Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing

por Neupane, Yub Raj, Handral, Harish K., Alkaff, Syed Abdullah, Chng, Wei Heng, Venkatesan, Gopalakrishnan, Huang, Chenyuan, Lee, Choon Keong, Wang, Jiong-Wei, Sriram, Gopu, Dienzo, Rhonnie Austria, Lu, Wen Feng, Ali, Yusuf, Czarny, Bertrand, Pastorin, Giorgia
Publicado 2023

The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses

por Wu, Kan Xing, Yogarajah, Thinesshwary, Loe, Marcus Wing Choy, Kaur, Parveen, Lee, Regina Ching Hua, Mok, Chee Keng, Wong, Yi Hao, Phuektes, Patchara, Yeo, Li Sze, Chow, Vincent T.K., Tan, Yong Wah, Chu, Justin Jang Hann
Publicado 2023

Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression

por Tang, Chuanfeng, Wang, Qiaona, Shen, Jingyan, Wang, Congying, Ding, Hong, Wen, Shiyu, Yang, Fan, Jiao, Ruiqing, Wu, Xingxin, Li, Jianmei, Kong, Lingdong
Publicado 2023

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

por Hu, Chuan, Song, Yujun, Zhang, Yiwei, He, Siqin, Liu, Xueying, Yang, Xiaotong, Gong, Tao, Huang, Yuan, Gao, Huile
Publicado 2023

HR121 targeting HR2 domain in S2 subunit of spike protein can serve as a broad-spectrum SARS-CoV-2 inhibitor via intranasal administration

por Lu, Ying, Shen, Fan, He, Wen-Qiang, Li, An-Qi, Li, Ming-Hua, Feng, Xiao-Li, Zheng, Yong-Tang, Pang, Wei
Publicado 2023

Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations

por Shi, Chen, Zhang, Cong, Fu, Zhiwen, Liu, Jinmei, Zhou, Yuanfeng, Cheng, Bao, Wang, Cong, Li, Shijun, Zhang, Yu
Publicado 2023

Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations

por Li, Pengyun, Jia, Changkai, Fan, Zhiya, Hu, Xiaotong, Zhang, Wenjuan, Liu, Ke, Sun, Shiyang, Guo, Haoxin, Yang, Ning, Zhu, Maoxiang, Zhuang, Xiaomei, Xiao, Junhai, Zheng, Zhibing, Li, Song
Publicado 2023

Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A(2A/2B) receptors in tolerogenic dendritic cells

por Shi, Gaona, Zhou, Yu, Liu, Wenshuai, Chen, Chengjuan, Wei, Yazi, Yan, Xinlong, Wu, Lei, Wang, Weiwei, Sun, Lan, Zhang, Tiantai
Publicado 2023

ETCM v2.0: An update with comprehensive resource and rich annotations for traditional Chinese medicine

por Zhang, Yanqiong, Li, Xin, Shi, Yulong, Chen, Tong, Xu, Zhijian, Wang, Ping, Yu, Meng, Chen, Wenjia, Li, Bing, Jing, Zhiwei, Jiang, Hong, Fu, Lu, Gao, Wenjing, Jiang, Yanhua, Du, Xia, Gong, Zipeng, Zhu, Weiliang, Yang, Hongjun, Xu, Haiyu
Publicado 2023

Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis

por Yu, Qian, Li, Chang, Niu, Qinghui, Wang, Jigang, Che, Zhaodi, Lei, Ke, Ren, He, Ma, Boyi, Ren, Yixing, Luo, Pingping, Fan, Zhuming, Zhang, Huan, Liu, Zhaohui, Tipoe, George L., Xiao, Jia
Publicado 2023

Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA

por Zhang, Wenxin, Pan, Xiaohui, Xu, Yanjun, Guo, Hongjie, Zheng, Mingming, Chen, Xi, Wu, Honghai, Luan, Fengming, He, Qiaojun, Ding, Ling, Yang, Bo
Publicado 2023

Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

por Peng, Kezheng, Zeng, Chenye, Gao, Yuqi, Liu, Binliang, Li, Liyuan, Xu, Kang, Yin, Yuemiao, Qiu, Ying, Zhang, Mingkui, Ma, Fei, Wang, Zhao
Publicado 2023

Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

por Wang, Xiaomin, Xu, Jun, Sun, Yiming, Cao, Siyuwei, Zeng, Hanlin, Jin, Nan, Shou, Matthew, Tang, Shuai, Chen, Yi, Huang, Min
Publicado 2023

Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 via biosensors

por Ma, Lijuan, Li, Boyi, Ma, Jinchen, Wu, Chunyuan, Li, Nan, Zhou, Kailin, Yan, Yun, Li, Mingshuang, Hu, Xiaoyan, Yan, Hao, Wang, Qi, Zheng, Yanfei, Wu, Zhisheng
Publicado 2023

MF-SuP-pK(a): Multi-fidelity modeling with subgraph pooling mechanism for pK(a) prediction

por Wu, Jialu, Wan, Yue, Wu, Zhenxing, Zhang, Shengyu, Cao, Dongsheng, Hsieh, Chang-Yu, Hou, Tingjun
Publicado 2023

A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression

por Zhou, Yi, Miao, Yingling, Huang, Qiudi, Shi, Wenwen, Xie, Jiacui, Lin, Jiachang, Huang, Pei, Yue, Chengfeng, Qin, Yuan, Yu, Xiyong, Wang, He, Qin, Linghao, Chen, Jianhai
Publicado 2023

GPRC5B protects osteoarthritis by regulation of autophagy signaling

por He, Liang, Xu, Ziwei, Niu, Xin, Li, Rong, Wang, Fanhua, You, Yu, Gao, Jingduo, Zhao, Lei, Shah, Karan M., Fan, Jian, Liu, Mingyao, Luo, Jian
Publicado 2023

Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and rep...

por Tong, Fan, Hu, Haili, Xu, Yanyan, Zhou, Yang, Xie, Rou, Lei, Ting, Du, Yufan, Yang, Wenqin, He, Siqin, Huang, Yuan, Gong, Tao, Gao, Huile
Publicado 2023

Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B

por Liu, Haowei, Huang, Qiuming, Fan, Yunqi, Li, Bo, Liu, Xuemei, Hu, Changhua
Publicado 2023

Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy

por Yue, Xin, Liu, Tingyu, Wang, Xuecen, Wu, Weijian, Wen, Gesi, Yi, Yang, Wu, Jiaxin, Wang, Ziyang, Zhan, Weixiang, Wu, Ruirui, Meng, Yuan, Cao, Zhirui, Le, Liyuan, Qiu, Wenyan, Zhang, Xiaoyue, Li, Zhenyu, Chen, Yong, Wan, Guohui, Bu, Xianzhang, Peng, Zhenwei, Liu, Ran-yi
Publicado 2023