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  1. 3481
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    Epidemiology of gastrointestinal symptoms in young and middle-aged Swiss adults: prevalences and comorbidities in a longitudinal population cohort over 28 years
  2. 3482
    “…[Purpose] The purpose of this study is to investigate the effects of circuit exercise on obesity index, appetite regulating hormones and insulin resistance in middle-aged obese women. [Subjects and Methods] The subjects of this study were 26 obese middle-aged women who were selected among participants in exercise class at K Region Health Promotion Center in South Korea and were randomly assigned to the exercise group (n=13; age 50.15 ± 3.82, % body fat 38.79 ± 3.28) and the control group (n=13; age 49.84 ± 2.96, % body fat 37.46 ± 2.51). …”
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    Effects of 12-week circuit exercise program on obesity index, appetite regulating hormones, and insulin resistance in middle-aged obese females
  3. 3483
    “…The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). …”
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    Different Associations of Trunk and Lower-Body Fat Mass Distribution with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and Women
  4. 3484
    “…BACKGROUND: Late middle age (LMA), is a watershed between youth and old age, with unique physical and social changes and declines in vitality, but a desire to remain active despite increasing comorbidity. …”
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    Injury patterns and outcomes in late middle age (55–65): The intersecting comorbidity with high-risk activity – A retrospective cohort study
  5. 3485
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    Author Correction: Prevalence and risk factors associated with stroke in middle-aged and older Chinese: A community-based cross-sectional study
  6. 3486
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    Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice
  7. 3487
    “…CONCLUSIONS: In a cohort of middle-aged women in China, anthropometric indices of obesity were predictive of the development of hypertension during a two-year follow-up period.…”
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    Anthropometric Indices Predict the Development of Hypertension in Normotensive and Pre-Hypertensive Middle-Aged Women in Tianjin, China: A Prospective Cohort Study
  8. 3488
    por Oshio, Takashi, Kan, Mari
    Publicado 2018
    “…We examined how their parents’ need for care affects middle-aged women’s lifestyle and psychological distress, considering the potential simultaneity of decisions on caregiving and living adjustments. …”
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    Impact of parents’ need for care on middle-aged women’s lifestyle and psychological distress: evidence from a nationwide longitudinal survey in Japan
  9. 3489
    “…Differences in PTENP1 methylation rates between normal endometrium in young (4%) and middle-aged and elderly (58%) females were significant (p < 0.001). …”
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    The PTENP1 Pseudogene, Unlike the PTEN Gene, Is Methylated in Normal Endometrium, As Well As in Endometrial Hyperplasias and Carcinomas in Middle-Aged and Elderly Females
  10. 3490
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    Dietary, environmental, and genetic risk factors of Extensive Macular Atrophy with Pseudodrusen, a severe bilateral macular atrophy of middle-aged patients
  11. 3491
    “…In this study, we sought to evaluate the impact of six diets, with various EAA/NEAA blends, on body composition and the risk of developing tissue wasting in late middle-aged male mice. Methods: Six groups of late middle-aged male mice were fed for 35 days with iso-nutrients, iso-caloric, and iso-nitrogenous special diets containing different EAA/NEAA ratios ranging from 100/0% to 0/100%. …”
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    Body Weight Loss and Tissue Wasting in Late Middle-Aged Mice on Slightly Imbalanced Essential/Non-essential Amino Acids Diet
  12. 3492
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    Potential common factors associated with predisposition to common cold in middle-aged and elderly Japanese: A community-based cross-sectional study
  13. 3493
    “…Objective: This study investigated the relationship between occupations and health status to obtain an overall understanding of a cohort of Japanese middle-aged women, including unemployed women, who comprised approximately 30% of the sample. …”
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    Agricultural workers in a cohort of middle-aged Japanese women showed better health status than did women with other occupations
  14. 3494
    “…In this study, we developed a new abbreviated version of AUDIT called the Screening Tool for At-risk Drinking (STAD) for young and middle-aged adults, consisting of two questions that reflect the structure of the AUDIT questionnaire using data from the Korea National Health and Nutrition Examination Survey (KNHANES). …”
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    Screening Test for At-Risk Drinking: Development of New Abbreviated Version of Alcohol Use Disorder Identification Test for Young and Middle-Aged Adults
  15. 3495
    “…However, evidence of neuroplasticity notwithstanding, there are few scientifically rigorous, ecologically relevant brain training studies focused on building cognitive reserve in middle age to protect against cognitive decline. This pilot study will examine the ability of virtual reality (VR) cognitive training to improve cognition and cerebral blood flow (CBF) in middle-aged individuals at high AD risk due to parental history. …”
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    Virtual reality-based cognitive-motor training for middle-aged adults at high Alzheimer's disease risk: A randomized controlled trial
  16. 3496
    “…CONCLUSIONS: This is the first study to assess the association of different movement behaviours with lung function among middle-aged and older adults without a respiratory disease. …”
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    Movement behaviours are associated with lung function in middle-aged and older adults: a cross-sectional analysis of the Canadian longitudinal study on aging
  17. 3497
    por Alvarado-Esquivel, Cosme
    Publicado 2018
    “…BACKGROUND: Very little is known about suicide attempts in middle-aged women in Mexico. The aims of this study were to determine: 1) the prevalence of suicidal ideation and suicide attempts in middle-aged women in Durango City, Mexico; and 2) the suicide attempt prevalence association with the sociodemographic, clinical, and behavioral characteristics of the women studied. …”
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    Suicidal Ideation and Suicide Attempts in Middle-Aged Women Attending a Primary Care Center: A Cross-Sectional Study in Mexico
  18. 3498
    “…BACKGROUND: Falls pose major health problems to the middle-aged and older adults and may potentially lead to various levels of injuries. …”
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    Sleep duration and sleep disturbances in association with falls among the middle-aged and older adults in China: a population-based nationwide study
  19. 3499
    “…The present study aimed to assess the relationship between social engagement and diabetes incidence in a middle‐aged Japanese population. MATERIALS AND METHODS: We analyzed data on 31,615 people aged 50–59 years from a prospective national survey carried out in Japan from 2005 to 2013. …”
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    Relationship between social engagement and diabetes incidence in a middle‐aged population: Results from a longitudinal nationwide survey in Japan
  20. 3500
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    Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
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