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  1. 102461
    “…Taken together, our results suggest that the CAD/SOAR apex is in the immediate vicinity of the ER membrane in the STIM1 quiescent state and that different mutations therein can impact the STIM1/Orai1 activation cascade in various manners. GRAPHIC ABSTRACT: [Image: see text] Legend: Upon intracellular Ca(2+) store depletion of the endoplasmic reticulum (ER), Ca(2+) dissociates from STIM1. …”
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    Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade
  2. 102462
    “…CONCLUSION: In summary, our results demonstrated that TGF-ΒR2 AG and AA genotypes were associated with a reduced risk of CRC, as well as circulating levels of TGF-β could prevent CRC development in a gender-specific manner. Notably, male carriers of TGF-ΒR2 -875A allele genotypes had a lower risk of CRC development and progression, suggesting that TGF-ΒR2 -875A/G polymorphism significantly affects the protective biological factors that also impact the risk of colon and rectal carcinogenesis.…”
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    Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men
  3. 102463
    “…Furthermore, treatment with 0.25 and 0.5 mM of oxalate for 48 h significantly upregulated NEAT1, PVT1, CCL7, and ROBO2 expression levels and downregulated hsa-miR-23b-3p, hsa-miR-429, and hsa-miR-139-5p expression levels in the HK-2 cell line in a dose-dependent manner. Conclusion: We found that significant expressions of ceRNAs (NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR-139-5p, CCL7, and ROBO2) and infiltrating immune cells (macrophages and mast cells) may be involved in kidney stone pathogenesis. …”
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    Construction and Analysis of Immune Infiltration-Related ceRNA Network for Kidney Stones
  4. 102464
    “…SLIT3 LRRD2 dissociated M‐cadherin‐bound β‐catenin and up‐regulated myogenin expression to increase myoblast differentiation, in a manner similar to full‐length SLIT3. Systemic treatment with SLIT3 LRRD2 increased skeletal muscle mass in both ovariectomized and aged mice (all, P < 0.05). …”
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    SLIT3 promotes myogenic differentiation as a novel therapeutic factor against muscle loss
  5. 102465
    “…Mothers who begin attending ANC in a timely manner, can fully benefit from preventive and curative services. …”
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    Timely initiation of antenatal care and its associated factors among pregnant women in sub-Saharan Africa: A multicountry analysis of Demographic and Health Surveys
  6. 102466
    “…At present, PI-QUAL offers clinicians the only available tool for evaluating and reporting the quality of prostate mpMRI in a systematic manner but further refinements of this scoring system are warranted. …”
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    Inter-reader agreement of the PI-QUAL score for prostate MRI quality in the NeuroSAFE PROOF trial
  7. 102467
    “…This can be complemented by the development of AuNPs synthesized in an environmentally friendly manner AuNPs using natural plant extracts for the treatment of antibiotic-resistant microorganisms.…”
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    Therapeutic effect of biosynthetic gold nanoparticles on multidrug-resistant Escherichia coli and Salmonella species isolated from ruminants
  8. 102468
    “…RESULTS: The plasma levels of PMB were found to increase in dose-dependent manner in both the groups. At 3 and 9 mg/kg/day, the plasma PMB exposure were similar for both VRP-034 and marketed PMB groups (AUC(0–24): 6.47 ± 0.41 μg/mL·h versus 5.66 ± 0.24 μg/mL·h, P>0.05 and 22.90 ± 1.96 μg/mL·h versus 26.84 ± 1.43 μg/mL·h, P>0.05). …”
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    P07 Toxicokinetic profile of VRP-034
  9. 102469
    “…BACKGROUND: At the 7th Electropalatography Symposium in Japan, held online on the 24 January 2021, a few speakers were invited to talk about how the COVID‐19 pandemic had impacted their research and/or speech therapy that involved the use of electropalatography (EPG) as well as the procedures adopted in order to continue their work in a safe manner. The information on protective measures when using instrumental techniques in speech research and therapy may be useful for colleagues in research and the clinic. …”
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    Electropalatography (EPG) activities in Japan and the impact of the COVID‐19 pandemic on EPG research and therapy: A report of presentations at the 7th EPG Symposium
  10. 102470
