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  1. 102521
    “…The western blot results also indicated that rTsCatL2 increased the expression levels of phospho-NF-κB and phospho-nuclear factor-κB inhibitor alpha (IκB-α) proteins in a dose-dependent manner, while immunofluorescence revealed that rTsCatL2 induced nuclear translocation of the p65 subunit of NF-κB (NF-κB p65) protein in macrophages. …”
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    Trichinella spiralis cathepsin L induces macrophage M1 polarization via the NF-κB pathway and enhances the ADCC killing of newborn larvae
  2. 102522
    por Jankowski, Janusz A Z, de Caestecker, John, Love, Sharon B, Reilly, Gavin, Watson, Peter, Sanders, Scott, Ang, Yeng, Morris, Danielle, Bhandari, Pradeep, Attwood, Stephen, Ragunath, Krish, Rameh, Bashir, Fullarton, Grant, Tucker, Art, Penman, Ian, Rodgers, Colin, Neale, James, Brooks, Claire, Wise, Adelyn, Jones, Stephen, Church, Nicholas, Gibbons, Michael, Johnston, David, Vaidya, Kishor, Anderson, Mark, Balata, Sherzad, Davies, Gareth, Dickey, William, Goddard, Andrew, Edwards, Cathryn, Gore, Stephen, Haigh, Chris, Harding, Timothy, Isaacs, Peter, Jackson, Lucina, Lee, Thomas, Lim, Peik Loon, Macdonald, Christopher, Mairs, Philip, McLoughlin, James, Monk, David, Murdock, Andrew, Murray, Iain, Preston, Sean, Pugh, Stirling, Smart, Howard, Soliman, Ashraf, Todd, John, Turner, Graham, Worthingon, Joy, Harrison, Rebecca, Barr, Hugh, Moayyedi, Paul
    Publicado 2018
    “…Patients with Barrett's oesophagus of 1 cm or more were randomised 1:1:1:1 using a computer-generated schedule held in a central trials unit to receive high-dose (40 mg twice-daily) or low-dose (20 mg once-daily) PPI, with or without aspirin (300 mg per day in the UK, 325 mg per day in Canada) for at least 8 years, in an unblinded manner. Reporting pathologists were masked to treatment allocation. …”
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    Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial
  3. 102523
    “…The results identified a number of themes for improving MOC in each domain, which included: the importance of patients receiving communication that is of a higher quality and in different formats on their fertility risk and FP options; improving provision of oncofertility care in a timely manner; improving access to age-appropriate care; defining the role and scope of practice of all HCPs; and improving communication between different HCPs. …”
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    How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care
  4. 102524
    “…The production phase behaved in a similar manner, where glucose addition of [Formula: see text] resulted in fumarate production of [Formula: see text] and a yield of [Formula: see text] fumarate on glucose. …”
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    Fumarate production with Rhizopus oryzae: utilising the Crabtree effect to minimise ethanol by-product formation
  5. 102525
    “…RESULTS: The mean observed BC 007 area under the concentration–time curve (AUC(0–24)) increased with increasing dose in a dose proportional manner (slope estimate of 1.039). No serious adverse events were observed. …”
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    A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein Coupled Receptors in Healthy, Young and Elderly Subjects
  6. 102526
    “…Finally, 47% of the respondents believed that the accumulated workload could be dealt with in a timely manner after the COVID-19 outbreak, but 50% thought the postponement of urological services would affect the treatment and survival outcomes of their patients. …”
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    A Global Survey on the Impact of COVID-19 on Urological Services
  7. 102527
    “…Peak and total plasma exposure to TRV250 increased in a dose-proportional manner following 0.1–30 mg SC doses, with the mean half-life ranging from 2.39 to 3.76 h. …”
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    A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-Selective Delta Receptor Agonist, in Healthy Subjects
  8. 102528
    “…RESULTS: Larval densities at the landscape scale varied seasonally in a similar manner over the entire simulation period, regardless of WTD habitat use preferences. …”
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    Effects of white-tailed deer habitat use preferences on southern cattle fever tick eradication: simulating impact on “pasture vacation” strategies
  9. 102529
    “…The final analysis would be conducted in a blinded manner as per the statistical analysis plan (SAP) to estimate the primary outcomes of sepsis, possible serious bacterial infection (PSBI), and secondary outcomes. …”
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    Evaluating the efficacy of a multistrain probiotic supplementation for prevention of neonatal sepsis in 0–2-month-old low birth weight infants in India—the “ProSPoNS” Study protocol for a phase III, multicentric, randomized, double-blind, placebo-controlled trial
