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  1. 68521
    “…Thus, when taken together, these results support the working hypothesis that cell-cycle control architectures are HOT networks and establish the mathematical estimation and subsequent therapeutic exploitation of fragile mechanisms as a novel strategy for anti-cancer lead generation.…”
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    A Test of Highly Optimized Tolerance Reveals Fragile Cell-Cycle Mechanisms Are Molecular Targets in Clinical Cancer Trials
  2. 68522
    “…The functional assignments served as a basis to develop a mathematical model, linking 666 genes (both previously and newly annotated) to metabolic roles. …”
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    Analysis of Aspergillus nidulans metabolism at the genome-scale
  3. 68523
    “…Our results demonstrate that (1) previously reported discordance between DEG lists could simply result from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion with a non-stringent P-value cutoff filtering, the DEG lists become much more reproducible, especially when fewer genes are selected as differentially expressed, as is the case in most microarray studies; and (3) the instability of short DEG lists solely based on P-value ranking is an expected mathematical consequence of the high variability of the t-values; the more stringent the P-value threshold, the less reproducible the DEG list is. …”
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    The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
  4. 68524
    por Goodin, Douglas S.
    Publicado 2009
    “…METHODOLOGY/PRINCIPAL FINDINGS: A mathematical Model for MS pathogenesis is developed, incorporating these environmental and genetic factors into a causal scheme that can explain some of the recent changes in MS-epidemiology (e.g., increasing disease prevalence, a changing sex-ratio, and regional variations in monozygotic twin concordance rates). …”
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    The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis
  5. 68525
    “…The design used was mathematical curve fitting on observed growth response data from children treated with a GH dose of 33 μg/kg/d. …”
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    The first-year growth response to growth hormone treatment predicts the long-term prepubertal growth response in children
  6. 68526
    “…BACKGROUND: Most mathematical models of biochemical pathways consider either signalling events that take place within a single cell in isolation, or an 'average' cell which is considered to be representative of a cell population. …”
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    From pathway to population – a multiscale model of juxtacrine EGFR-MAPK signalling
  7. 68527
    “…BACKGROUND: Until recently, mathematical models of person to person infectious diseases transmission had to make assumptions on transmissions enabled by personal contacts by estimating the so-called WAIFW-matrix. …”
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    Mining social mixing patterns for infectious disease models based on a two-day population survey in Belgium
  8. 68528
    “…Previous attempts to explain these results harnessed additional genes to the system and deployed complex deterministic mathematical models that were only partially successful in explaining the results. …”
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    Stochastic Analysis of the SOS Response in Escherichia coli
  9. 68529
    “…Abnormalities were quantified and grouped by system, then compared and summarized, but the numbers were too small for more complex mathematical analysis. The quantification of physical and laboratory abnormalities allowed at least the creation of a practical clinical boundary, separating probable Morgellons from non-Morgellons patients. …”
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    Morgellons disease, illuminating an undefined illness: a case series
  10. 68530
    “…We also point out the similarities and differences between ICM and MASP algorithms through both mathematically relationships and segmentation results on CT images. …”
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    Automated ventricular systems segmentation in brain CT images by combining low-level segmentation and high-level template matching
  11. 68531
    “…For each response factor, experimental data were fitted mathematically. After data translation to €/Mg dry straw, determining the relative contribution of each response factor, an economic optimization was calculated within the limits of the design variables. …”
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    Optimization of the dilute maleic acid pretreatment of wheat straw
  12. 68532
    “…In hearts pre-treated with the carbonic anhydrase (CA) inhibitor, 6-ethoxyzolamide, the (13)C measurement underestimated the (31)P-measured pH(i) by 0.80 pH units. Mathematical modelling predicted that the validity of measuring pH(i) from the H(13)CO(3)(−)/(13)CO(2) ratio depended on CA activity, and may give an incorrect measure of pH(i) under conditions in which CA was inhibited, such as in acidosis. …”
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    Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a (13)C and (31)P magnetic resonance spectroscopy study
  13. 68533
    “…Oscillations were detected at the single-cell level using real-time microscopy as well as at the population level using high-throughput image analysis. In addition, mathematical modeling of NF-κB dynamics during bacterial infections predicted masking of oscillations on the population level in asynchronous activations, which was experimentally confirmed. …”
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    High-throughput and single-cell imaging of NF-κB oscillations using monoclonal cell lines
  14. 68534
    por Silva, Ariosto S, Gatenby, Robert A
    Publicado 2010
    “…RESULTS: This work confirms the prediction of previous mathematical models and simulations that suggested that administration of chemotherapy with the goal of tumor stabilization instead of eradication would yield better results (longer subject survival) than the use of maximum tolerated doses. …”
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    A theoretical quantitative model for evolution of cancer chemotherapy resistance
  15. 68535
    por Boyko, Ryan H., Marshall, Andrew J.
    Publicado 2010
    “…METHODOLOGY/PRINCIPAL FINDINGS: We used mathematical simulations to model nest building behavior in an orangutan population to compare the quality of the population size estimates produced by two of the commonly used nest count methods, the ‘marked recount method’ and the ‘matrix method.’ …”
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    Using Simulation Models to Evaluate Ape Nest Survey Techniques
  16. 68536
    “…BACKGROUND: Mathematical models of infection that consider targeted interventions are exquisitely dependent on the assumed mixing patterns of the population. …”
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    Comparison of three methods for ascertainment of contact information relevant to respiratory pathogen transmission in encounter networks
  17. 68537
    “…BACKGROUND: It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of resistance in the field is challenging. Mathematical models indicate that drug coverage is the primary determinant of drug pressure and the driving force behind the evolution of drug resistance. …”
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    Drug coverage in treatment of malaria and the consequences for resistance evolution - evidence from the use of sulphadoxine/pyrimethamine
  18. 68538
    “…We now test the relationship between flexibility and robustness, using a mathematical model of the circuit controlling conidiation in the fungus Neurospora crassa. …”
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    Robustness from flexibility in the fungal circadian clock
  19. 68539
    “…Assuming HIV status among individuals contacted but who refused to test (non-response) is missing at random and mortality among non-testers can be related to mortality of those tested a mathematical model was developed. Non-parametric bootstrapping was used to estimate the 95% confidence intervals around the estimates. …”
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    Adjusting HIV Prevalence for Survey Non-Response Using Mortality Rates: An Application of the Method Using Surveillance Data from Rural South Africa
  20. 68540
    por Haney, Seth, Bardwell, Lee, Nie, Qing
    Publicado 2010
    “…RESULTS: We studied the behavior of simple mathematical models of signaling networks composed of two interconnected pathways that share an intermediate component, asking if the two pathways in the network could exhibit both output specificity (preferentially activate their own output) and input fidelity (preferentially respond to their own input). …”
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    Ultrasensitive Responses and Specificity in Cell Signaling
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