“…Current assays preclude testing this hypothesis experimentally. We developed a mathematical model based on the hypothesis and challenged it with available clinical data. …”
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“…The switch to WHO-recommended dolutegravir (DTG)-based regimens could reduce this threat due to DTG’s high genetic barrier to resistance. We used mathematical modeling to predict the impact of the scale-up of DTG-based ART on NNRTI pretreatment drug resistance (PDR) in South Africa, 2020 to 2040. …”
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“…<k> was found to increase linearly with increasing local pyrene concentration ([Py](loc)), where [Py](loc) had been determined mathematically for the Py(x)-G(N) dendrons. The slope of each straight line changed with the nature of the solvent and represented k(diff), the bimolecular rate constant for PEF. k(diff) depended on the solvent viscosity (η) and the probability (p) for PEF upon encounter between an excited and a ground-state pyrene. …”
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“…Here we start from an existing model of macrophage polarization and extend it to the specific conditions encountered inside a tumour by adding signals, receptors, transcription factors and cytokines that are known to be the key components in establishing the cancer cell-macrophage interaction. Then we use a mathematical Boolean model applied to a gene regulatory network of this biological process to simulate its temporal behaviour and explore scenarios that have not been experimentally tested so far. …”
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“…These features can be used for the generation of mathematical models to improve diagnostics in patients with brain tumors. …”
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“…By incorporating these differences in NPIs among socioeconomic subpopulations into mathematical models of COVID-19 transmission dynamics, our modelling of epidemic outcomes and response to COVID-19 can be improved.…”
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“…During 2009, H1N1 Influenza pandemic, statistical and mathematical methods were used to track how the virus spreads around countries. …”
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“…In this article, we describe an approach which uses a combination of statistical and mathematical methods to forecast the outcome of the trial with respect to its stated goal of reducing the prevalence of infection to below 2%. …”
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“…We estimate the impact of the products on the vectorial capacity of the given Anopheles species using an existing mathematical model. With this methodology, we analysed data from recent semi-field studies in Kenya and Tanzania on the impact of transfluthrin-treated eave ribbons, the odour-baited Suna trap and their combination (push–pull system) on HLC of Anopheles arabiensis in the peridomestic area. …”
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“…We used methods adapted for the Russian-speaking sample: getting socio-demographic information, an interview; The scales of psychological well-being; Attachment style and Interpersonal Guilt Questionnaires (study 1); Psychological Separation Inventory, Purpose-in-Life Test, projective methods (study 2), mathematical statistics. (3) Results: A number of factors and indicators of women’s psycho-emotional health decrease in the situation of role overload have been identified. …”
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“…To be ready for new roles and tasks, medical students and physicians will need to understand the fundamentals of AI and data science, mathematical concepts, and related ethical and medico-legal issues in addition with the standard medical principles. …”
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“…The postfix notation expression stacks are recognised as a platform and programming language independent method to describe, store in computer memory and evaluate general systems of differential and algebraic equations of any size. Each mathematical operation and its operands are described by a specially designed data structure, and every equation is transformed into an array of these structures (a Compute Stack). …”
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“…Furthermore, the network connectivity in gut microbiome was exclusively maintained by rare (low abundance) OTUs, while most abundant OTUs were mainly composed of opportunistic invaders such as Mycoplasma and other genera related to fish pathogens such as Flavobacterium. Finally, the mathematical modelling of community assembly using both non-linear least squares models (NLS) based estimates of migration rates and normalized stochasticity ratios (NST) based beta-diversity distances suggested neutral processes drove by taxonomic drift in host and water communities for almost all treatments. …”
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“…This new index is integrated in a mathematical model, which represents the river as an influence diagram where the nodes are the gauged stations and the arcs are the fluvial reaches among the stations, to identify the river reaches in need of resilience improvement. …”
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“…Methods: We defined an optimization problem as a concise framework of treatment aims and formulated a fitness function for grading sepsis treatments according to their success in accomplishing the pre-defined aims. We developed a mathematical model for the interactions between the pathogen, the cellular immune system and the drugs, whose simulations under diverse combined meropenem and nivolumab schedules, and calculation of the fitness function for each schedule served to plot the fitness landscapes for each set of treatments and personal patient parameters. …”
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“…This study aims at investigating anti-tumor activity of AZD4635 alone and in combination with an anti-PD-L1-specific antibody (anti-PD-L1 mAb) across various TME conditions and at identifying, via mathematical quantitative modeling, a therapeutic combination strategy to further improve treatment efficacy. …”
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“…In understanding the optimum value and significant effect of factors on the fire retardant and moisture absorption properties of the binary blended geopolymer coating composite, the use of statistical analysis and regression coefficient model (mathematical model) was considered essential. The objectives of this study are to identify the significant effect of factors on moisture absorption and fire retardant properties, to determine the optimum composition, and to study the microstructure of the rice husk ash/silicone rubber (RHA/SiR)-based binary blended geopolymer coating composite. …”
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“…We report the design optimization of a hybrid face robot, which combines digital facial expressions based on mathematical affect space mapping with static 3D facial features. …”
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“…METHODS: We used a mathematical model to analyze the expected effectiveness of symptom monitoring, testing, and quarantine under different estimates of the infectious period, test-positivity relative to time of infection, and test sensitivity to reduce the risk of transmission from infected travelers during and after travel. …”
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“…The study therefore recommends GEP as more rational and a better alternative for precise water quality monitoring of surface water bodies by producing simplified mathematical expressions.…”
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