review suggest that the etiology of ASD may involve, at least in a subset of children, complex interactions between genetic factors and certain environmental toxicants that may act synergistically or in parallel during critical periods of neurodevelopment, in a manner that increases the likelihood of developing ASD. …”
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102350por Oliver, Jonathan M, Jagim, Andrew R, Pischel, Ivo, Jäger, Ralf, Purpura, Martin, Sanchez, Adam, Fluckey, James, Riechman, Steven, Greenwood, Michael, Kelly, Katherine, Meininger, Cynthia, Rasmussen, Christopher, Kreider, Richard B“…METHODS: In a double-blind, randomized, and crossover manner; 10 recreationally trained males (20 ± 2 yrs; 179 ± 9 cm; 91.3 ± 34 kg) ingested 500 mg of aqueous RT extract (Finzelberg, Andernach, Germany) or 500 mg placebo 30-minutes prior to ingesting 5 g of CrM (Creapure®, AlzChem AG, Germany) twice per day for 5-days then repeated after a 6-week wash-out period. …”
Publicado 2014
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102351por Ilakkuvan, Vinu, Tacelosky, Michael, Ivey, Keith C, Pearson, Jennifer L, Cantrell, Jennifer, Vallone, Donna M, Abrams, David B, Kirchner, Thomas R“…This can be determined in a systematic manner based on the difficulty of the task and the desired level of accuracy, using receiver operating characteristic (ROC) analyses. …”
Publicado 2014
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102352por Majid, Tabassum, Ali, Yousuf O., Venkitaramani, Deepa V., Jang, Ming-Kuei, Lu, Hui-Chen, Pautler, Robia G.“…RESULTS: Using the MEMRI technique on 1.5, 3, 5, and 10-month old rTg4510 mice and littermate controls, we found significant axonal transport deficits present in the rTg4510 mice beginning at 3 months of age in an age-dependent manner. Using linear regression analysis, we measured rates of axonal transport at 1.5, 3, 5, and 10 months of age in rTg4510 and WT mice. …”
Publicado 2014
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102353por Bago, Ruzica, Malik, Nazma, Munson, Michael J., Prescott, Alan R., Davies, Paul, Sommer, Eeva, Shpiro, Natalia, Ward, Richard, Cross, Darren, Ganley, Ian G., Alessi, Dario R.“…Monitoring SGK3 phosphorylation and activity could be employed as a biomarker of Vps34 activity, in an analogous manner by which Akt is used to probe cellular class I PI3K activity. …”
Publicado 2014
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102354“…CONCLUSIONS: The system introduced in this article shows that current LOD technologies are a promising alternative to represent heterogeneous health data in a flexible and reusable manner so that they can serve intelligent queries, and ultimately support decision-making. …”
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102355por Crous, P.W., Wingfield, M.J., Schumacher, R.K., Summerell, B.A., Giraldo, A., Gené, J., Guarro, J., Wanasinghe, D.N., Hyde, K.D., Camporesi, E., Gareth Jones, E.B., Thambugala, K.M., Malysheva, E.F., Malysheva, V.F., Acharya, K., Álvarez, J., Alvarado, P., Assefa, A., Barnes, C.W., Bartlett, J.S., Blanchette, R.A., Burgess, T.I., Carlavilla, J.R., Coetzee, M.P.A., Damm, U., Decock, C.A., den Breeÿen, A., de Vries, B., Dutta, A.K., Holdom, D.G., Rooney-Latham, S., Manjón, J.L., Marincowitz, S., Mirabolfathy, M., Moreno, G., Nakashima, C., Papizadeh, M., Shahzadeh Fazeli, S.A., Amoozegar, M.A., Romberg, M.K., Shivas, R.G., Stalpers, J.A., Stielow, B., Stukely, M.J.C., Swart, W.J., Tan, Y.P., van der Bank, M., Wood, A.R., Zhang, Y., Groenewald, J.Z.Enlace del recurso
Publicado 2014
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102356“…Rotavirus (RV), a major cause of pediatric gastroenteritis, can block NF-κB activation through the action of its nonstructural protein NSP1, a putative E3 ubiquitin ligase that mediates the degradation of β-TrCP or other immunomodulatory proteins in a virus strain-specific manner. Here, we show that NSP1 targets β-TrCP by mimicking the IκB phosphodegron. …”
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102357por Krutilina, Raisa, Sun, Wenlin, Sethuraman, Aarti, Brown, Martin, Seagroves, Tiffany N, Pfeffer, Lawrence M, Ignatova, Tatyana, Fan, Meiyun“…Modulating miR-18a expression significantly affected hypoxic gene expression, cell invasiveness and sensitivity to anoikis and hypoxia in vitro in a HIF1A-dependent manner. Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxic genes is associated with shorter DMFS interval in patients with basal-like breast tumors, and that, within this subtype, miR-18a expression is inversely correlated with hypoxic gene expression. …”
Publicado 2014
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102358“…Rather than evaluating traffic/transportation noise, the method focuses on the consideration of the noise level and its impact on human health, regardless of the source producing the noise in an analogous manner as considered in the fields of toxicology and common noise evaluation practices combined. …”
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102359por Jayasena, C.N., Abbara, A., Narayanaswamy, S., Comninos, A.N., Ratnasabapathy, R., Bassett, P., Mogford, J.T., Malik, Z., Calley, J., Ghatei, M.A., Bloom, S.R., Dhillo, W.S.“…Our data suggest that kisspeptin stimulates gonadotrophin secretion less potently when compared with GnRH; however, kisspeptin may stimulate gonadotrophins in a more physiological manner when compared with current therapies. Kisspeptin is emerging as a future therapeutic agent, so it is important to establish which kisspeptin hormones could be used to treat patients with infertility. …”
Publicado 2015
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102360“…BACKGROUND: The NF-kB signaling, regulated by IKK1-p52/RelB and IKK2-p65, is activated by various stresses to protect or damage the liver, in context-specific manners. Two previous studies of liver-specific expression of constitutive active IKK2 (IKK2ca) showed that strong activation of IKK2-NF-kB in mouse livers caused inflammation, insulin resistance, and/or fibrosis. …”
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