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  1. 102681
    “…BACKGROUND: Cellular mobile telephone technology shows much promise for delivering and evaluating healthcare interventions in cost-effective manners with minimal barriers to access. There is little data demonstrating that these devices can accurately measure clinically important aspects of individual functional status in naturalistic environments outside of the laboratory. …”
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    Mobile Phone-Based Measures of Activity, Step Count, and Gait Speed: Results From a Study of Older Ambulatory Adults in a Naturalistic Setting
  2. 102682
    “…RESULTS: Sequential-stress-treated rats simultaneously demonstrated anxiety-like behaviors and GHS in dose-dependent manner compared with the control group. Although rats in both groups consumed similar amount of solid food, the rate of gastric emptying was lower in the sequential-stress-treated rats than in the control group. …”
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    Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress
  3. 102683
    “…Moreover, a detailed parametric analysis clarifies the effects of the particles size and density in terms of regional deposition upon several parts of the pulmonary system. In this manner, the deposition pattern of various substances can be assessed. …”
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    Substance deposition assessment in obstructed pulmonary system through numerical characterization of airflow and inhaled particles attributes
  4. 102684
    “…Viwithan induced late apoptotic changes in treated B16F1 cells as evident by the ladder formation of fragmented DNA in a time-dependent manner. The findings of molecular docking showed that withanolides present in Viwithan have a more binding affinity with the antiapoptotic proteins, particularly MCL-1. …”
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    Viwithan, a Standardized Withania somnifera Root Extract Induces Apoptosis in Murine Melanoma Cells
  5. 102685
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    Formal description of sequence-based voucherless Fungi: promises and pitfalls, and how to resolve them
  6. 102686
    “…CONCLUSIONS: The proposed categories are suited for an unequivocal assessment of AEs even in a retrospective manner and useful for benchmarking. AE rates in the present cohorts from our institution compare favorable with the literature.…”
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    Towards unambiguous reporting of complications related to deep brain stimulation surgery: A retrospective single-center analysis and systematic review of the literature
  7. 102687
    “…If patients are accurate and engaged self-reporters, collecting this information in a manner that is temporally proximate to the health care utilization events themselves may prove valuable to health care organizations undertaking quality improvement initiatives for which such data are often unavailable. …”
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    Accuracy of Internet-Based Patient Self-Report of Postdischarge Health Care Utilization and Complications Following Orthopedic Procedures: Observational Cohort Study
  8. 102688
    “…RESULTS: STAT3 siRNA inhibited the growth of KCs in a time-dependent manner showing the highest proliferation inhibition in LUS group with proliferation ratio of 45.38% ± 5.85% at 72h (P < 0.05 vs. …”
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    Effect of RNA Interference Targeting STAT3 Gene Combined with Ultrasonic Irradiation and SonoVue Microbubbles on Proliferation and Apoptosis in Keratinocytes of Psoriatic Lesions
  9. 102689
    “…RESULTS: Exposure to high fructose increased triglyceride levels in a dose- and time-dependent manner and significantly increased mRNA levels of SREBP-1c and ChREBP and protein levels of FAS, ACC, and SCD-1, concomitant with XBP-1 conversion to an active spliced form. …”
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    Role of X-Box Binding Protein-1 in Fructose-Induced De Novo Lipogenesis in HepG2 Cells
  10. 102690
    “…This experience motivated the development of a less formal method of sharing complex information and ideas in a simplified manner. “Meet the Researchers” aims to make researchers accessible to patients in order to raise awareness and understanding of research and to explain how research translates into, and informs practice. …”
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    Meet the researchers: an alternative method of engaging patients with research in mesothelioma
  11. 102691
    “…WIDER IMPLICATIONS OF THE FINDINGS: Our results suggest that the rs10732516 polymorphism associates with the alcohol-induced alterations in DNA methylation profiles and head growth in a parent-of-origin manner. We also introduce a novel genotype-specific approach for exploring environmental effects on the IGF2/H19 locus and ultimately on embryonic growth. …”
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    rs10732516 polymorphism at the IGF2/H19 locus associates with a genotype-specific trend in placental DNA methylation and head circumference of prenatally alcohol-exposed newborns
