A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis

por He, Tailin, Shang, Jialin, Gao, Chenglong, Guan, Xin, Chen, Yingyi, Zhu, Liwen, Zhang, Luyong, Zhang, Cunjin, Zhang, Jian, Pang, Tao
Publicado 2021

S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling

por Luo, Pingping, Zheng, Ming, Zhang, Rui, Zhang, Hong, Liu, Yingxia, Li, Wei, Sun, Xiaoming, Yu, Qian, Tipoe, George L., Xiao, Jia
Publicado 2021

Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation

por Gao, Yue, Fan, Shicheng, Li, Hua, Jiang, Yiming, Yao, Xinpeng, Zhu, Shuguang, Yang, Xiao, Wang, Ruimin, Tian, Jianing, Gonzalez, Frank J., Huang, Min, Bi, Huichang
Publicado 2021

Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing

por Wang, Zhiru, Kang, Wenting, Li, Ouwen, Qi, Fengyu, Wang, Junwei, You, Yinghua, He, Pengxing, Suo, Zhenhe, Zheng, Yichao, Liu, Hong-Min
Publicado 2021

Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications

por Gao, Peng, Chang, Xin, Zhang, Dagan, Cai, Yafei, Chen, Gen, Wang, Hao, Wang, Tianfu
Publicado 2021

Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma

por Zhang, Shouyue, Zhang, Jin, An, Yang, Zeng, Xiaoxi, Qin, Ziyi, Zhao, Yuqian, Xu, Heng, Liu, Bo
Publicado 2021

SMYD3–PARP16 axis accelerates unfolded protein response and mediates neointima formation

por Long, Fen, Yang, Di, Wang, Jinghua, Wang, Qing, Ni, Ting, Wei, Gang, Zhu, Yizhun, Liu, Xinhua
Publicado 2021

Development of a highly-specific (18)F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

por Chen, Zhen, Mori, Wakana, Rong, Jian, Schafroth, Michael A., Shao, Tuo, Van, Richard S., Ogasawara, Daisuke, Yamasaki, Tomoteru, Hiraishi, Atsuto, Hatori, Akiko, Chen, Jiahui, Zhang, Yiding, Hu, Kuan, Fujinaga, Masayuki, Sun, Jiyun, Yu, Qingzhen, Collier, Thomas L., Shao, Yihan, Cravatt, Benjamin F., Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Publicado 2021

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

por Van Anh, Tran Thi, Mostafa, Alilou, Rao, Zhigang, Pace, Simona, Schwaiger, Stefan, Kretzer, Christian, Temml, Veronika, Giesel, Carsten, Jordan, Paul M., Bilancia, Rossella, Weinigel, Christina, Rummler, Silke, Waltenberger, Birgit, Hung, Tran, Rossi, Antonietta, Stuppner, Hermann, Werz, Oliver, Koeberle, Andreas
Publicado 2021

Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

por Ding, Lili, Yang, Qiaoling, Zhang, Eryun, Wang, Yangmeng, Sun, Siming, Yang, Yingbo, Tian, Tong, Ju, Zhengcai, Jiang, Linshan, Wang, Xunjiang, Wang, Zhengtao, Huang, Wendong, Yang, Li
Publicado 2021

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

por Liu, Ying, Song, Zan, Liu, Yajie, Ma, Xubin, Wang, Wang, Ke, Yu, Xu, Yichao, Yu, Dequan, Liu, Hongmin
Publicado 2021

Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China

por Wang, Zhiqiang, Zhang, Zhibo, Li, Yong, Sun, Li, Peng, Dezhen, Du, Danyu, Zhang, Xian, Han, Luwei, Zhao, Liwen, Lu, Ligong, Du, Hongzhi, Yuan, Shengtao, Zhan, Meixiao
Publicado 2021

A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases

por Zhou, Jie, Xu, Wei, Liu, Zezhong, Wang, Chao, Xia, Shuai, Lan, Qiaoshuai, Cai, Yanxing, Su, Shan, Pu, Jing, Xing, Lixiao, Xie, Youhua, Lu, Lu, Jiang, Shibo, Wang, Qian
Publicado 2022

Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy

por Yu, Ling, Wang, Zhenjie, Mo, Zhuomao, Zou, Binhua, Yang, Yuanyuan, Sun, Rui, Ma, Wen, Yu, Meng, Zhang, Shijun, Yu, Zhiqiang
Publicado 2021

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

por Wu, Xu, Yin, Chun, Ma, Jiang, Chai, Stella, Zhang, Chunyuan, Yao, Sheng, Kadioglu, Onat, Efferth, Thomas, Ye, Yang, To, Kenneth Kin-Wah, Lin, Ge
Publicado 2021

Protective effects of VMY-2-95 on corticosterone-induced injuries in mice and cellular models

por Yu, Ziru, Kong, Dewen, Liang, Yu, Zhao, Xiaoyue, Du, Guanhua
Publicado 2021

AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptopha...

por Dai, Qingqing, Yan, Yuhang, Ning, Xiangli, Li, Gen, Yu, Junlin, Deng, Ji, Yang, Lingling, Li, Guo-Bo
Publicado 2021

Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

por Wu, Canhao, Xu, Qin, Wang, Huiyuan, Tu, Bin, Zeng, Jiaxin, Zhao, Pengfei, Shi, Mingjie, Qiu, Hong, Huang, Yongzhuo
Publicado 2022

Advances in Chemical Constituents, Clinical Applications, Pharmacology, Pharmacokinetics and Toxicology of Erigeron breviscapus

por Wu, Ruixia, Liang, Yan, Xu, Min, Fu, Ke, Zhang, Yangliu, Wu, Lei, Wang, Zhang
Publicado 2021

Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRAS(G12C)

por Li, Cuicui, Zhao, Ni, An, Luyan, Dai, Zhen, Chen, Xiaoyi, Yang, Fan, You, Qidong, Di, Bin, Hu, Chi, Xu, Lili
Publicado 2021