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  1. 3961
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    Correction to: Multi‑modality biomarkers in the early prediction of ischaemic heart disease in middle‑aged men during a 21‑year follow‑up
  2. 3962
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    External validity of phase III trials on vaccines against SARS-CoV-2 to a middle-aged and elderly Western European population
  3. 3963
    “…CONCLUSION: This is the first demonstration that there are critical sex-specific differences during NASH development in middle-aged mice regarding inflammation, fibrosis, and cholesterol metabolism and that changes in PCSK9 and IL-1β are likely important contributors to sex-specific changes during the transition to NASH.…”
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    Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice
  4. 3964
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    Correction to: An unusual tracheal foreign body in a middle-aged male with a 15-year history of coal use: a case report
  5. 3965
    “…This study aimed to assess the effects of hypertriglyceridemic-waist (HTW) and its dynamic transitions on incident T2DM among middle-aged and older Chinese. Data were extracted from the China Health and Retirement Longitudinal Study (CHARLS). …”
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    Transition of Hypertriglyceridemic-Waist Phenotypes and the Risk of Type 2 Diabetes Mellitus among Middle-Aged and Older Chinese: A National Cohort Study
  6. 3966
    “…This study examines the leading research criteria for traumatic encephalopathy syndrome (TES) in middle-aged men in the general population. Method: Participants were 409 men between the ages of 35 and 55 recruited through an online crowdsourcing platform. …”
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    Examining the Research Criteria for Traumatic Encephalopathy Syndrome in Middle-Aged Men From the General Population Who Played Contact Sports in High School
  7. 3967
    “…This study aimed to investigate the relationship between 25-(OH) D levels and blood pressure (BP), blood lipids, and arterial elasticity in middle-aged and elderly cadres in China. In this retrospective study, we included 401 civil servants and cadres aged >42 years who underwent medical examinations at Guiyang Municipal First People's Hospital, China in 2018. …”
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    Correlation between 25-hydroxyvitamin D level and arterial elasticity in middle-aged and elderly cadres in Guiyang, China: A retrospective observational study
  8. 3968
    “…Conclusion: This systematic review highlights the benefits of different types of physical training interventions on autonomic function and health parameters in young and middle-aged, healthy adults. In conclusion, higher training intensities and frequencies are more likely to improve HRV. …”
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    Effects of Different Training Interventions on Heart Rate Variability and Cardiovascular Health and Risk Factors in Young and Middle-Aged Adults: A Systematic Review
  9. 3969
    por Kwak, Jung Hyun, Choi, Yoon-Hyeong
    Publicado 2021
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    Sex and body mass index dependent associations between serum 25-hydroxyvitamin D and pulse pressure in middle-aged and older US adults
  10. 3970
    “…A POCD model was developed in middle-aged (MA) rats by inducing a tibia fracture via orthopaedic surgery. …”
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    Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats
  11. 3971
    “…BACKGROUND: Literature shows that middle-aged and older adults sometimes experience a wish to die. …”
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    Current wishes to die; characteristics of middle-aged and older Dutch adults who are ready to give up on life: a cross-sectional study
  12. 3972
    “…Methods: A total of 8,289 community-dwelling middle-aged and elderly population from wave 2011, wave 2013, and wave 2015 of the China Health and Retirement Longitudinal Study (CHARLS) were included. …”
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    Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index
  13. 3973
    por Ge, Beihai, Chen, Hao, Liao, Xianhui
    Publicado 2021
    “…OBJECTIVES: This study aims to explore the effect and safety of mind-body exercise intervention on the blood pressure in middle-aged and elderly patients with hypertension through meta-analysis. …”
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    The effect of mind-body exercise on blood pressure in middle-aged and elderly patients with hypertension: A protocol for a systematic review and meta-analysis
  14. 3974
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    Critical role of cardiac magnetic resonance in the diagnosis of left-dominant arrhythmogenic cardiomyopathy: A paradigmatic case in a recreational middle-aged athlete
  15. 3975
    “…At baseline, the subjects were middle-aged (mean age, 47.6 years) and overweight (mean BMI, 28.0 kg/m(2)), and the majority of them (51.2%) had a diagnosis of kOA grade 1. …”
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    Risk Assessment of the Progression of Early Knee Osteoarthritis by Collagen Neoepitope C2C: A Longitudinal Study of an Estonian Middle-Aged Cohort
  16. 3976
    “…Background: This study aimed to evaluate the clinical efficacy of Yun-type optimized pelvic floor training therapy for middle-aged women with severe overactive bladder (OAB). …”
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    Efficacy of Yun-Type Optimized Pelvic Floor Training Therapy for Middle-Aged Women With Severe Overactive Bladder: A Randomized Clinical Trial
  17. 3977
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    Trajectories of middle-aged and elderly people’s chronic diseases Disability Adjusted Life Years (DALYs): cohort, socio-economic status and gender disparities
  18. 3978
    “…CASE REPORT: Herein, we present a case of stroke with large vessel occlusion in a middle-aged man, who recently recovered from severe SARS-CoV-2 infection. …”
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    Large Vessel Occlusion Causing Cerebral Ischemic Stroke in Previously Healthy Middle-Aged Recently Recovered from Severe COVID-19 Infection
  19. 3979
    “…Methods: Participants were selected based on a multicenter prospective study on middle-aged and older adults in China. Global cognitive function was evaluated by the Mini-Mental State Examination (MMSE). …”
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    The Effect and Mechanism of Cholesterol and Vitamin B(12) on Multi-Domain Cognitive Function: A Prospective Study on Chinese Middle-Aged and Older Adults
  20. 3980
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    Frequent, Short Physical Activity Breaks Reduce Prefrontal Cortex Activation but Preserve Working Memory in Middle-Aged Adults: ABBaH Study
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