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“…The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues. …”
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“…For the first time a HEL in high luminosity configuration is simulated in the HL LHC using the recently updated MERLIN 5 accelerator libraries. The effects on the LHC beam halo are observed for various HEL operation modes.…”
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“…This review explores possible mechanisms by which the neurofibromatosis type-2 tumour suppressor Merlin regulates contact-dependent inhibition of proliferation. …”
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“…Here we apply a phylogenetic approach to the Hippo pathway and predict that two of its signal transducers, Salvador and Merlin/Nf2 (also a tumor suppressor) are regulated by monoubiquitylation. …”
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“…The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4(DCAF1). …”
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“…The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. …”
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“…In the present paper, a mixed hemosporidia infection by Leucocytozoon californicus and Haemoproteus sp. in an adult male merlin (Falco columbarius) which died during hospitalisation is reported, indicating, for the first time, a newly described avian host species. …”
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“…The transposon superfamily Merlin was originally found mainly in animal genomes. …”
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“…The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. …”
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“…Merlin has been shown to dimerize, but the regulation and function Merlin dimerization is not clear. …”
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“…HELs can be used as soft scraper devices, and may operate close to the beam core without undergoing damage [2]. We use the Merlin C++ accelerator libraries [3] to implement a HEL and examine the effect on the beam halo for various test scenarios.…”
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“…Merlin++ is a C++ charged-particle tracking library developed for the simulation and analysis of complex beam dynamics within high energy particle accelerators. …”
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“…The accelerator physics code MERLIN has been extended in many areas to make detailed studies of the LHC collima- tion system and calculate loss maps from beam halo losses. …”
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“…Merlin, encoded by the NF2 gene, is a tumor suppressor that exerts its function via inhibiting mitogenic receptors at the plasma membrane. …”
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“…Although the mechanisms that balance self-renewal and differentiation of a stem cell lineage have been extensively studied, it remains poorly understood how tissues that contain multiple stem cell lineages maintain balanced proliferation among distinct lineages: when stem cells of a particular lineage proliferate, how do the other lineages respond to maintain the correct ratio of cells among linages? Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis. …”
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“…Together, this study unveils the role of intercellular interaction and intracellular Merlin-YAP signalling in dictating ferroptotic death; it also suggests that malignant mutations in Merlin-YAP signalling can serve as biomarkers predicting cancer cell responsiveness to future ferroptosis-inducing therapies.…”
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“…Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. …”
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“…Tumour-derived inactivating mutations in both Merlin and the CDC73 PAFC subunit mutually disrupt their interaction and growth suppression by Merlin requires CDC73. …”
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