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1481
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1482por Qiu, Xiao, Wei, Rongfei, Li, Yang, Zhu, Qiong, Xiong, Cong, Chen, Yuhan, Zhang, Yuan, Lu, Kefeng, He, Fuchu, Zhang, Lingqiang“…These findings demonstrate that NEDL2 but not NEDL1 is required for ENS and kidney development in a unique Nedd8 ligase-dependent manner.…”
Publicado 2016
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1483“…Microglia, the resident macrophage-like cells in the central nervous system (CNS), are important contributors to neuroinflammation and, thus, we investigated if type II activated microglia could bias CD4(+) T cell responses in a similar manner as type II activated macrophages. Using immune complex ligation in the presence of LPS to induce type II activation, we found that both type II macrophages and type II microglia biased CD4(+) T cell responses in vitro to express increased levels of IL-17A and CD124. …”
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1484por Liu, Dan, Cao, Tuanping, Wang, Na, Liu, Chengfei, Ma, Ning, Tu, Ran, Min, Xiaoyun“…Administration of IL-25 could attenuate CIA development by Th17 suppression in an IL-13-dependent manner. Our findings indicate that IL-25 plays a potent immunosuppressive role in the pathogenesis of RA and CIA by downregulating Th17 cell response, and thus, may be a potential therapeutic agent for RA.…”
Publicado 2016
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1485por Salazar Vázquez, B. Y., Salazar Vázquez, M. A., López Gutiérrez, G., Acosta Rosales, K., Cabrales, P., Vadillo‐Ortega, F., Intaglietta, M., Pérez Tamayo, R., Schmid‐Schönbein, G. W.“…METHODS: Fifty‐four healthy individuals consisting of 18 adolescent girls and 36 boys aged 12 ± 2 years were given recommendations for reducing eating rate without changing diet or meal size according to the educational programme ‘good manners for a healthy future’. Each participant was provided with a 30‐s portable hourglass to pace time between bites. …”
Publicado 2015
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1486por Wang, Jing, Long, Cheng, Zhang, Haijun, Zhang, Yanan, Wang, Hao, Yue, Hongyuan, Wang, Xiaocui, Wu, Shugeng, Qi, Guanghai“…Variations in TMA and lipid metabolism were linked to the genetic variant in FMO3 in a diet-specific manner, which suggest FMO3 functions in TMA metabolism and lipid homeostasis. …”
Publicado 2016
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1487
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1488“…The smaller concentrations of SIL also decreased cAMP phosphodiesterase activity in a Ca(2+)/calmodulin-dependent manner. The stimulatory effects of SIL on GSIS were inhibited by three different inhibitors of exocytosis, indicating that SIL’s mechanism of stimulating GSIS operated via closing β-cell K-ATP channels, and perhaps more distal sites of action involving calcium influx and G-proteins. …”
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1489por Nakamura, Daisy S., Hollander, Judith M., Uchimura, Tomoya, Nielsen, Heber C., Zeng, Li“…CONCLUSION: We conclude that PEDF exacerbates cartilage degeneration in an age-dependent manner under an inflammatory setting. This is the first study identifying a specific role for PEDF in joint inflammation and highlights the multi-faceted activities of PEDF. …”
Publicado 2017
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1490por Mongon, Jenjira, Chaiwong, Nanthana, Bouain, Nadia, Prom-u-thai, Chanakan, Secco, David, Rouached, HatemEnlace del recurso
Publicado 2017
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1491“…Using gain-of-function and loss-of-function approaches, we show that SRGN promotes NSCLC cell migration and invasion as well as colonization in the lung and liver in a CD44-dependent manner. SRGN induces lung cancer cell stemness, as demonstrated by its ability to enhance NSCLC cell sphere formation via Nanog induction, accompanied with increased chemoresistance and anoikis-resistance. …”
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1492por Xu, Jingying, Ren, Xiuhai, Pathania, Anup Singh, Fernandez, G. Esteban, Tran, Anthony, Zhang, Yifu, Moats, Rex A., Shackleford, Gregory M., Erdreich-Epstein, AnatEnlace del recurso
Publicado 2017
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1493por Wolf-Grosse, Susann, Rokstad, Anne Mari, Ali, Syed, Lambris, John D, Mollnes, Tom E, Nilsen, Asbjørn M, Stenvik, Jørgen“…The IONPs activated complement, as measured by C3a, C5a and sC5b-9, and induced the production of pro-inflammatory cytokines in a particle-dose dependent manner, with the strongest response at 10 µg/mL IONPs. …”
Publicado 2017
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1494por Taylor, Oliver J., Thatcher, Mikayla O., Carr, Sheryl T., Gibbs, Jonathan L., Trumbull, Annie M., Harrison, Mitchell E., Winden, Duane R., Pearson, Mackenzie J., Tippetts, Trevor S., Holland, William L., Reynolds, Paul R., Bikman, Benjamin T.Enlace del recurso
Publicado 2017
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1495por Brown, K, Yang, P, Salvador, D, Kulikauskas, R, Ruohola-Baker, H, Robitaille, A M, Chien, A J, Moon, R T, Sherwood, VEnlace del recurso
Publicado 2017
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1496
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1497por Zhang, Bin, Shi, Xiaoting, Xu, Guifang, Kang, Wei, Zhang, Weijie, Zhang, Shu, Cao, Yu, Qian, Liping, Zhan, Ping, Yan, Hongli, To, Ka Fai, Wang, Lei, Zou, XiaopingEnlace del recurso
Publicado 2017
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1498por Fortuna, Rafael, Groeber, Martin, Seiberl, Wolfgang, Power, Geoffrey A., Herzog, Walter“…These findings provide evidence that stretch preceding shortening affects FD in a time‐ and speed‐dependent manner, providing new information on the potential mechanism of FD and RFE.…”
Publicado 2017
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1499por Bouchet, Courtney A., Lloyd, Brian A., Loetz, Esteban C., Farmer, Caroline E., Ostrovskyy, Mykola, Haddad, Natalie, Foright, Rebecca M., Greenwood, Benjamin N.“…Results indicate that exercise enhances consolidation of fear extinction memory and reduces fear relapse after extinction in a sex-dependent manner. These data suggest that brief bouts of exercise could be used as an augmentation strategy for exposure therapy, even in previously sedentary subjects. …”
Publicado 2017
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