  10. 102530
    “…RESULTS: Factors interacting with PIK3CA mutations in a higher-order manner significantly influenced patient cohort survival curves (hazard ratio (HR) = 2.93, p-value = 2.63 × 10(− 6)). …”
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    Identification of PIK3CA multigene mutation patterns associated with superior prognosis in stomach cancer
  11. 102531
    “…However, PLC-γ1 could also be activated in a PTK-independent manner by phospholipase D (PLD)-derived phosphatidic acid (PA). …”
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    The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells
  12. 102532
    “…We reported a positive independent association between 25OHD and handgrip strength in a population of 130 hemodialysis patients in a dose-dependent manner. In our cohort, a plateau effect was observed above 75 nmol/L. …”
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    VITADIAL “Does correction of 25 OH-VITAmin D with cholecalciferol supplementation increase muscle strength in hemoDIALysis patients?”: study protocol for a randomized controlled trial
  13. 102533
    “…Multivariate logistic regression models were conducted in a forward manner to exclude the influence of confounding factors. …”
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    Efficacy of three COS protocols and predictability of AMH and AFC in women with discordant ovarian reserve markers: a retrospective study on 19,239 patients
  14. 102534
    “…Data from 15 centers were collected on a web-based platform and managed in a de-identified manner. We performed a subgroup analysis of pts with LPD and COVID-19. …”
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    ABCL-274: Outcomes in Patients with Lymphoproliferative Diseases and COVID-19: Results of a Subgroup Analysis of the CHRONOS19 Registry
  15. 102535
    “…Our group and others have reported early and dramatic losses of brain sulfatide in AD cases and animal models that are mediated by ApoE in an isoform-dependent manner and accelerated by Aβ accumulation. To date, it remains unclear if changes in specific brain lipids are sufficient to drive AD-related pathology. …”
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    Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment
  16. 102536
    “…RESULTS: When MitoTracker Deep Red-labeled high-metastatic Lewis lung carcinoma A11 cells carrying the ND6 G13997A mtDNA mutation were cocultured with CellLight mitochondria-GFP-labeled low-metastatic P29 cells harboring wild-type mtDNA, bidirectional transfer of red- and green-colored vesicles, probably mitochondria-related EVs, was observed in a time-dependent manner. Similarly, intercellular transfer of mitochondria-related EVs occurred between A11 cells and α-smooth muscle actin (α-SMA)-positive cancer-associated fibroblasts (CAFs, WA-mFib), macrophages (RAW264.7) and cytotoxic T cells (CTLL-2). …”
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    Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles
  17. 102537
    “…BACKGROUND: Bovine milk contains extracellular vesicles (EVs) that play a role in cellular communication, acting in either an autocrine, paracrine, or an exocrine manner. The unique properties of the EVs protect the cargo against degradation. …”
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    Non-coding RNA in raw and commercially processed milk and putative targets related to growth and immune-response
  18. 102538
    “…BMMSCs are a target of vitamin D action, and the metabolism of 25(OH)D(3) to biologically active 1α,25(OH)(2)D(3) in BMMSCs promotes osteoblastogenesis in an autocrine/paracrine manner. Our previous study with human BMMSCs showed that megalin is required for the 25(OH)D(3)-DBP complex to enter cells and for 25(OH)D(3) to stimulate osteoblast differentiation in BMMSCs. …”
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    Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D(3) is mediated by inhibition of chaperone-mediated autophagy
  19. 102539
    “…Plasma exposures for area under the plasma concentration–time curve up to 12 h (AUC(0–12)) and mean maximum concentrations (C(max)) increased in a slightly greater-than-dose-proportional manner across the dose range studied. Interindividual pharmacokinetic variability was low to moderate, with a percent coefficient of variation of < 32% for AUC and < 43% for C(max). …”
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    Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection
  20. 102540
    “…Que induced apoptosis of MCF-10AT, MCF-7 and MDA-MB-231 cells in a time- and concentration-dependent manner (P < 0.05). Most importantly, Que promoted the differentiation of γδ T cells into the Vδ2 T cell subpopulation. …”
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    To explore immune synergistic function of Quercetin in inhibiting breast cancer cells
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