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1381por Wu, Yifei, Li, Jincheng, Li, Chenmeijie, Lu, Shuai, Wei, Xiaoyu, Li, Yang, Xia, Wenjuan, Qian, Chunfeng, Wang, Zihang, Liu, Mingxi, Gu, Yayun, Huang, Boxian, Tan, Yueqiu, Hu, Zhibin“…Remarkably, we found that loss of Fto in mice caused spermatogenesis defects in an age-dependent manner, resulting from the attenuated proliferation ability of undifferentiated spermatogonia and increased male germ cell apoptosis. …”
Publicado 2023
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1382por Pan, Ling, Hu, Xu, Liao, Li, Xu, Tingchen, Sun, Quanquan, Tang, Minqiang, Chen, Zhenbang, Wang, ZhiyongEnlace del recurso
Publicado 2023
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1383por Kerr, Catherine M., Parthasarathy, Srivatsan, Schwarting, Nancy, O’Connor, Joseph J., Giri, Emily, More, Sunil, Orozco, Robin C., Fehr, Anthony R.Enlace del recurso
Publicado 2023
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1384“…CONCLUSIONS: FTO supports the formation of murine slow-twitch fibers in an NFATC1–YTHDF2 dependent manner. The consistent paraspinal muscle features seen in AIS and congenital scoliosis, as well as the reversible pattern of muscle fibers and expression of FTO in AIS suggest that FTO may contribute to the muscle fiber remodeling secondary to scoliosis. …”
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1385por Kejiou, Nevraj S, Ilan, Lena, Aigner, Stefan, Luo, Enching, Tonn, Tori, Ozadam, Hakan, Lee, Muyoung, Cole, Gregory B, Rabano, Ines, Rajakulendran, Nishani, Yee, Brian A, Najafabadi, Hamed S, Moraes, Trevor F, Angers, Stephane, Yeo, Gene W, Cenik, Can, Palazzo, Alexander FEnlace del recurso
Publicado 2023
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1386“…Furthermore, we have demonstrated that the E169 residue in the CCD mediates the release of the dimer from the DNA in an auto-inhibitory manner. CONCLUSION: Based on these findings, we propose a novel mechanism for the inactivation of the STAT1 signaling pathway, assigning the interface with the glutamic acid residue 169 in the CCD a crucial role in this process. …”
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1387“…The findings demonstrate that inulin exerts prebiotic effects, but in a sex-dependent manner. Overall, inulin increases the proportion of Bacteroides, Blautia, and glycine, while decreasing Eggerthella, Lactococcus, Streptococcus, trimethylamine, 3-hydroxyisobutyrate, leucine and methionine in both sexes. …”
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1388por Cheng, Yan, Dempsey, Rachael Elizabeth, Roodsari, Soheil Kazemi, Shuboni-Mulligan, Dorela D., George, Olivier, Sanford, Larry D., Guo, Ming-Lei“…Previous work showed that cocaine activates microglia in a region-specific manner in the brains of self-administered mice. To further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activity, corticotropin-releasing factor (CRF) signaling, and NF-κB levels in the striatum and hippocampus (HP). …”
Publicado 2023
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1389por Hsieh, En-Jung, Liao, Siao-Wei, Chang, Ching-Yuan, Tseng, Chu-Han, Wang, Shan-Li, Grillet, LouisEnlace del recurso
Publicado 2023
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1390por Wu, Zhelin, Yang, Yanjian, Li, Jiadong, Bossier, Peter, Wei, Xiayi, Guo, Zheng, Han, Biao, Ye, JianminEnlace del recurso
Publicado 2023
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1391por Jaber, Yasmin, Netanely, Yasmine, Naamneh, Reem, Saar, Or, Zubeidat, Khaled, Saba, Yasmin, Georgiev, Olga, Kles, Paz, Barel, Or, Horev, Yael, Yosef, Omri, Eli-Berchoer, Luba, Nadler, Chen, Betser-Cohen, Gili, Shapiro, Hagit, Elinav, Eran, Wilensky, Asaf, Hovav, Avi-Hai“…Mechanistically, masticatory forces induce the migration of LCs to the lymph nodes, and in return, LCs support the development of immunity to maintain epithelial integrity in a microbiota-independent manner. Unlike in adult life, this bone loss is IL-17-independent, suggesting that the establishment of oral mucosal homeostasis after birth and its maintenance in adult life involve distinct mechanisms.…”
Publicado 2023
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1392“…These data suggest that FA treatment shifts cellular energy metabolism in a substrate-specific manner, spares pyruvate carbon from oxidation, and stimulates glucose synthesis.…”
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1393por Zhang, Xin, He, Jiabao, Zhao, Ke, Liu, Shiqi, Xuan, Li, Chen, Shan, Xue, Rongtao, Lin, Ren, Xu, Jun, Zhang, Yan, Xiang, Andy Peng, Jin, Hua, Liu, QifaEnlace del recurso
Publicado 2023
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1394por Bunnell, Mary A, Lin, Patrick, Zhou, Sherry, Park, Chan Jin, Wang, Shuangqi, Hu, Qinan, Marzbanabbasabadi, Behrokh, Oh, Ji Eun, Wang, Bensen, Laws, Mary, Fletcher, Endia, Liu, Zhengde, Joo, Erica, Qiao, Huanyu, Flaws, Jodi, Ko, Chemyong“…In conclusion, prenatal exposure to a phthalate mixture alters the levels of T and E2 during fetal and neonatal EP in a gender-specific manner. Presentation: Thursday, June 15, 2023…”
Publicado 2023
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1395“…It is not clear if inhibiting the pro-death gene RNA binding motif 5 (RBM5) is neuroprotective in isolated primary neurons or if it regulates cell survival in a sex-dependent manner. Here we established sex-dichotomized primary cortical neuron cultures from transgenic mice harboring a floxed RBM5 gene-trap. …”
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1396“…While several studies have reported increases in EE/SE size and number resulting from endocytic events, few studies have addressed such dynamics in a methodological and quantitative manner. Herein we apply quantitative fluorescence microscopy to measure the size and number of EE/SE upon internalization of two different ligands: transferrin and epidermal growth factor. …”
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1397por Tokmina-Lukaszewska, Monika, Huang, Qi, Berry, Luke, Kallas, Hayden, Peters, John W., Seefeldt, Lance C., Raugei, Simone, Bothner, BrianEnlace del recurso
Publicado 2023
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1398“…The results clearly confirmed the enhancement of RMD rearrangement induced by proton and carbon irradiation in a dose- and LET-dependent manner. Meanwhile, RMD rearrangement was suppressed by intermolecular homology, in which the length of homology is more important than the composition of homology. …”
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