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  1. 69081
    “…Receptor level dynamics and systemic parameters were coupled with multiple neutrophil phenotypes to generate dynamic populations of activated neutrophils which reduce pathogen load, and/or primed neutrophils which cause adverse tissue damage when misdirected. The mathematical model was calibrated using experimental data from baboons administered a two-hour infusion of E coli and followed for a maximum of 28 days. …”
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    A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis
  2. 69082
    “…METHODS: We used a mathematical model of inter- and intra-cellular interactions during liver regeneration to infer key molecular factors underlying the dysregulation of multiple regeneration modes, including delayed, suppressed, and enhanced regeneration. …”
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    Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes
  3. 69083
    por Singh, Brajendra K., Michael, Edwin
    Publicado 2015
    “…BACKGROUND: Mathematical models of parasite transmission can help integrate a large body of information into a consistent framework, which can then be used for gaining mechanistic insights and making predictions. …”
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    Bayesian calibration of simulation models for supporting management of the elimination of the macroparasitic disease, Lymphatic Filariasis
  4. 69084
    por Ashrafuzzaman, Md.
    Publicado 2015
    “…Cell based transport properties have been mathematically addressed. Cell contained cross boundary diffusion of materials has been explained using valid formalisms and related analytical expressions have been developed. …”
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    Phenomenology and energetics of diffusion across cell phase states
  5. 69085
    “…Many endemic areas have not yet achieved optimal control due to logistical, biological as well as technical challenges. We used mathematical modelling to quantify VL transmission dynamics and predict the feasibility of achieving the VL elimination target with current control strategies under varying assumptions about the reservoir of infection in humans. …”
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    Feasibility of eliminating visceral leishmaniasis from the Indian subcontinent: explorations with a set of deterministic age-structured transmission models
  6. 69086
    “…METHODS: Eight virtual patients with stress hyperglycemia were simulated by means of a mathematical model. Each virtual patient had a different combination of insulin resistance and insulin deficiency that defined their unique stress hyperglycemia state; the rate of gluconeogenesis was also doubled. …”
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    Simulation and qualitative analysis of glucose variability, mean glucose, and hypoglycemia after subcutaneous insulin therapy for stress hyperglycemia
  7. 69087
    “…In this work, an attempt has been made to present a derivative-based method for the identification of dose gradient. A mathematically derived reference profile (RP) representing the penumbral region of 6 MV 10 cm × 10 cm field was generated from an error function. …”
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    Derivative based sensitivity analysis of gamma index
  8. 69088
    “…We develop a quantitative single cell-based mathematical model for multi-cellular tumor spheroids (MCTS) of SK-MES-1 cells, a non-small cell lung cancer (NSCLC) cell line, growing under various nutrient conditions: we confront the simulations performed with this model with data on the growth kinetics and spatial labeling patterns for cell proliferation, extracellular matrix (ECM), cell distribution and cell death. …”
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    Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data
  9. 69089
    “…In this report, we develop a mathematical model that describes how molecular processes at individual sites of DNA damage give rise to quantifiable foci. …”
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    DNA double-strand break repair: a theoretical framework and its application
  10. 69090
    “…Such reconstructions are biochemically, genetically, and genomically structured knowledge bases that can be converted into a mathematical format to enable a myriad of computational biological studies. …”
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    Systems biology of the structural proteome
  11. 69091
    “…Exploiting modularity, i.e. using biological parts and interconnecting them to build new and more complex biological circuits is one of the key issues. In this context, mathematical models have been used to generate predictions of the behavior of the designed device. …”
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    Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case
  12. 69092
    “…As such, countries need to be able to choose the most efficient interventions for their respective setting. Mathematical models can be valuable tools to inform rational policy decisions and improve resource allocation, but are often unavailable or inaccessible for LMICs, particularly in TB. …”
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    TIME Impact – a new user-friendly tuberculosis (TB) model to inform TB policy decisions
  13. 69093
    “…For this purpose, a process-based mathematical framework was used to compare soluble sugar accumulation in three fruits: grape, tomato, and peach. …”
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    Inter-Species Comparative Analysis of Components of Soluble Sugar Concentration in Fleshy Fruits
  14. 69094
    “…Qualitative comparative analysis (QCA) is a non-probabilistic method that uses mathematical set theory to study complex phenomena; it has been proposed as a potential method to complement traditional evidence synthesis in reviews of complex interventions to identify key intervention components or implementation features that might explain effectiveness or ineffectiveness. …”
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    Using qualitative comparative analysis in a systematic review of a complex intervention
  15. 69095
    por von Wyl, Viktor, Beck, Konstantin
    Publicado 2014
    “…CONCLUSIONS: Taken together, our mathematical modelling framework helps to gain a better understanding of how demographic changes interact with risk adjustment and how redistribution of funds between age groups can be controlled without inducing further selection incentives. …”
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    Risk adjustment in aging societies
  16. 69096
    “…Disabling the Ca(2+)-clock with 2 μM ryanodine induced bradycardia that was less pronounced in Serca2 KO preparations (9 ± 1% vs. 20 ± 3% in Serca2 FF; P < 0.05), suggesting a disrupted Ca(2+)-clock. Mathematical modeling was used to dissect the effects of membrane- and Ca(2+)-clock components on Serca2 KO mouse heart rate and sinus node action potential. …”
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    Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
  17. 69097
    “…METHODS: We develop a mathematical model for the number of microfilariae in a skin snip and parameterise it using data from Guatemala, Venezuela, Ghana and Cameroon collected before the start of ivermectin treatment programmes. …”
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    Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings
  18. 69098
    por Takiyama, Ken, Shinya, Masahiro
    Publicado 2016
    “…The learning curve for the first experiment could be modeled well using a state space model, a mathematical model that describes the motor leaning process. …”
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    Development of a Portable Motor Learning Laboratory (PoMLab)
  19. 69099
    “…ANALYSIS AND DISCUSSION: Results were analyzed by means of a mathematical model where ATPe kinetics and Vr kinetics were mutually regulated. …”
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    Dynamic Regulation of Cell Volume and Extracellular ATP of Human Erythrocytes
  20. 69100
    “…We first developed mathematical models of VDPV2 emergence and spread. We found that in settings with low routine immunisation coverage, the implementation of a single SIA increases the risk of VDPV2 emergence. …”
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    Preventing Vaccine-Derived Poliovirus Emergence during the Polio Endgame
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