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  1. 4321
    “…Conclusions: Plasma vitamin C, categorized as suboptimal and sufficient, was positively associated with the lumbar spine BMD in young and early middle-aged men. A well-designed cohort study is needed to confirm the findings.…”
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    Suboptimal Plasma Vitamin C Is Associated with Lower Bone Mineral Density in Young and Early Middle-Aged Men: A Retrospective Cross-Sectional Study
  2. 4322
    “…BACKGROUND: Middle-aged (45-59 years old) patients with major depressive disorder (MDD) have a predilection for dementia and cognitive disorders (CDs); however, the characteristics and mechanisms of CDs in these patients remain unclear. …”
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    Variation in Thyroid-Stimulating Hormone and Cognitive Disorders in Unmedicated Middle-Aged Patients with Major Depressive Disorder: A Proton Magnetic Resonance Spectroscopy Study
  3. 4323
    “…The identified subgroups of middle-aged and elderly residents who live in rural areas with <6 h of sleep and those who live in urban areas may benefit more from the social engagement than the whole participants.…”
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    The association between social engagement and depressive symptoms in middle-aged and elderly Chinese: A longitudinal subgroup identification analysis under causal inference frame
  4. 4324
    “…The aim of this study was to investigate diet-related knowledge, attitudes, and behaviors, and the socio-demographic determinants of these, among young and middle-aged Chinese individuals with high-normal BP. …”
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    Diet-related knowledge, attitudes, and behaviors among young and middle-aged individuals with high-normal blood pressure: A cross-sectional study in China
  5. 4325
    “…Our findings indicated that leucine supplementation in middle-aged mice improved aging-induced vascular remodeling and dysfunction.…”
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    Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis
  6. 4326
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    Comment on: “Effects of resistance training intensity on muscle quantity/quality in middle‐aged and older people: a randomized controlled trial” by Otsuka et al.
  7. 4327
    “…METHODS: Cognitively healthy middle-aged adults (aged 40–59; mean 51.2 years) underwent 3T MRI (n = 630) as part of the PREVENT-Dementia study. …”
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    Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study
  8. 4328
    “…We hypothesised that health effects of the pandemic on middle-aged people might be different depending on SEP and changes in employment. …”
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    Pre-pandemic socio-economic status and changes in employment during the first lockdown (2020) on the health of middle-aged people in England: a longitudinal study
  9. 4329
    “…Medical expenses, especially among middle-aged and elderly people, have increased in China over recent decades. …”
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    Identifying Characteristics Associated with the Concentration and Persistence of Medical Expenses among Middle-Aged and Elderly Adults: Findings from the China Health and Retirement Longitudinal Survey
  10. 4330
    “…The association of Japanese and Mediterranean dietary patterns with muscle weakness in middle-aged and older Japanese individuals is unclear. …”
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    Association of Japanese and Mediterranean Dietary Patterns with Muscle Weakness in Japanese Community-Dwelling Middle-Aged and Older Adults: Post Hoc Cross-Sectional Analysis
  11. 4331
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    Effects of motor-cognitive interaction based on dual-task gait analysis recognition in middle age to aging people with normal cognition and mild cognitive impairment
  12. 4332
    “…The present study aimed to investigate the main determinants of body composition, blood glucose and lipids concentrations between middle-aged sedentary individuals (Sed) and well-trained endurance athletes (Run), both following an unhealthy high-fat diet. …”
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    Body Composition, Fasting Blood Glucose and Lipidemic Indices Are Not Primarily Determined by the Nutritional Intake of Middle-Aged Endurance Trained Men—Another “Athletes’ Paradox”?
  13. 4333
    “…The results showed that middle-aged and older women were more likely to suffer from depression than men, and married middle-aged and older people were less likely to be depressed than those who were separated or divorced, widowed and never married. …”
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    The relationship between gender, marital status and depression among Chinese middle-aged and older people: Mediation by subjective well-being and moderation by degree of digitization
  14. 4334
    “…Our findings suggest that prediabetes and diabetes in middle‐aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life.…”
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    Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90
  15. 4335
    “…In this study we used middle-aged ovariectomized mice to explore the effect of concomitant estrogen deficiency with chronological aging on key aspects of cardiometabolic health and energy expenditure. …”
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    PMON210 Ovariectomy of Middle-Aged Female Mice Leads to Decreased Fat Oxidation and Energy Expenditure Accompanied by Weight Gain and Dysregulated Blood Glucose
  16. 4336
    “…BACKGROUND: Cardiovascular risk factors are frequently associated with lowered cognitive performance among elderly people, but rarely among middle-aged adults. OBJECTIVES: To investigate associations between cardiovascular risk factors (age, physical inactivity, smoking, alcohol use, hypertension and diabetes) and lower cognitive performance among middle-aged (45-64 years) Brazilian adults. …”
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    Diabetes and hypertension are associated with lowered cognitive performance among middle-aged Brazilian adults: cross-sectional analyses nested in the longitudinal Pró-Saúde study
  17. 4337
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    Asymptomatic aggressive angiomyxoma with a two-year follow up in a middle-aged healthy male: A case report and brief review of literature
  18. 4338
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    Relations of postural change in blood pressure with hypertension-mediated organ damage in middle-aged adults of the Framingham heart study: A cross-sectional study
  19. 4339
    “…Logistic regression was used to determine the different characteristics of middle-aged and older adults with a high probability of incurring CHE. …”
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    Degree of protection provided by poverty alleviation policies for the middle-aged and older in China: evaluation of effectiveness of medical insurance system tools and vulnerable target recognition
  20. 4340
    “…In this study, we aimed to compare the reoperation rates for different methodologies of internal fixation for femoral neck fractures in young and middle-aged population. MATERIALS AND METHODS: This a retrospective study. …”
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    Reoperation rate and implants’ position variation features of displaced femoral neck fractures with sliding compression or length-stable fixation in young and middle-aged population
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