    “…Persisting black holes (PBHs) were defined as a subset of T2 lesions with a signal below a patient-specific grey matter T1 intensity in a semi-quantitative manner. SELs, PBH counts, and brain volume were computed, and their associations were assessed through Spearman and Pearson correlation. …”
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    Slowly expanding lesions relate to persisting black-holes and clinical outcomes in relapse-onset multiple sclerosis
  11. 102471
    “…According to the trend test, the prevalence of miscarriage was increased in a titer-dependent manner with the raised levels of serum anti-ENO1-P6 total IgG and IgG1, IgG2, and IgG3 subtypes among euthyroid TAI females. …”
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    A Predictive Role of Autoantibodies Against the Epitope aa168–183 of ENO1 in the Occurrence of Miscarriage Related to Thyroid Autoimmunity
  12. 102472
    “…In addition, the supporting effect of prehabilitation on postoperative regeneration and QoL should be highlighted, illustrating prolonged beneficial effects of BFR on muscular and functional performance in a “better in, better out”-manner.…”
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    Impact of a Six-Week Prehabilitation With Blood-Flow Restriction Training on Pre- and Postoperative Skeletal Muscle Mass and Strength in Patients Receiving Primary Total Knee Arthroplasty
  13. 102473
    “…The combination therapy promoted M1-like macrophages and activated antigen-presenting cells while decreasing M2-like macrophages and regulatory T cells in a tumor-dependent manner. This was associated with increased levels of IFN-γ, IL-12, chemokine (C-X-C motif) ligand 9 (CXCL9), and CXCL13 in the TME. …”
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    Tumor-targeted interleukin-12 synergizes with entinostat to overcome PD-1/PD-L1 blockade-resistant tumors harboring MHC-I and APM deficiencies
  14. 102474
    “…Demand for these procedures is rapidly increasing and thus there is a need to perform them in an efficient manner. However, there are little data comparing the efficiency of pediatric endoscopic procedures in diverse clinical environments. …”
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    Pediatric endoscopy across multiple clinical settings: Efficiency and adverse events
  15. 102475
    “…Image artifacts, including hair, pen markings, ulceration, and imaging source institution, decreased accuracy in a complex manner that varied based on the underlying diagnosis. …”
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    Validation of artificial intelligence prediction models for skin cancer diagnosis using dermoscopy images: the 2019 International Skin Imaging Collaboration Grand Challenge
  16. 102476
    “…Analyses were done in an intention-to-treat manner. This trial is ongoing and is registered at ClinicalTrials.gov, NCT02754583. …”
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    Water, sanitation, and hygiene for control of trachoma in Ethiopia (WUHA): a two-arm, parallel-group, cluster-randomised trial
  17. 102477
    “…Independent validation was performed with targeted sequencing of 259 urine samples in a double‐blinded manner to determine the clinical diagnosis and prognosis value of DNAm‐based classification models. …”
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    Non‐invasive diagnosis and surveillance of bladder cancer with driver and passenger DNA methylation in a prospective cohort study
  18. 102478
    “…Additionally, the operation is simple and solvent free, the entire analytical procedure was executed in a “green” manner. A PM2.5 filter was analyzed, and 26 different polar compounds were successfully derived, including monoacids, binary acids, aromatic acids, and alcohols, covering most of the common target polar compounds in atmospheric chemical analysis. …”
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    大气颗粒物滤膜中极性有机物在线衍生装置的设计与应用
  19. 102479
    “…Previous ChIP and expression studies of individual genes suggested that p53 sites in HERV LTRs may be part of the p53 transcription program and directly regulate p53 target genes in a species-specific manner. However, the exact function of p53 in the regulation of HERV LTR expression is largely elusive. …”
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    p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity
  20. 102480
    “…The sessions included a reading session with AI and a session without AI, in a randomized crossover manner with a 4-week washout period in between. The AI produced a heat map and the image-level probability of the presence of the referrable lesion. …”
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    Association of Artificial Intelligence–Aided Chest Radiograph Interpretation With Reader Performance and Efficiency
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