“…MeMeMe recruiting experience, highlighting strengths, limitations encountered and results is reported. …”
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“…We are conducting a Phase III trial on persons with metabolic syndrome to test the hypothesis that comprehensive lifestyle changes and/or metformin treatment prevents age-related chronic diseases (the MeMeMe trial, EudraCT number: 2012-005427-32, also registered on ClinicalTrials.gov [NCT02960711]). …”
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“…OBJECTIVE: This paper describes a novel software created specifically for the management of a randomized trial of diet and metformin in people with metabolic syndrome (the Me.Me.Me. trial). METHODS: Me.Me.Me. is an ongoing phase III randomized controlled trial in healthy people with metabolic syndrome to test the hypothesis that comprehensive lifestyle changes and/or metformin can prevent age-related chronic non-communicable diseases. …”
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“…[Image: see text] Five neutral bis(μ-phenoxido)dicopper(II) complexes, [Cu(2)(L(Me,Me,Me))(2)] (1), [Cu(2)(L(Me,Me,Et))(2)]·CH(2)Cl(2) (2), [Cu(2)(L(i-Pr,i-Pr,i-Pr))(2)]·2H(2)O (3), [Cu(2)(L(t-Bu,Me,i-Pr))(2)] (4), and [Cu(2)(L(t-Bu,t-Bu,i-Pr))(2)]·H(2)O (5) have been synthesized and characterized by single-crystal X-ray diffraction analyses, magnetic studies, and density functional theory (DFT) calculations, in which the ligands [H(2)L(Me,Me,Me) = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N′,N′-dimethylethylene-1,2-diamine, H(2)L(Me,Me,Et) = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N′,N′-dimethylethylene-1,2-diamine, H(2)L(i-Pr,i-Pr,i-Pr) = N,N-bis(2-hydroxy-3,5-diisopropylbenzyl)-N′,N′-diisopropylethylene-1,2-diamine, H(2)L(t-Bu,Me,i-Pr) = N,N-bis(2-hydroxy-3-tert-butyl-5-methylbenzyl)-N′,N′-diisopropylethylene-1,2-diamine, and H(2)L(t-Bu,t-Bu,i-Pr) = N,N-bis(2-hydroxy-3,5-di-tert-butylbenzyl)-N′,N′-diisopropylethylene-1,2-diamine] contain the same [O,N,N,O]-donor atoms combination but differ in substituents at phenol rings and at an amino nitrogen atom. …”
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