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  1. 102621
    “…Conclusion: Treatment of acromegaly leads to an increase in AT mass in a depot and sex specific manner both at short-term and long-term follow-up. …”
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    THU067 Long-term Depot Specific Changes In Adipose Tissue After Treatment Of Acromegaly
  2. 102622
    “…In previous studies, AZP-3813 was demonstrated to suppress IGF1 secretion in juvenile rats in a dose-related manner, and to maintain IGF1 suppression when given daily for extended periods. …”
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    THU046 Repeated Treatment With AZP-3813, A Bicyclic, 16-Amino Acid Peptide Antagonist Of The Human Growth Hormone Receptor, Induces Enhanced Suppression Of IGF1 In Beagle Dogs
  3. 102623
    “…While the mechanisms by which MKRN3 regulates puberty onset have been partially elucidated in recent years, the manner by which DLK1 regulates HPG axis maturation remains unknown. …”
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    OR04-06 Mkrn3, Dlk1 And Mecp2 Have Distinct Hypothalamic Expression Patterns Across Pubertal Maturation In Male And Female Mice
  4. 102624
    “…These data suggested that Esr1 might be protective- and Ar detrimental- for beta cell function, but not in a sex-dependent manner. Collectively, these data demonstrate a sexual dimorphism in islet response to inflammation, with evidence of a more aggressive inflammatory response in males. …”
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    FRI613 Sex Differences In Human Islet Transcriptional Responses To Inflammation
  5. 102625
    “…Thus changes in creatinine-derived eGFR during hormone therapy may not reflect true changes in GFR. Another manner to estimate GFR, which is not affected by body composition, is by measuring plasma cystatin C concentrations. …”
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    OR31-06 Gender-Affirming Hormone Therapy Affects Serum Cystatin C-based eGFR In Transgender Individuals
  6. 102626
    “…We have previously shown that PA is frequently regulated by aberrant stimuli, including the upright posture stimulation test (UPT), in which plasma aldosterone concentrations (PAC) increase in a renin-independent manner. In this study, we further examined the usefulness of UPT in diagnosing PA. …”
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    FRI130 Usefulness Of The Upright Posture Test In The Diagnosis Of Primary Aldosteronism
  7. 102627
    “…In line with this, HM15136 promoted glycogenolysis and gluconeogenesis in rat primary hepatocytes in a dose dependent manner (relative potency = ca.20%), confirming glucose producing nature of HM15136. …”
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    SAT149 In Vitro Characterization Of A Novel Long-acting Glucagon Analog (HM15136) And Its Potential Effect In Animal Models Of Chronic Hypoglycemic Diseases
  8. 102628
    “…Parathyroid oxyphil cells are comparable to chief cells at the transcriptional level, and vitamin D-status is reflected in the transcriptional profiles of both cell types in a similar manner. Among PHPT patients who did not present as vitamin D deficient, three distinct tumor transcriptional profile clusters showed a dose-dependent relationship to pre-operative 25OHD levels (p <0.0001 by ANOVA). …”
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    THU396 Digital Spatial Profiling Of Human Parathyroid Tumors Reveals Distinct Cellular And Molecular Alterations Linked To Vitamin D Deficiency
  9. 102629
    Publicado 2015
    “…They operated their own hospitals or clinics in a manner similar to the mission hospitals by providing treatment for poor patients free of charge or for a nominal fee and treating the patients in a kind and humanistic way. …”
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    일제 하 캐나다 장로회의 선교의료와 조선인 의사: 성진과 함흥을 중심으로
  10. 102630
    “…Commercially available mobile mindfulness apps can deliver MBIs to caregivers of persons with ADRD in a feasible and cost-effective manner. OBJECTIVE: We are conducting a single-blind feasibility proof-of-concept randomized controlled trial (RCT; National Institutes of Health [NIH] stage 1B) comparing 2 free mobile apps: the active intervention Healthy Minds Program (HMP) with within-app text tailored for addressing stress among caregivers of persons with ADRD, versus Wellness App (WA), a time- and dose-matched educational control also tailored for caregivers of persons with ADRD. …”
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    Mindfulness-Based App to Reduce Stress in Caregivers of Persons With Alzheimer Disease and Related Dementias: Protocol for a Single-Blind Feasibility Proof-of-Concept Randomized Controlled Trial
  11. 102631
