“…CONCLUSIONS: Developed algorithms are mathematically proved, which justifies the following statements. …”
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“…Affinity profiling by the 293-Affinofile assay and mathematical modeling using VERSA (Viral Entry Receptor Sensitivity Analysis) metrics revealed that 17-Res and 24-Res Envs engaged MVC-bound CCR5 inefficiently or very efficiently, respectively. …”
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“…RESULTS: We have assembled a high-throughput software platform for plant cell wall profiling that uses spectral deconvolution by Fast Maximum Likelihood Reconstruction (FMLR) to construct a mathematical model of the signals present in a set of related NMR spectra. …”
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“…RESULTS: The prototype of software system, which includes a subsystem of the multiagent simulation and specialized statistical and mathematical sub-system which can process the simulation results and perform a conditional optimization of the selected objective functions (morbidity, the effectiveness of specific preventive and control activities and their price, measure of reducing the socio-economic impact of HBV infection, etc.) have been developed. …”
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“…Although the technical explanation of the differences remains unclear and needs further exploration, we found that the evaluation of this type of remote sensing tools should not only be focused at the level of assumptions (i.e. physical or mathematical aspects of image processing), but also at the level of results (i.e. contrasting observed patterns with independent proofs of change). …”
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“…BACKGROUND: Efforts to develop malaria vaccines show promise. Mathematical model-based estimates of the potential demand, public health impact, and cost and financing requirements can be used to inform investment and adoption decisions by vaccine developers and policymakers on the use of malaria vaccines as complements to existing interventions. …”
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“…We define ‘PA disparity’ as the non-negative value of the difference (in mathematical terms the absolute difference) between objective and self-reported physical activity energy expenditure (PAEE in kJ · kg(-1) · day(-1)). …”
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“…The comprehensive understanding of the molecular mechanism of apoptotic signaling allows for development of mathematical models, aiming to elucidate dynamical and systems properties of apoptotic signaling networks. …”
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“…In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT) observations, a relatively simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO) for the OGTT, which coherently incorporates commonly accepted physiological assumptions (incretin effect and saturating glucose-driven insulin secretion) has been developed. …”
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“…Compared to these three ‘baseline conditions’, statistically significant differences ([Image: see text]) were: [Image: see text]A-Tm[Image: see text] – actin sliding velocity increased 1.12-fold, [Image: see text]A-Tm[Image: see text] – motile fraction decreased to 0.96-fold, stop time elevated 1.6-fold, [Image: see text]A-Tm[Image: see text] – run time elevated 1.7-fold. We constructed a mathematical model, simulated actin sliding data, and adjusted the kinetic parameters so as to mimic the experimentally observed differences: [Image: see text]A-Tm[Image: see text] – myosin binding to actin, the main, and the secondary myosin power stroke are accelerated, [Image: see text]A-Tm[Image: see text] – mechanical coupling between myosins is stronger, [Image: see text]A-Tm[Image: see text] – the secondary power stroke is decelerated and mechanical coupling between myosins is weaker. …”
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“…Here, we employ a deterministic mathematical model describing various Ca(2+) signalling pathways under voltage clamp (VC) conditions, to better understand the important role of calmodulin (CaM) in modulating the key control variables Ca(2+)/calmodulin-dependent protein kinase-II (CaMKII), calcineurin (CaN), and cyclic adenosine monophosphate (cAMP) as they affect various intracellular targets. …”
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“…BACKGROUND: When mathematical modelling is applied to many different application areas, a common task is the estimation of states and parameters based on measurements. …”
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“…Results measured after a 12-week remediation program aimed at increasing the activity of the hypothesized underactive right hemisphere function, yielded significant improvement of greater than 2 years in grade level in all domains except in mathematical reasoning. The treated group also displayed a significant improvement in behavior with a reduction in Brown scale behavioral scores. …”
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“…CONCLUSIONS: SNPs within the CCR5 gene should be considered as an important factor used in combination with other host gene SNPs when developing a mathematical model for anticipating response to HCV therapy.…”
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“…A dedicated method for the analysis and processing of images involving median filtering, mathematical morphology, binarization, polynomial approximation and the active contour method has been proposed. …”
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“…BACKGROUND: When modelling infectious diseases, accurately capturing the pattern of dissemination through space is key to providing optimal recommendations for control. Mathematical models of disease spread in livestock, such as for foot-and-mouth disease (FMD), have done this by incorporating a transmission kernel which describes the decay in transmission rate with increasing Euclidean distance from an infected premises (IP). …”
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“…METHOD: A spatially-explicit, individual-based mathematical model that accounts for the spread of dengue infection as a result of human movement and mosquito dispersion is presented. …”
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“…However, because both SVV and PPV were obtained from pulse pressure analysis, a mathematical coupling factor could not be excluded. We therefore designed this study to confirm whether Ea(dyn), obtained from two independent signals, allows the prediction of arterial pressure response to VE in fluid-responsive patients. …”
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“…RESULTS: It has been shown in a large number of studies that 3-dimensional topology of a protein structure is well captured by a graph, making it possible to analyze a complex protein structure as a mathematical entity. In this study we show that eigen spectra profile of a protein structure graph exhibits a unique repetitive profile for contiguous repeating units enabling the detection of the repeat region and the repeat type. …”
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“…Although we can reproduce biological systems by incorporating such findings and describing their dynamics as mathematical equations, simulation results can be inconsistent with data from biological observations if there are inaccurate or unknown parts in the constructed system. …”
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