  12. 102692
    “…MAIN RESULTS AND THE ROLE OF CHANCE: In the offspring’s COC, maternal obesity increased both growth differentiation factor 9 (Gdf9: 2-fold; P < 0.05, HFD versus chow) and bone morphogenetic protein 15 (Bmp15: 4-fold; P < 0.05, HFD versus chow) mRNA expression levels while exercise and NMN interventions did not regulate Gdf9 and Bmp15 in the same manner. In whole ovary, maternal diet programmed a 25–50% reduction in FSH receptor and sirtuin-3 mRNA expression levels in daughter ovaries (P < 0.05, HFD versus chow). …”
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    Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide
  13. 102693
    “…METHODS: Following University Ethics approval, twenty-seven healthy, male rowers (age: 24 ± 2 years; body-height: 1.81 ± 0.02 m; body-mass: 82.3 ± 2.5 kg; body-fat: 14.2 ± 1.0%) were randomised in a double-blind manner to 4 weeks of: i) βA (2.4 g·d(− 1), βA1); ii) matched total βA (4.8 g on alternate days, βA2); or iii) cornflour placebo (2.4 g·d(− 1), PL). …”
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    The effect of two β-alanine dosing strategies on 30-minute rowing performance: a randomized, controlled trial
  14. 102694
    “…Results: LPS affects hCMEC/D3 TJ permeability in a concentration- and time-dependent manner. LPS intervention resulted in a significant disruption of BBB, as manifested by decreased TEER (by ~26%) and a parallel increased paracellular permeability to FITC- (4kDa) dextrans through hCMEC/D3 monolayers. …”
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    Omi/HtrA2 Protease Associated Cell Apoptosis Participates in Blood-Brain Barrier Dysfunction
  15. 102695
    “…In terms of behavior, physiotherapists delivered SOLAS in a needs supportive manner (HCCQ: median 5.2, interquartile range 1.3, min-max 3.7-5.8; CCBS: median 6.6, interquartile range 1.0, min-max 5.6-7.0; ISM: median 4.5, interquartile range 1.2, min-max 2.8-4.8). …”
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    Evaluation of an E-Learning Training Program to Support Implementation of a Group-Based, Theory-Driven, Self-Management Intervention For Osteoarthritis and Low-Back Pain: Pre-Post Study
  16. 102696
    “…This post-hoc analysis showed that greater weight loss was associated with greater improvements in 6MWD in a linear manner, indicating gains in walking capacity. Supported by Novo Nordisk.…”
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    MON-120 Effect of Weight Loss on Physical Function Measured by the 6-Minute Walking Distance Test in Individuals with Obesity: Results from the SCALE IBT Trial of Liraglutide 3.0 Mg
  17. 102697
    “…Inhibition of A1CF significantly restrained cell proliferation, migration and invasion, and promoted apoptosis by upregulating miR-590-3p in a FAM224A-dependent manner. FAM224A was a molecular sponge of miR-590-3p and they were in an RNA-induced silencing complex. …”
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    Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells
  18. 102698
    “…Notably, reactivation of AMPK, in a PIKFYVE-dependent manner, or of MCOLN1 in RC-deficient cells, restores lysosomal hydrolytic capacity. …”
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    Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis
  19. 102699
    “…RESULTS: L48H37 inhibited the proliferation and induced apoptosis in SW1990 and ASPC-1 cells in a dose- and time-dependent manner, while also reducing MMP, increasing ROS levels, arresting cell cycle at the G2/M stages and activating the endoplasmic reticulum (ER) stress-associated protein kinase RNA-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 (ATF4)/CHOP signaling pathway. …”
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    KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma
  20. 102700
    por Aibana, Omowunmi, Huang, Chuan-Chin, Aboud, Said, Arnedo-Pena, Alberto, Becerra, Mercedes C., Bellido-Blasco, Juan Bautista, Bhosale, Ramesh, Calderon, Roger, Chiang, Silvia, Contreras, Carmen, Davaasambuu, Ganmaa, Fawzi, Wafaie W., Franke, Molly F., Galea, Jerome T., Garcia-Ferrer, Daniel, Gil-Fortuño, Maria, Gomila-Sard, Barbará, Gupta, Amita, Gupte, Nikhil, Hussain, Rabia, Iborra-Millet, Jesus, Iqbal, Najeeha T., Juan-Cerdán, Jose Vicente, Kinikar, Aarti, Lecca, Leonid, Mave, Vidya, Meseguer-Ferrer, Noemi, Montepiedra, Grace, Mugusi, Ferdinand M., Owolabi, Olumuyiwa A., Parsonnet, Julie, Roach-Poblete, Freddy, Romeu-García, Maria Angeles, Spector, Stephen A., Sudfeld, Christopher R., Tenforde, Mark W., Togun, Toyin O., Yataco, Rosa, Zhang, Zibiao, Murray, Megan B.
    Publicado 2019
    “…CONCLUSION: Our findings suggest vitamin D predicts TB disease risk in a dose-dependent manner and that the risk of TB disease is highest among HIV-positive individuals with severe vitamin D deficiency. …”
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    Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis
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