Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes

por Tao, Wenhui, Zhao, Dongyang, Li, Guanting, Li, Lingxiao, Li, Songhao, Ye, Hao, Tian, Chutong, Lu, Yutong, Li, Shuying, Sun, Yinghua, He, Zhonggui, Sun, Jin
Publicado 2022

Discovery and development of brain-penetrant (18)F-labeled radioligands for neuroimaging of the sigma-2 receptors

por Zhang, Ying, Wang, Tao, Zhang, Xiaojun, Deuther-Conrad, Winnie, Fu, Hualong, Cui, Mengchao, Zhang, Jinming, Brust, Peter, Huang, Yiyun, Jia, Hongmei
Publicado 2022

NF-κB regulates brown adipocyte function through suppression of ANT2

por Peng, Shiqiao, Zhang, Xiaoying, Yu, Lili, Xu, Yanhong, Zhou, Yang, Qian, Shengnan, Cao, Xinyu, Ye, Xiaotong, Yang, Jiajun, Jia, Weiping, Ye, Jianping
Publicado 2022

Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling

por Wu, Yunhao, Yu, Xiu, Wang, Yuwei, Huang, Yalin, Tang, Jiahui, Gong, Shuaishuai, Jiang, Siyu, Xia, Yuanli, Li, Fang, Yu, Boyang, Zhang, Yuanyuan, Kou, Junping
Publicado 2022

The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation

por Fan, Zhiwei, Wu, Changyue, Chen, Miaomiao, Jiang, Yongying, Wu, Yuanyuan, Mao, Renfang, Fan, Yihui
Publicado 2022

Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1–PI3K/AKT pathway

por He, Yingzi, Zheng, Zhiwei, Liu, Chang, Li, Wen, Zhao, Liping, Nie, Guohui, Li, Huawei
Publicado 2022

WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

por Gao, Xiaomeng, You, Jieqiong, Gong, Yanling, Yuan, Meng, Zhu, Haiying, Fang, Liang, Zhu, Hong, Ying, Meidan, He, Qiaojun, Yang, Bo, Cao, Ji
Publicado 2022

c-MYC-mediated TRIB3/P62(+) aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

por Su, Min-Xia, Xu, Yu-Lian, Jiang, Xiao-Ming, Huang, Mu-Yang, Zhang, Le-Le, Yuan, Luo-Wei, Xu, Xiao-Huang, Zhu, Qi, Gao, Jian-Li, Lu, Jia-Hong, Chen, Xiuping, Huang, Ming-Qing, Wang, Yitao, Lu, Jin-Jian
Publicado 2022

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors

por Rioja-Blanco, Elisa, Arroyo-Solera, Irene, Álamo, Patricia, Casanova, Isolda, Gallardo, Alberto, Unzueta, Ugutz, Serna, Naroa, Sánchez-García, Laura, Quer, Miquel, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramon, Alba-Castellón, Lorena, León, Xavier
Publicado 2022

One-step synthesis of site-specific antibody–drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates

por Shi, Wei, Li, Wanzhen, Zhang, Jianxin, Li, Tiehai, Song, Yakai, Zeng, Yue, Dong, Qian, Lin, Zeng, Gong, Likun, Fan, Shuquan, Tang, Feng, Huang, Wei
Publicado 2022

Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment

por Zhu, Di, Lu, Yu, Gui, Lin, Wang, Wenjing, Hu, Xi, Chen, Su, Wang, Yanming, Wang, Yuji
Publicado 2022

The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway

por Yu, Weimin, Xu, Gang, Chen, Hui, Xiao, Li, Liu, Gang, Hu, Pingping, Li, Siqi, Kasim, Vivi, Zeng, Chunyu, Tong, Xiaoyong
Publicado 2022

Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

por Luo, Piao, Liu, Dandan, Zhang, Qian, Yang, Fan, Wong, Yin-Kwan, Xia, Fei, Zhang, Junzhe, Chen, Jiayun, Tian, Ya, Yang, Chuanbin, Dai, Lingyun, Shen, Han-Ming, Wang, Jigang
Publicado 2022

Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood

por Chen, Shuzhen, Dong, Yaping, Qi, Xinming, Cao, Qiqi, Luo, Tao, Bai, Zhaofang, He, Huisi, Fan, Zhecai, Xu, Lingyan, Xing, Guozhen, Wang, Chunyu, Jin, Zhichao, Li, Zhixuan, Chen, Lei, Zhong, Yishan, Wang, Jiao, Ge, Jia, Xiao, Xiaohe, Bian, Xiuwu, Wen, Wen, Ren, Jin, Wang, Hongyang
Publicado 2022

Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB–P300–BRD4 axis

por Li, Xuesong, Zhu, Ruigong, Jiang, Hong, Yin, Quanwen, Gu, Jiaming, Chen, Jiajing, Ji, Xian, Wu, Xuan, Fu, Haiping, Wang, Hui, Tang, Xin, Gao, Yuanqing, Wang, Bingjian, Ji, Yong, Chen, Hongshan
Publicado 2022

Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety

por Gao, Wei, Hu, Hongxiang, Dai, Lipeng, He, Miao, Yuan, Hebao, Zhang, Huixia, Liao, Jinhui, Wen, Bo, Li, Yan, Palmisano, Maria, Traore, Mohamed Dit Mady, Zhou, Simon, Sun, Duxin
Publicado 2022

Enhancing cancer chemo-immunotherapy by biomimetic nanogel with tumor targeting capacity and rapid drug-releasing in tumor microenvironment

por Shang, Lihuan, Jiang, Xue, Yang, Ting, Xu, Hongbo, Xie, Qi, Hu, Mei, Yang, Conglian, Kong, Li, Zhang, Zhiping
Publicado 2022

Equisetin is an anti-obesity candidate through targeting 11β-HSD1

por Xu, Zhenlu, Liu, Dongyun, Liu, Dong, Ren, Xue, Liu, Haibo, Qi, Guihong, Zhou, Yue, Wu, Chongming, Zhu, Kui, Zou, Zhongmei, Yuan, Jing, Lin, Wenhan, Guo, Peng
Publicado 2022

Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism

por Xiao, Haiming, Sun, Xiaohong, Lin, Zeyuan, Yang, Yan, Zhang, Meng, Xu, Zhanchi, Liu, Peiqing, Liu, Zhongqiu, Huang, Heqing
Publicado 2022

Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway

por Du, Xiliang, Di Malta, Chiara, Fang, Zhiyuan, Shen, Taiyu, Niu, Xiaodi, Chen, Meng, Jin, Bo, Yu, Hao, Lei, Lin, Gao, Wenwen, Song, Yuxiang, Wang, Zhe, Xu, Chuang, Cao, Zhijun, Liu, Guowen, Li, Xinwei
Publicado 2022