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  1. 1641
    “…In conclusion, overexpression of EGLN1 promoted oncogenesis and induced a CSC-like phenotype in NPC cells, then enhancing the ability for radioresistance by interacting with p53 in a hydroxylase-dependent manner. Thus, EGLN1 might serve as a potential therapeutic target for NPC.…”
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    EGLN1 induces tumorigenesis and radioresistance in nasopharyngeal carcinoma by promoting ubiquitination of p53 in a hydroxylase-dependent manner
  2. 1642
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    No-ozone cold plasma can kill oral pathogenic microbes in H(2)O(2)-dependent and independent manner
  3. 1643
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    UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner
  4. 1644
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    CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner
  5. 1645
    “…In addition, ILF2 functions in a KLHDC7B-DT-dependent manner.…”
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    ILF2 Contributes to Hyperproliferation of Keratinocytes and Skin Inflammation in a KLHDC7B-DT-Dependent Manner in Psoriasis
  6. 1646
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    Berberine Alleviates Gastroesophageal Reflux-Induced Airway Hyperresponsiveness in a Transient Receptor Potential A1-Dependent Manner
  7. 1647
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    Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth
  8. 1648
    “…Intriguingly, the CpG motif within iSN40 was not required for its osteogenetic activity, indicating that iSN40 functions in a TLR9-independent manner. These data demonstrate that iSN40 serves as a novel osteogenetic ODN (osteoDN) that promotes osteoblast differentiation. iSN40 provides a potential seed of the nucleic acid drug that activating osteoblasts for osteoporosis therapy.…”
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    Identification of a Novel Osteogenetic Oligodeoxynucleotide (osteoDN) That Promotes Osteoblast Differentiation in a TLR9-Independent Manner
  9. 1649
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    The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner
  10. 1650
    “…CONCLUSIONS: These findings demonstrate that exposure to high concentrations of synthetic sugar substitutes alter proliferation and differentiation of gut epithelial cell lines in vitro, in a cell line-dependent manner. Additional research is necessary to determine whether these interactions also occur in vivo. …”
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    Synthetic Sugar Substitutes Alter Intestinal Epithelial Cell Proliferation and Differentiation in a Cell-Line Dependent Manner In Vitro
  11. 1651
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    Brain activations show association with subsequent endocrine responses to oral glucose challenge in a satiation-level dependent manner
  12. 1652
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    Human Trabecular Meshwork (HTM) Cells Treated with TGF-β2 or Dexamethasone Respond to Compression Stress in Different Manners
  13. 1653
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    Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner
  14. 1654
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    Loss of Unconventional Myosin VI Affects cAMP/PKA Signaling in Hindlimb Skeletal Muscle in an Age-Dependent Manner
  15. 1655
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    CsrD regulates amylovoran biosynthesis and virulence in Erwinia amylovora in a novel cyclic‐di‐GMP dependent manner
  16. 1656
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    TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner
  17. 1657
    “…In conclusion, the level of m(6)A modification is elevated in BPH; the METTL3/YTHDF2/PTEN axis disturbs the balance between epithelial proliferation and apoptosis, promotes EMT, and accelerates BPH development in an m(6)A modification-related manner.…”
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    METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner
  18. 1658
    “…Atorvastatin significantly inhibited the proliferative and tumorsphere-forming abilities of MKN45 GCSCs in a mevalonate pathway-independent manner. Atorvastatin induced cell cycle arrest at the G0/G1 phase and promoted apoptosis by activating the caspase cascade. …”
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    Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner
  19. 1659
    “…However, these CD142(+) ASPC‐specific properties exhibit surprising temporal phenotypic alterations, and emerge only in an age‐dependent manner. Finally, using multi‐omic and functional assays, we show that the inhibitory nature of these adipogenesis‐regulatory CD142(+) ASPCs (Aregs) is driven by specifically expressed secretory factors that cooperate with the retinoic acid signalling pathway to transform the adipogenic state of CD142(−) ASPCs into a non‐adipogenic, Areg‐like state.…”
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    Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner
  20. 1660
    Publicado 2022
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    SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner [Retraction]
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