Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cho...

por Hong, Shijin, Li, Shuai, Meng, Xiaoyan, Li, Ping, Wang, Xun, Su, Mengxiang, Liu, Xiaodong, Liu, Li
Publicado 2023

Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity

por Prather, Benjamin L., Ji, Shuyue, Zhao, Yue, Shajan, Femil Joseph, Zhao, Mi, Buuh, Zakey Yusuf, Maloney, Robert, Zhang, Rui, Cohen, Carson, Wang, Rongsheng E.
Publicado 2023

Late-stage cascade of oxidation reactions during the biosynthesis of oxalicine B in Penicillium oxalicum

por Zhang, Tao, Gu, Guowei, Liu, Guodong, Su, Jinhua, Zhan, Zhilai, Zhao, Jianyuan, Qian, Jinxiu, Cai, Guowei, Cen, Shan, Zhang, Dewu, Yu, Liyan
Publicado 2023

Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation

por Nie, Qiang, Li, Chenwen, Wang, Yu, Hu, Yi, Pu, Wendan, Zhang, Qixiong, Cai, Jiajun, Lin, Yongyao, Li, Gang, Wang, Chenping, Li, Lanlan, Dou, Yin, Zhang, Jianxiang
Publicado 2023

Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virus-induced oxidative stress

por Kwon, Eun-Bin, Li, Wei, Kim, Young Soo, Kim, Buyun, Chung, Hwan-Suck, Go, Younghoon, Ko, Hyun-Jeong, Song, Jae-Hyoung, Kim, Young Ho, Choi, Chun Whan, Choi, Jang-Gi
Publicado 2023

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

por Vidal-Torres, Alba, Fernández-Pastor, Begoña, García, Mónica, Ayet, Eva, Cabot, Anna, Burgueño, Javier, Monroy, Xavier, Aubel, Bertrand, Codony, Xavier, Romero, Luz, Pascual, Rosalía, Serafini, Maria Teresa, Encina, Gregorio, Almansa, Carmen, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel
Publicado 2023

Targeting macrophagic 17β-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease

por Dong, Xiaoyu, Feng, Yiting, Xu, Dongqin, Zhang, Mengya, Wen, Xiao, Zhao, Wenhao, Hu, Qintong, Zhang, Qinyong, Fu, Hui, Ping, Jie
Publicado 2023

Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy

por Cheng, Jianjun, Zhao, Haitian, Li, Bin, Zhang, Hua, Zhao, Qianyu, Fu, Shiyao, Han, Ying, Lu, Weihong, Shi, Jiahua, Yang, Xin
Publicado 2023

Salmonella-mediated blood‒brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

por Mi, Ze, Yao, Qing, Qi, Yan, Zheng, Jinhai, Liu, Jiahao, Liu, Zhenguo, Tan, Hongpei, Ma, Xiaoqian, Zhou, Wenhu, Rong, Pengfei
Publicado 2023

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

por Gan, Changpei, Wang, Jing, Martínez-Chávez, Alejandra, Hillebrand, Michel, de Vries, Niels, Beukers, Joke, Wagenaar, Els, Wang, Yaogeng, Lebre, Maria C., Rosing, Hilde, Klarenbeek, Sjoerd, Ali, Rahmen Bin, Pritchard, Colin, Huijbers, Ivo, Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2023

Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice

por Song, Nazi, Xu, Hongjiao, Wu, Shuohan, Luo, Suijia, Xu, Jingyao, Zhao, Qian, Wang, Rui, Jiang, Xianxing
Publicado 2023

Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

por Feng, Yin, Han, Yefan, Hu, Anni, Qu, Yi, Hu, Yili, Wu, Hao, Wang, Xinzhi, He, Li
Publicado 2023

Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia

por Xie, Zhifu, Zhang, Mei, Song, Qian, Cheng, Long, Zhang, Xinwen, Song, Gaolei, Sun, Xinyu, Gu, Min, Zhou, Chendong, Zhang, Yangming, Zhu, Kexin, Yin, Jianpeng, Chen, Xiaoyan, Li, Jingya, Nan, Fajun
Publicado 2023

Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

por Zhou, Yujun, Tang, Jingshu, Lan, Jiaqi, Zhang, Yong, Wang, Hongyue, Chen, Qiuyu, Kang, Yuying, Sun, Yang, Feng, Xinhong, Wu, Lei, Jin, Hongtao, Chen, Shizhong, Peng, Ying
Publicado 2023

A tactical nanomissile mobilizing antitumor immunity enables neoadjuvant chemo-immunotherapy to minimize postsurgical tumor metastasis and recurrence

por He, Tao, Hu, Mingxing, Zhu, Shunyao, Shen, Meiling, Kou, Xiaorong, Liang, Xiuqi, Li, Lu, Li, Xinchao, Zhang, Miaomiao, Wu, Qinjie, Gong, Changyang
Publicado 2023

Development of fluorine-substituted NH(2)-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability

por Jin, Xin, Wang, Shuai, Zhao, Limin, Huang, Wenjuan, Zhang, Yinxiang, Pannecouque, Christophe, De Clercq, Erik, Meng, Ge, Piao, Huri, Chen, Fener
Publicado 2023

Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammat...

por Fan, Xiaoqing, Mai, Chutian, Zuo, Ling, Huang, Jumin, Xie, Chun, Jiang, Zebo, Li, Runze, Yao, Xiaojun, Fan, Xingxing, Wu, Qibiao, Yan, Peiyu, Liu, Liang, Chen, Jianxin, Xie, Ying, Leung, Elaine Lai-Han
Publicado 2023

Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats

por Meng, Jing, Tian, Jingzhuo, Zhao, Yong, Li, Chunying, Yi, Yan, Zhang, Yushi, Han, Jiayin, Wang, Lianmei, Pan, Chen, Liu, Suyan, Liu, Chenyue, Wang, Fang, Tang, Xuan, Wang, Dunfang, Qin, Shasha, Liang, Aihua
Publicado 2023

Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

por Ruan, Huitong, Li, Yongfang, Wang, Cheng, Jiang, Yixu, Han, Yulong, Li, Yiwei, Zheng, Dandan, Ye, Jing, Chen, Gang, Yang, Guo-yuan, Deng, Lianfu, Guo, Ming, Zhang, Xingcai, Tang, Yaohui, Cui, Wenguo
Publicado 2023

Genomic, transcriptomic, and epigenomic analysis of a medicinal snake, Bungarus multicinctus, to provides insights into the origin of Elapidae neurotoxins

por Xu, Jiang, Guo, Shuai, Yin, Xianmei, Li, Mingqian, Su, He, Liao, Xuejiao, Li, Qiushi, Le, Liang, Chen, Shiyu, Liao, Baosheng, Hu, Haoyu, Lei, Juan, Zhu, Yingjie, Qiu, Xiaohui, Luo, Lu, Chen, Jun, Cheng, Ruiyang, Chang, Zhenzhan, Zhang, Han, Wu, Nicholas Chieh, Guo, Yiming, Hou, Dianyun, Pei, Jin, Gao, Jihai, Hua, Yan, Huang, Zhihai, Chen, Shilin
Publicado 2023