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  1. 102381
    “…RESULTS: Western blot analysis revealed that Hb-treatment resulted in the detection of ADAMTS-5 and -9 proteins in a dose-, and time-dependent manner. Neither control nor Hb-treated medium showed immunoreactivity against anti-ADAMTS-8, and -10 IgG. …”
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    Hemoglobin Stimulates the Expression of Adamts-5 and -9 by Synovial Cells; A Possible Cause of Cartilage Damage after Intra-articular Bleeding
  2. 102382
    “…Facebook is the most used social media platform in Canada and presents an opportunity to recruit vaccine-hesitant parents in a novel manner. OBJECTIVE: The study aimed to explore the use of Facebook as a tool to reach vaccine-hesitant parents, as compared with RDD methods. …”
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    Facebook Recruitment of Vaccine-Hesitant Canadian Parents: Cross-Sectional Study
  3. 102383
    “…Randomization was done in a stratified manner according to symptom severity, resulting in two subgroups of patients: severe and moderate. …”
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    A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial
  4. 102384
    “…Finally sIL-6R/IL-6 limited IL-27-effects, particularly in NCI-H69 cells, in a SOCS3-independent manner, but did not modify IFN-γ induced HLA class I up-regulation. …”
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    IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells
  5. 102385
    “…The EOs also scavenged three other different radicals (2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical, lipid peroxyl radical, and nitric oxide radical) in concentration-dependent manner. CONCLUSION: Our results suggest that apart from the indigenous uses of the plant extracts, the EO contains strong bioactive compounds with antibacterial and radicals scavenging properties and may be good alternative candidates in the search for novel potent antibiotics in this present era of increasing multidrug-resistant bacterial strains as well as effective antioxidants agents. …”
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    Bioactive Constituents, Radical Scavenging, and Antibacterial Properties of the Leaves and Stem Essential Oils from Peperomia pellucida (L.) Kunth
  6. 102386
    “…In this phase 3 study, 460 patients were randomised in a double-blind manner to either lenalidomide (n=231) or placebo (n=229) utilizing a permutated-block randomisation with fixed block size. …”
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    Updated analysis of CALGB 100104 (Alliance): a randomised phase III study evaluating lenalidomide vs placebo maintenance after single autologous stem cell transplant for multiple myeloma
  7. 102387
    “…Volume in a voxelwise manner. FEP and controls were matched for age, sex and parental socioeconomic status. …”
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    T165. ULTRA-HIGH FIELD MORPHOMETRY IN DRUG-NAïVE FIRST EPISODE PSYCHOSIS
  8. 102388
    por Kott, Alan, Daniel, David
    Publicado 2018
    “…We plan to further explore the potential utility of equations addressing the relationships among schizophrenia measures of symptom severity in an iterative manner with larger datasets.…”
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    T56. AN EXPLORATORY ANALYSIS CONVERTING SCORES BETWEEN THE PANSS AND BNSS
  9. 102389
    “…However, no studies have elucidated if ω-3 PUFA affects the HMGB1/NF-κB pathway in a HMGB1 deacetylation of dependent SIRT1 manner, thus regulating microglial polarization and the subsequent neuroinflammatory response. …”
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    Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury
  10. 102390
    “…Participants were randomized to receive normative feedback that compared their scores to a reference group or humor-driven feedback that presented their scores in a relaxed manner. Those who scored in the moderate or poor ranges in any measure were encouraged to seek help by clicking on a link to an external online resource. …”
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    Impact of Mental Health Screening on Promoting Immediate Online Help-Seeking: Randomized Trial Comparing Normative Versus Humor-Driven Feedback
  11. 102391
    Publicado 2015
    “…NF-κB luciferase activity of SPC-A-1 cells was the highest, and the activity was increased in a dose-dependent manner. 0.1 μg/mL flagellin could significantly increase the NF-κB luciferase activity (P < 0.05), while its activity could be inhibited by the TLR5 antibody in a negative correlation. …”
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    TLR5在不同非小细胞肺癌细胞株的表达及其活化机制的初步探讨
  12. 102392
    “…The aim of this study was to analyze the individual time-delayed linear effect relationship between training load and recovery-stress state with single case time series methods and to monitor the acute recovery-stress state of high-performance swimmers in an economical and multidimensional manner over a macro cycle. The Acute Recovery and Stress Scale (ARSS) was used for daily monitoring of the recovery-stress state. …”
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    Relation Between Training Load and Recovery-Stress State in High-Performance Swimming
  13. 102393
    “…Moreover, in human lung tumor tissues, the expression of Chi3L1 was increased but USF1 was decreased in a stage-dependent manner. Finally, Chi3L1 expression was strongly regulated by the indirect translational suppressing activity of USF1 through induction of miR-125a-3p, a target of Chi3L1. …”
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    Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1
  14. 102394
    “…Our results suggested that stocking density did affect milk oxidation capacity but in a physiological-stage dependent manner. Nutritional strategies should be developed to improve the milk oxidation capacity of cows managed under a low stocking density. …”
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    Effects of Stocking Density on Milk Fatty Acids Composition and Oxidative Stability of Mid- and Late-Lactating Dairy Cows
  15. 102395
    “…Plasma exposure to CBD [maximum plasma concentration (C(max)) and area under the plasma concentration-time curve from time zero to time t (AUC(t))] increased in a less than dose-proportional manner (C(max) slope 0.73; AUC(t) slope 0.64). Oral clearance of CBD was high (1111–1909 L/h) and apparent volume of distribution was large (20,963–42,849 L). …”
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    A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
  16. 102396
    “…HB-101-induced gB-specific IgG antibody responses at all doses, in a dose-dependent manner. All three dose levels also induced antibodies that neutralized HCMV infection in cultured human fibroblasts (MRC-5 cells), and resulted in a robust, boosterable and durable T-cell response by IFNγ ELISPOT for CMV gB and pp65. …”
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    1531. A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 Is Safe and Immunogenic in Healthy Volunteers, Allowing for Development of a Phase II Clinical Trial in Living Donor Kidney Transplant Recipients
  17. 102397
    “…RESULTS: BXA was detected in ferret plasma after a single oral administration of BXM at 10 and 30 mg/kg, in more than a dose-proportional manner. When the treatment was initiated at 1 day p.i., BXM at 10 and 30 mg/kg showed reduction of virus titer to an undetectable level on day 2 p.i. and statistically significant reduction in virus titer over time from day 2 to 3 p.i. compared with vehicle and oseltamivir phosphate. …”
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    1350. Therapeutic Effects of Baloxavir Marboxil against Influenza A Virus Infection in Ferrets
  18. 102398
    “…We found that lnc-UCA1 acted as miR-627-5p sponge in a sequence-specific manner. Meanwhile, upregulated lnc-UCA1 inhibited miR-627-5p expression. …”
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    NR2C2-uORF targeting UCA1-miR-627-5p-NR2C2 feedback loop to regulate the malignant behaviors of glioma cells
  19. 102399
    “…Using the linear regression equation of the relationship between PRRD1 and PCT previously generated in half of the DHP-treated children during the early study phase, PCT estimates were compared in a prospective blinded manner with PCTs determined by microscopy during the later study phase in the remaining half. …”
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    Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children
  20. 102400
    “…Class III (i.e., NP88, NP110) expressed CITED1, ADIPOQ, C19orf80, and UCP1 in a similar manner as fetal BAT-derived (fBAT) cells. Differentiated NP88 and NP110 lines were closest to fBAT cells morphologically in adiponectin and uncoupling protein expression. …”
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    Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
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