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Mostrando 61 - 80 Resultados de 3,158 Para Buscar '"Merlín"', tiempo de consulta: 0.65s Limitar resultados
  1. 61
    “…Genome-scale metabolic models have been recognised as useful tools for better understanding living organisms’ metabolism. merlin (https://www.merlin-sysbio.org/) is an open-source and user-friendly resource that hastens the models’ reconstruction process, conjugating manual and automatic procedures, while leveraging the user's expertise with a curation-oriented graphical interface. …”
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    merlin, an improved framework for the reconstruction of high-quality genome-scale metabolic models
  2. 62
    “…Furthermore, Neogenin protein level is associated with good prognosis and correlates with Merlin status in CRC and Glioma. Collectively, our results define Neogenin as a tumor suppressor in CRC and Glioma that acts by restricting oncogenic signaling by the Merlin-YAP pathway, and suggest Neogenin as a candidate therapeutic agent for CRC and Glioma.…”
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    Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling
  3. 63
    por Wittrock, Merlin C.
    Publicado 1986
    Libro
    Handbook of research on teaching Merlin Wittrock
  4. 64
    “…Meningiomas are the most common primary intracranial tumors and are associated with inactivation of the tumor suppressor NF2/Merlin, but one-third of meningiomas retain Merlin expression and typically have favorable clinical outcomes. …”
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    Merlin(S13) phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features
  5. 65
    “…Merlin low‐risk patients are recommended to undergo wide local excision (WLE) of the primary tumor, whereas Merlin high‐risk patients are recommended to undergo both SLNB and WLE. …”
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    Cost evaluation of the Merlin assay for predicting melanoma sentinel lymph node biopsy metastasis
  6. 66
    “…Hepatocyte growth factor receptor tyrosine kinase substrate (HRS) is an endosomal protein required for trafficking receptor tyrosine kinases from the early endosome to the lysosome. HRS interacts with Merlin, the Neurofibromatosis 2 (NF2) gene product, and this interaction may be important for Merlin’s tumor suppressor activity. …”
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    Evolution and Origin of HRS, a Protein Interacting with Merlin, the Neurofibromatosis 2 Gene Product
  7. 67
    “…Loss of the Merlin tumour suppressor causes abnormal de-differentiation and proliferation of Schwann cells and formation of schwannoma tumours in patients with neurofibromatosis type 2. …”
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    Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells
  8. 68
    “…The mechanism that controls total cell number is known as contact inhibition of growth and it depends on the NF2/Merlin pathway. Negative regulation of this pathway by deleterious mutations or by oncogenes results in cell transformation and tumor progression. …”
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    CD43 Promotes Cells Transformation by Preventing Merlin-Mediated Contact Inhibition of Growth
  9. 69
    “…Yet despite increasing knowledge of merlin function, there are no NF2 drug therapies. …”
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    Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis
  10. 70
    por Tuttle, Merlin D.
    Publicado 1988
    Libro
    America's neighborhood bats
  11. 71
    Publicado 1982
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    Event display from a very preliminary run of UA1 (seen from MERLIN)
  12. 72
    Publicado 1982
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    Event display from a very preliminary run of UA1 (seen from MERLIN)
  13. 73
    “…[Image: see text] The ERM (ezrin, radixin, and moesin) family of proteins and the related protein merlin participate in scaffolding and signaling events at the cell cortex. …”
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    Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin
  14. 74
    “…BACKGROUND: Merlin, the product of the Neurofibromatosis type 2 (NF2) tumor suppressor gene, belongs to the ezrin-radixin-moesin (ERM) subgroup of the protein 4.1 superfamily, which links cell surface glycoproteins to the actin cytoskeleton. …”
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    Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene
  15. 75
    por Hughes, Sarah C., Fehon, Richard G.
    Publicado 2006
    “…Merlin and Moesin are closely related members of the 4.1 Ezrin/Radixin/Moesin domain superfamily implicated in regulating proliferation and epithelial integrity, respectively. …”
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    Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase
  16. 76
    “…Merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene, is a member of the protein 4.1 superfamily that is most closely related to ezrin, radixin, and moesin (ERM). …”
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    Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization
  17. 77
    “…PAK's ability to release human umbilical vein endothelial cells from contact inhibition is blocked by an unphosphorylatable form of its target Merlin, suggesting that PAK promotes mitogenesis by phosphorylating, and thus inactivating, Merlin. …”
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    Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
  18. 78
    “…The Neurofibromatosis 2 (NF2) gene product merlin is a tumour suppressor, which in addition to inhibiting cell proliferation regulates cell morphology. …”
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    Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity
  19. 79
    “…This review highlights cancers in which somatic NF2 mutations have been found, the cell signaling pathways involving NF2/merlin, current clinical trials treating neurofibromatosis 2 patients, and preclinical findings that promise to lead to new targeted therapies for both cancers harboring NF2 mutations and neurofibromatosis 2 patients.…”
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    NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations
  20. 80
    “…The tumour suppressor Merlin, encoded by the gene NF2, is frequently mutated in the autosomal dominant disorder neurofibromatosis type II, characterised primarily by the development of schwannoma and other glial cell tumours. …”
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    Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation
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