    “…To help with the complexity of deciding whether a patient needs IMV, machine learning algorithms may help bring more prognostic value in a timely and systematic manner. Chest radiographs (CXRs) and electronic medical records (EMRs), typically obtained early in patients admitted with COVID-19, are the keys to deciding whether they need IMV. …”
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    A Hybrid Decision Tree and Deep Learning Approach Combining Medical Imaging and Electronic Medical Records to Predict Intubation Among Hospitalized Patients With COVID-19: Algorithm Development and Validation
  12. 102632
    “…In vitro experiments showed that the extracts of P. polyphylla var. yunnanensis from three origins could inhibit the proliferation and induce cell apoptosis of 4T1 cells in a concentration- and time-dependent manner, especially in the C1 origin. In vivo experiments showed that the extract of P. polyphylla var. yunnanensis from the three origins could inhibit the growth of tumors and induce the apoptosis of tumor cells. …”
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    Analysis of the heavy metal contents’ effect on steroidal saponins and the anti-breast cancer activity of Paris polyphylla var. yunnanensis
  13. 102633
    “…Among Black individuals, the risk of PPD was the greatest overall and increased with neighborhood disadvantage in a dose-response manner (quartile [Q] 2 ARR, 1.39 [95% CI, 1.13-1.71]; Q3 ARR, 1.50 [95% CI, 1.23-1.83]; Q4 ARR, 1.60 [95% CI, 1.32-1.93]; Cochrane-Armitage test for trend, P < .001). …”
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    Neighborhood Disadvantage, Race and Ethnicity, and Postpartum Depression
  14. 102634
    “…ABSTRACT: Circular RNAs (circRNAs) are a class of novel non-coding RNAs (ncRNAs) that play essential roles in the development and growth of vertebrates through multiple manners. However, the mechanism by which circRNAs modulate the honey bee gut development is currently poorly understood. …”
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    Novel Insights into the circRNA-Modulated Developmental Mechanism of Western Honey Bee Larval Guts
  15. 102635
    “…There were significant differences in cyst diameter grouping strains in the following manner according to this parameter: 1) San Francisco Bay (SFB-Control, USA), 2) Galerazamba and Tayrona, 3) Kangarú, 4) Manaure, and 5) Salina Cero and Pozos Colorados. …”
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    Determination of biological and physicochemical parameters of Artemia franciscana strains in hypersaline environments for aquaculture in the Colombian Caribbean
  16. 102636
    “…Relevant ethical procedures associated with the collection of interview data were adopted: interviews were conducted in a non-coercive manner and confidentiality was assured. All participants provided verbal consent, and agreed to be interviewed without financial or other incentive. …”
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    Response of religious groups to HIV/AIDS as a sexually transmitted infection in Trinidad
  17. 102637
    por Buerger, Leo
    Publicado 1905
    “…The chief cultural tests are the following: the manner of growth upon the serum-glucose-agar, and the modified inulin-serum water, and the appearance of the "ring-type" of colony. 19. …”
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    STUDIES OF THE PNEUMOCOCCUS AND ALLIED ORGANISMS WITH REFERENCE TO THEIR OCCURRENCE IN THE HUMAN MOUTH
  18. 102638
    “…The beating rate and survival of NeRCaMs decreased in a concentration and time-dependent manner after doxorubicin treatment (P<0.0005). This cytotoxicity was associated with an increase in the LDH release from the treated cells (P<0.0005). …”
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    A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro
  19. 102639
    por Brand, Richard A.
    Publicado 2008
    “…He commented, “Several members of the Osteomyelitis Service did not look with favor upon this method of treatment, and the orthopaedic surgeon responsible for the treatment did not feel any too confident; consequently, the cases treated in this manner were few and far between, and progress was proportionally slow” [7]. …”
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    Local Chemotherapy with Primary Closure of Septic Wounds by Means of Drainage and Irrigation Cannulae: M. N. Smith-Petersen MD (1886–1953), Carroll B. Larson MD, Williams Cochran MD The 12th President of the AAOS 1943 (MNS-P)
  20. 102640
    “…In addition, transport is inhibited by the uricosuric benzbromarone in a dose-dependent manner (K (i) = 27 μM). Furthermore, we found urate uptake was at least 2-fold greater in human embryonic kidney (HEK) cells overexpressing SLC2A9 splice variants than nontransfected kidney cells. …”
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    SLC2A9 Is a High-Capacity Urate Transporter in Humans
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