Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy

por Cen, Xiaohong, Wang, Baoqu, Liang, Yuqing, Chen, Yanlin, Xiao, Yu, Du, Shaohua, Nandakumar, Kutty Selva, Yin, Hang, Liu, Shuwen, Cheng, Kui
Publicado 2022

Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis

por Wang, Feixia, Li, Zhanghao, Chen, Li, Yang, Ting, Liang, Baoyu, Zhang, Zili, Shao, Jiangjuan, Xu, Xuefen, Yin, Guoping, Wang, Shijun, Ding, Hai, Zhang, Feng, Zheng, Shizhong
Publicado 2022

Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase

por Zhou, Xiaoqing, Zhao, Shaoyang, Liu, Tingting, Yao, Lu, Zhao, Meimei, Ye, Xiaoming, Zhang, Xiaowen, Guo, Qiang, Tu, Pengfei, Zeng, Kewu
Publicado 2022

Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability

por Lei, Xueping, Li, Zhan, Zhong, Yihang, Li, Songpei, Chen, Jiacong, Ke, Yuanyu, Lv, Sha, Huang, Lijuan, Pan, Qianrong, Zhao, Lixin, Yang, Xiangyu, Chen, Zisheng, Deng, Qiudi, Yu, Xiyong
Publicado 2022

Coordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy

por Yang, Xuan, Wang, Yalong, Zhao, Junke, Rong, Hehui, Chen, Yujun, Xiong, Mengting, Ye, Xiaoxing, Yu, Shihui, Hu, Haiyan
Publicado 2022

Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications

por Zou, Ling, Liao, Minru, Zhen, Yongqi, Zhu, Shiou, Chen, Xiya, Zhang, Jin, Hao, Yue, Liu, Bo
Publicado 2022

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

por Xu, Suo-wen, Ilyas, Iqra, Weng, Jian-ping
Publicado 2022

The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs—Therapeutic potential exploration in lung injury

por Pang, Juan, Feng, Jia Nuo, Ling, Wenhua, Jin, Tianru
Publicado 2022

A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer

por Li, Yan, Chu, Ya, Shi, Guangjiang, Wang, Xiaobin, Ye, Wanli, Shan, Chun, Wang, Dajia, Zhang, Di, He, Wei, Jiang, Jingwei, Ma, Shuqian, Han, Yuhong, Zhao, Zhili, Du, Shijia, Chen, Zhen, Li, Zhiyu, Yang, Yong, Wang, Chen, Xu, Xi, Wu, Hongxi
Publicado 2022

Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy

por Zhou, Zaigang, Chen, Jiashe, Liu, Yu, Zheng, Chunjuan, Luo, Wenjuan, Chen, Lele, Zhou, Shen, Li, Zhiming, Shen, Jianliang
Publicado 2022

Identification of Q-Markers from Hedan Tablet by employing “spider-web” mode and taking compounds’ hepatotoxicity into account

por Wang, Danni, Ding, Jiamin, Feng, Xiafei, Chai, Xin, Yang, Jing, Liu, Chunlei, Zeng, Yingzi, Zhou, Wanhui, Wang, Yuefei
Publicado 2022

Evolution of drug regulations and regulatory innovation for anticancer drugs in China

por Liu, Yang, Zhang, Ning, Xie, Cuicui, Jiang, Yale, Qin, Yunhe, Zhou, Liyun, Fan, Yi, Ren, Lianjie, Yin, Chen, Yang, Huan, Xie, Wei, Zhai, Qing, Li, Guanqiao, Chen, Hongzhuan, Chen, Xiaoyuan
Publicado 2022

Biodegradable calcium sulfide-based nanomodulators for H(2)S-boosted Ca(2+)-involved synergistic cascade cancer therapy

por Lin, Chuchu, Huang, Chenyi, Shi, Zhaoqing, Ou, Meitong, Sun, Shengjie, Yu, Mian, Chen, Ting, Yi, Yunfei, Ji, Xiaoyuan, Lv, Feng, Wu, Meiying, Mei, Lin
Publicado 2022

Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

por Sun, Chengliang, Cheng, Yao, Liu, Xiaojia, Wang, Gefei, Min, Wenjian, Wang, Xiao, Yuan, Kai, Hou, Yi, Li, Jiaxing, Zhang, Haolin, Dong, Haojie, Wang, Liping, Lou, Chenguang, Sun, Yanze, Yu, Xinmiao, Deng, Hongbin, Xiao, Yibei, Yang, Peng
Publicado 2022

Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB /IL-6/STAT3 and JNK/PTX3 pathways

por Li, Wan, Cai, Hongqing, Ren, Liwen, Yang, Yihui, Yang, Hong, Liu, Jinyi, Li, Sha, Zhang, Yizhi, Zheng, Xiangjin, Tan, Wei, Du, Guanhua, Wang, Jinhua
Publicado 2022

Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules

por Ma, Yan-hong, Hong, Xu, Wu, Fang, Xu, Xin-feng, Li, Rui, Zhong, Jin, Zhou, Yao-qi, Liu, Shu-wen, Zhan, Jian, Xu, Wei
Publicado 2023

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

por Sun, Mingming, Li, Leilei, Niu, Yujia, Wang, Yingzhi, Yan, Qi, Xie, Fei, Qiao, Yaya, Song, Jiaqi, Sun, Huanran, Li, Zhen, Lai, Sizhen, Chang, Hongkai, Zhang, Han, Wang, Jiyan, Yang, Chenxin, Zhao, Huifang, Tan, Junzhen, Li, Yanping, Liu, Shuangping, Lu, Bin, Liu, Min, Kong, Guangyao, Zhao, Yujun, Zhang, Chunze, Lin, Shu-Hai, Luo, Cheng, Zhang, Shuai, Shan, Changliang
Publicado 2023

Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

por Lin, Yubi, Liu, Ruonan, Huang, Yanling, Yang, Zhe, Xian, Jianzhong, Huang, Jingmin, Qiu, Zirui, Lin, Xiufang, Zhang, Mengzhen, Chen, Hui, Wang, Huadong, Huang, Jiana, Xu, Geyang
Publicado 2023

A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy

por Chu, Yongchao, Luo, Yifan, Su, Boyu, Li, Chao, Guo, Qin, Zhang, Yiwen, Liu, Peixin, Chen, Hongyi, Zhao, Zhenhao, Zhou, Zheng, Wang, Yu, Jiang, Chen, Sun, Tao
Publicado 2023

Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation

por Che, Zhaodi, Song, Yali, Xu, Chengfang, Li, Wei, Dong, Zhiyong, Wang, Cunchuan, Ren, Yixing, So, Kwok-Fai, Tipoe, George L., Wang, Fei, Xiao, Jia
Publicado 2023