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  1. 4721
    “…Tissue specimens were derived from middle-aged (47–62 years) vs. aged (76–82 years) individuals and potential changes in the protein expression profiles were compared between these two age groups by a comprehensive gel electrophoresis-based survey. …”
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    Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle
  2. 4722
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    Trends in Population Blood Pressure and Prevalence, Awareness, Treatment, and Control of Hypertension among Middle-Aged and Older Adults in a Rural Area of Northwest China from 1982 to 2010
  3. 4723
    “…CONCLUSIONS: Poor cognitive performance is associated with adiposity and hyperglycemia in healthy middle-aged people.…”
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    Relationship Between Markers of Insulin Resistance, Markers of Adiposity, HbA(1c), and Cognitive Functions in a Middle-Aged Population–Based Sample: the MONA LISA Study
  4. 4724
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    The Effect of Age and NT-proBNP on the Association of Central Obesity with 6-Years Cardiovascular Mortality of Middle-Aged and Elderly Diabetic People: The Population-Based Casale Monferrato Study
  5. 4725
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    Erratum to “Montreal Cognitive Assessment Is Superior to Standardized Mini-Mental Status Exam in Detecting Mild Cognitive Impairment in the Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus”
  6. 4726
    por Kang, Mo-Yeol, Kim, Hyoung-Ryoul
    Publicado 2014
    “…BACKGROUND: The aim of this research was to investigate the association between job loss and the development of stroke or cardiovascular disease among middle-aged to older individuals in Korea. We also examined how this relationship was modified by gender and the nature of the job loss. …”
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    Association between Voluntary/Involuntary Job Loss and the Development of Stroke or Cardiovascular Disease: A Prospective Study of Middle-Aged to Older Workers in a Rapidly Developing Asian Country
  7. 4727
    “…We aim to examine the strength of association of single and multimorbid physical chronic diseases with self-rated health in a middle-aged and older population in England, and to determine whether any association is mediated by depression and other psychosocial factors. …”
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    Association of self-rated health with multimorbidity, chronic disease and psychosocial factors in a large middle-aged and older cohort from general practice: a cross-sectional study
  8. 4728
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    Excessive left ventricular trabeculation does not promote cardiac dysfunction in asymptomatic middle aged and older individuals with preserved cardiac function: an analysis from the Multi-Ethnic Study of Atherosclerosis
  9. 4729
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    Assessing cardiometabolic risk in middle-aged adults using body mass index and waist–height ratio: are two indices better than one? A cross-sectional study
  10. 4730
    “…BACKGROUND: To examine whether elevated glycosylated hemoglobin A1c (HbA1c) is associated with hyperfiltration in a middle-aged and elderly Chinese population. METHODS: Anthropometric and biochemical examinations were performed in 2491 individuals from the general population, aged 40–79 years, who participated in the Huaian Diabetes Prevention Program. …”
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    Association of elevated glycosylated hemoglobin A1c with hyperfiltration in a middle-aged and elderly Chinese population with prediabetes or newly diagnosed diabetes: a cross-sectional study
  11. 4731
    “…The sex difference in the prevalence rates of diabetes and cardiovascular diseases (CVDs) among the middle-aged population in China remain largely unknown. …”
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    Sex-Specific Prevalence of Diabetes and Cardiovascular Risk Factors in the Middle-Aged Population of China: A Subgroup Analysis of the 2007–2008 China National Diabetes and Metabolic Disorders Study
  12. 4732
    “…METHODS: The participants were 615 middle-aged men who were free from serious liver disorders, diabetes, and HS/VFA and underwent multiple general health check-ups at our institution between 2009 and 2013. …”
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    The Relationships between Metabolic Disorders (Hypertension, Dyslipidemia, and Impaired Glucose Tolerance) and Computed Tomography-Based Indices of Hepatic Steatosis or Visceral Fat Accumulation in Middle-Aged Japanese Men
  13. 4733
    por Choi, Jihyun E, Ainsworth, Barbara E
    Publicado 2016
    “…OBJECTIVE: To examine the associations of food consumption, serum vitamins and metabolic syndrome risk with physical activity level in middle-aged adults. DESIGN: Cross-sectional. SETTING: National Health and Nutrition Examination Survey (NHANES) 2005–2006. …”
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    Associations of food consumption, serum vitamins and metabolic syndrome risk with physical activity level in middle-aged adults: the National Health and Nutrition Examination Survey (NHANES) 2005–2006
  14. 4734
    “…Our study aimed to investigate spontaneous brain activity in patients with late middle-aged MB using the amplitude of low-frequency fluctuation (ALFF) method and their relationship with clinical features. …”
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    Altered spontaneous brain activity pattern in patients with late monocular blindness in middle-age using amplitude of low-frequency fluctuation: a resting-state functional MRI study
  15. 4735
    “…RESULTS: From 2005 to 2012, current smoker prevalence among the middle-aged Japanese population decreased from 30.5% to 24.3%. …”
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    Tobacco price increase and smoking behaviour changes in various subgroups: a nationwide longitudinal 7-year follow-up study among a middle-aged Japanese population
  16. 4736
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    Lower insulin sensitivity is related to lower relative muscle cross-sectional area, lower muscle density and lower handgrip force in young and middle aged non-diabetic men
  17. 4737
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    Incidence and long-term outcome of severe asthma–COPD overlap compared to asthma and COPD alone: a 35-year prospective study of 57,053 middle-aged adults
  18. 4738
    “…OBJECTIVE: This study aims to investigate the association of long-term weight-change slopes, weight fluctuation and the risk of type 2 diabetes mellitus (T2DM) in middle-aged Japanese men and women. METHODS: A total of 4234 participants of Aichi Workers' Cohort Study who were aged 35–66 years and free of diabetes in 2002 were followed through 2014. …”
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    Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study
  19. 4739
    “…Additionally, FLX reduced the deposition of beta amyloid, inhibited GSK-3β activity and increased the level of β-catenin in middle-aged APP/PS1 mice. Collectively, the results of this study indicate that FLX delayed the progression of neuronal loss in the hippocampal DG in middle-aged AD mice, and this effect may underlie the FLX-induced improvement in learning ability. …”
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    Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice
  20. 4740
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    Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients
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