Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy

por Cheng, Xiaobei, Yu, Pei, Zhou, Xiang, Zhu, Jiale, Han, Yubao, Zhang, Chao, Kong, Lingyi
Publicado 2022

Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells

por Zhang, Qiufen, Chen, Yingyi, Ni, Duan, Huang, Zhimin, Wei, Jiacheng, Feng, Li, Su, Jun-Cheng, Wei, Yingqing, Ning, Shaobo, Yang, Xiuyan, Zhao, Mingzhu, Qiu, Yuran, Song, Kun, Yu, Zhengtian, Xu, Jianrong, Li, Xinyi, Lin, Houwen, Lu, Shaoyong, Zhang, Jian
Publicado 2022

Emodin-Mediated Treatment of Acute Kidney Injury

por Liu, Yu, Li, Mingquan, Teh, LaiKuan, Zhao, Liangbin, Ye, Naijing, Wu, Ling, Wu, Lihua
Publicado 2022

Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis

por Song, Meiyue, Wang, Jiaxin, Sun, Youliang, Pang, Junling, Li, Xiaona, Liu, Yuan, Zhou, Yitian, Yang, Peiran, Fan, Tianhui, Liu, Ying, Li, Zhaoguo, Qi, Xianmei, Li, Baicun, Zhang, Xinri, Wang, Jing, Wang, Chen
Publicado 2022

Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner

por Zheng, Cancan, Yu, Xiaomei, Liang, Yiyao, Zhu, Yidong, He, Yan, Liao, Long, Wang, Dingkang, Yang, Yanming, Yin, Xingfeng, Li, Ang, He, Qingyu, Li, Bin
Publicado 2022

Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

por Wang, Fangfang, Jin, Sora, Mayca Pozo, Franklin, Tian, Danmei, Tang, Xiyang, Dai, Yi, Yao, Xinsheng, Tang, Jinshan, Zhang, Youwei
Publicado 2022

Chiral mesoporous silica nano-screws as an efficient biomimetic oral drug delivery platform through multiple topological mechanisms

por Wang, Yumei, Ke, Jia, Guo, Xianmou, Gou, Kaijun, Sang, Zhentao, Wang, Yanbu, Bian, Yan, Li, Sanming, Li, Heran
Publicado 2022

The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

por Ye, Geni, Huang, Maohua, Li, Yong, Ouyang, Jie, Chen, Minfeng, Wen, Qing, Li, Xiaobo, Zeng, Huhu, Long, Pei, Fan, Zepei, Yin, Junqiang, Ye, Wencai, Zhang, Dongmei
Publicado 2022

Free energy perturbation (FEP)-guided scaffold hopping

por Wu, Deyan, Zheng, Xuehua, Liu, Runduo, Li, Zhe, Jiang, Zan, Zhou, Qian, Huang, Yue, Wu, Xu-Nian, Zhang, Chen, Huang, Yi-You, Luo, Hai-Bin
Publicado 2022

Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis

por Chen, Ting, Zhuang, Bo, Huang, Yueqi, Liu, Yan, Yuan, Bochuan, Wang, Wanmei, Yuan, Tianyu, Du, Lina, Jin, Yiguang
Publicado 2022

Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases

por Guan, Baoyi, Tong, Jinlin, Hao, Haiping, Yang, Zhixu, Chen, Keji, Xu, Hao, Wang, Anlu
Publicado 2022

Inhibition of intracellular proton-sensitive Ca(2+)-permeable TRPV3 channels protects against ischemic brain injury

por Chen, Xiaoling, Zhang, Jingliang, Wang, KeWei
Publicado 2022

Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism

por Maharjan, Abi, Sun, Hongyu, Cao, Zeying, Li, Ke, Liu, Jinping, Liu, Jun, Xiao, Tiqiao, Peng, Guanyun, Ji, Junqiu, York, Peter, Regmi, Balmukunda, Yin, Xianzhen, Zhang, Jiwen, Wu, Li
Publicado 2022

Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis

por Wang, Gan, Zhang, Min, Meng, Ping, Long, Chengbo, Luo, Xiaodong, Yang, Xingwei, Wang, Yunfei, Zhang, Zhiye, Mwangi, James, Kamau, Peter Muiruri, Dai, Zhi, Ke, Zunfu, Zhang, Yi, Chen, Wenlin, Zhao, Xudong, Ge, Fei, Lv, Qiumin, Rong, Mingqiang, Li, Dongsheng, Jin, Yang, Sheng, Xia, Lai, Ren
Publicado 2022

Drug discovery of sclerostin inhibitors

por Yu, Sifan, Li, Dijie, Zhang, Ning, Ni, Shuaijian, Sun, Meiheng, Wang, Luyao, Xiao, Huan, Liu, Dingdong, Liu, Jin, Yu, Yuanyuan, Zhang, Zongkang, Yeung, Samuel Tin Yui, Zhang, Shu, Lu, Aiping, Zhang, Zhenlin, Zhang, Baoting, Zhang, Ge
Publicado 2022

Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy

por Ye, Jiayi, Hou, Bo, Chen, Fangmin, Zhang, Shunan, Xiong, Muya, Li, Tianliang, Xu, Yechun, Xu, Zhiai, Yu, Haijun
Publicado 2022

YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer

por Lai, Fangfang, Ji, Ming, Huang, Lei, Wang, Yunchen, Xue, Nina, Du, Tingting, Dong, Kai, Yao, Xiaoqing, Jin, Jing, Feng, Zhiqiang, Chen, Xiaoguang
Publicado 2022

Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma

por Xue, Jiao, Zhu, Yining, Bai, Shuting, He, Chunting, Du, Guangsheng, Zhang, Yuandong, Zhong, Yao, Chen, Wenfei, Wang, Hairui, Sun, Xun
Publicado 2022

NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion

por Wu, Ying, Pu, Congying, Fu, Yixian, Dong, Guoqiang, Huang, Min, Sheng, Chunquan
Publicado 2022

Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

por Wu, Fuhua, Luo, Shuang, Zhang, Yongshun, Ou, Yangsen, Wang, Hairui, Guo, Zhaofei, He, Chunting, Bai, Shuting, He, Penghui, Jiang, Min, Chen, Xiaoyan, Du, Guangsheng, Sun, Xun
Publicado 2023