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  1. 69061
    “…CE allows one to clearly visualise the evolution of individual genomes and populations through a formal, mathematically-rigorous information space. Overall, CE makes a set of biological predictions, some of which are unique and await functional validation.…”
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    Information compression exploits patterns of genome composition to discriminate populations and highlight regions of evolutionary interest
  2. 69062
    “…Quantitative immunofluorescent approaches have the potential to provide a mathematically continuous measure of HER2. Here we seek to determine whether quantitative measurement of HER2 or phospho-HER2 correlates with likelihood of response to trastuzumab- containing neoadjuvant therapy. …”
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    Quantitative measurements of HER2 and phospho-HER2 expression: correlation with pathologic response to neoadjuvant chemotherapy and trastuzumab
  3. 69063
    “…The overlap between method-specific and common results is considerable, even if the basic mathematical assumptions are very different. The three-fold validated network of life cycle stage characteristics of Plasmodium falciparum could identify a large amount of the known associations from literature in only one study.…”
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    Integrative omics analysis. A study based on Plasmodium falciparum mRNA and protein data
  4. 69064
    “…Assessment of liver pathology may be improved by creating a predictive mathematical model by which AFP levels with other biomarkers.…”
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    Alpha-fetoprotein level as a biomarker of liver fibrosis status: a cross-sectional study of 619 consecutive patients with chronic hepatitis B
  5. 69065
    “…An inertial measurement unit was located near the top of the device measuring its angular position along the frontal and sagittal planes. We used a mathematical model to infer forearm and wrist torque. …”
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    Quantifying forearm and wrist joint power during unconstrained movements in healthy individuals
  6. 69066
    “…RESULTS: A prediction model based on logistic regressions achieved a very good stratification of the population but had the disadvantages of needing mathematical optimization and being difficult to use in daily clinical practice. …”
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    A diagnostic scale for Alzheimer’s disease based on cerebrospinal fluid biomarker profiles
  7. 69067
    “…BACKGROUND: The scale and complexity of genomic data lend themselves to analysis using sophisticated mathematical techniques to yield information that can generate new hypotheses and so guide further experimental investigations. …”
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    Comprehensive analysis of forty yeast microarray datasets reveals a novel subset of genes (APha-RiB) consistently negatively associated with ribosome biogenesis
  8. 69068
    “…A standard biphasic mathematical model was used to compare hepatitis B virus (HBV) DNA decay parameters. …”
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    Early Viral Kinetics with Telbivudine, Tenofovir or Combination of Both in Immunotolerant Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B
  9. 69069
    “…Our comparative analysis identified 1,224 and 2,705 ortholog groups present in all or only some of the ten strains, respectively. Based on mathematical modeling, sequencing of additional L. crispatus isolates would result in the identification of new genes and functions, whereas the conserved core of the ten strains was a good representation of the final L. crispatus core genome, estimated to level at about 1,116 ortholog groups. …”
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    Comparative genomics of Lactobacillus crispatus suggests novel mechanisms for the competitive exclusion of Gardnerella vaginalis
  10. 69070
    “…Conclusion: Deformation maps produced by DIR algorithms must be treated as mathematical approximations of physical tissue deformation that are not self-consistent and may thus be useful only in applications for which they have been specifically validated. …”
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    A Voxel-by-Voxel Comparison of Deformable Vector Fields Obtained by Three Deformable Image Registration Algorithms Applied to 4DCT Lung Studies
  11. 69071
    por Gottlieb, Klaus, Hussain, Fez
    Publicado 2015
    “…The VISA “2 + 1” reading algorithm, based on voting, can translate individual reader scores into a final score in a fashion that is both mathematically sound (by avoiding averaging of ordinal data) and in a manner that is consistent with the scoring task at hand (based on decisions about the presence or absence of features, a subjective classification task). …”
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    Voting for Image Scoring and Assessment (VISA) - theory and application of a 2 + 1 reader algorithm to improve accuracy of imaging endpoints in clinical trials
  12. 69072
    “…Statistical analysis and mathematical modelling used both laboratory results and neuropsychological testing outcomes in order to assess whether ACPH would be acceptable as biomarker for chronic exposure to OPP. …”
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    Assessing biomarkers and neuropsychological outcomes in rural populations exposed to organophosphate pesticides in Chile – study design and protocol
  13. 69073
    “…Identifying infected individuals is particularly difficult in rural settings. We used mathematical modeling to predict the impact of community-based, integrated TB/HIV case finding and additional control strategies on South Africa’s TB/HIV epidemics. …”
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    Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa
  14. 69074
    por Volokin, Den, ReLlez, Lark
    Publicado 2014
    “…We demonstrate that this formula as applied to spherical objects is mathematically incorrect owing to Hölder’s inequality between integrals and leads to biased results such as a significant underestimation of Earth’s ATE. …”
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    On the average temperature of airless spherical bodies and the magnitude of Earth’s atmospheric thermal effect
  15. 69075
    “…Moreover, although it is a common practice to test methods by application to synthetic datasets, the mathematical models used to synthesise such datasets are usually based on approximations which may not always be sufficiently representative of real datasets. …”
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    UNCLES: method for the identification of genes differentially consistently co-expressed in a specific subset of datasets
  16. 69076
    “…In rare bnAb-virus combinations, inhibition for both transmission modes was comparable but no bnAb potently blocked cell-cell transmission across all probed virus strains. Mathematical analysis indicated an increased probability of bnAb resistance mutations to arise in cell-cell rather than free virus spread, further highlighting the need to block this pathway. …”
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    Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent
  17. 69077
    “…METHODS AND FINDINGS: Deterministic mathematical models are described that use only field-measurable input parameters and capture the biological processes that mediate PPF autodissemination. …”
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    Predicting Scenarios for Successful Autodissemination of Pyriproxyfen by Malaria Vectors from Their Resting Sites to Aquatic Habitats; Description and Simulation Analysis of a Field-Parameterizable Model
  18. 69078
    “…METHODS: Thirty participants (18-50y) completed three randomized, counter-balanced walking tasks over a course during: (1) normal walking (control), (2) texting and walking, and (3) texting and walking whilst being cognitively distraction via a standard mathematical test performed while negotiating the obstacle course. …”
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    Gait Pattern Alterations during Walking, Texting and Walking and Texting during Cognitively Distractive Tasks while Negotiating Common Pedestrian Obstacles
  19. 69079
    “…Error associated with mathematical modeling of temporal dynamics of both EEG slow-wave activity and cerebral lactate either did not differ significantly when state scoring was done with automated versus visual scoring, or was reduced with automated state scoring relative to manual classification. …”
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    An automated sleep-state classification algorithm for quantifying sleep timing and sleep-dependent dynamics of electroencephalographic and cerebral metabolic parameters
  20. 69080
    “…BMI, WHR, WHtR, BAI and VAI were computed mathematically. RESULTS: VAI was the most sensitive index in determining DMT2 (AUC 0.72; p < 0.001) in the 2008–2009 cohort and MetS (AUC = 0.84; p < 0.001) in the 2013–2014 cohort. …”
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    Sensitivity of various adiposity indices in identifying cardiometabolic diseases in Arab adults
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