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  1. 5261
    “…North-south structure is temporally stable, with west-east differentiation more transient, potentially influenced by migrations during the middle ages. Despite superexponential population growth, regional demographic estimates reveal population crashes contemporaneous with the Black Death. …”
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    Dutch population structure across space, time and GWAS design
  2. 5262
    “…OBJECTIVE: To assess the prevalence and severity of periodontitis based on different diagnostic methods in a historical Austrian population from the early middle ages. BACKGROUND: The description of the oral health status of archaeological material can provide interesting insights into prevalence, severity, and extent of oral diseases. …”
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    Prevalence and severity of periodontal disease in a historical Austrian population
  3. 5263
    “…We classified participants as having ideal, intermediate, or poor levels of the seven cardiovascular health metrics at four developmental stages: early (ages 9–11), middle (ages 12–14), and late (ages 15–17) adolescence, and early young adulthood (ages ≥ 18). …”
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    Cardiovascular health decline in adolescent girls in the NGHS cohort, 1987–1997
  4. 5264
    “…Our results show that the wild type is used throughout the series, up to the Middle Ages. In addition, domestic forms, morphologically related to southern varietal groups, are very early involved in the Champagne grape agrodiversity. …”
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    Seed morphology uncovers 1500 years of vine agrobiodiversity before the advent of the Champagne wine
  5. 5265
    “…METHODS: We collected BMSCs from mice at early to middle ages and compared their self-renewal and differentiation potential. …”
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    Transcriptomic alterations underline aging of osteogenic bone marrow stromal cells
  6. 5266
    por Heinz, Andreas, Daedelow, Laura S.
    Publicado 2021
    “…Alcohol is the dominant drug in Western societies with a history that spans from the Middle Ages through the colonial times to the present day. …”
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    Alkohol als Kulturgut – eine historisch-anthropologische und therapeutische Perspektive auf Alkoholkonsum und seine soziale Rolle in westlichen Gesellschaften
  7. 5267
    “…DISCUSSION: Building on these results, we suggest central Middle Ages as the most probable age of foundation for three of the considered Commons, the remaining one pointing to late antiquity. …”
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    Y‐chromosome variability and genetic history of Commons from Northern Italy
  8. 5268
    “…Origanum majorana L. is an aromatic herb that has been grown in several Mediterranean countries since ancient times, but became popular during the Middle Ages as a medicinal plant and seasoning ingredient. …”
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    Origanum majorana L.: A Nutritional Supplement With Immunomodulatory Effects
  9. 5269
    “…The results show a twofold shift between the Late Iron Age and the Middle Ages, from table to wine grape varieties and from eastern to western origins which correlates with previous palaeogenomic results.…”
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    Pip shape echoes grapevine domestication history
  10. 5270
    “…The Abbey of San Leonardo in Siponto (Apulia, Southern Italy) was an important religious and medical center during the Middle Ages. It was a crossroads for pilgrims heading along the Via Francigena to the Sanctuary of Monte Sant’Angelo and for merchants passing through the harbor of Manfredonia. …”
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    Genetic Evidence of the Black Death in the Abbey of San Leonardo (Apulia Region, Italy): Tracing the Cause of Death in Two Individuals Buried with Coins
  11. 5271
    por Abanmy, N., Alsabhan, J., Gard, P., Scutt, G.
    Publicado 2021
    “…In addition the impact of SSRI use on cognition improvement will be assessed. Healthy young, middle ages (25–59 years old) and elderly (more than 60 years old) participants (140) as well as 40 AD patients of whom are both of Saudi Arabian origin were recruited. …”
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    Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer’s disease patients
  12. 5272
    “…The efficacy of the method is demonstrated by comparing Copper Age populations of the Carpathian Basin to Middle Age ones and modern Hungarians. Our analysis reveals significant population continuity since the Middle Ages, and the presence of a substrate component since the Copper Age. …”
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    A new linear combination method of haplogroup distribution central vectors to model population admixtures
  13. 5273
    “…Based on the genomic data alone, the origin of C. difficile RT 017 could not be determined; however, geographical data and records of population movement suggest that C. difficile RT 017 had been moving between Asia and Europe since the Middle Ages and was later transported to North America around 1860 (95 % confidence interval: 1622–1954). …”
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    Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017
  14. 5274
    “…CONCLUSION: The pattern of cancer diagnoses in rural hospitals shows an exceptionally high burden in women in their middle-ages due to breast and cervical cancers. Advanced stage presentation, lack of pathology services, and unavailability of most systemic treatment options were common. …”
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    Burden of Cancer and Utilization of Local Surgical Treatment Services in Rural Hospitals of Ethiopia: A Retrospective Assessment from 2014 to 2019
  15. 5275
    “…We then partitioned our dataset into middle- (ages 40 to 65 y, n = 300) and old- (ages 65 to 90 y, n = 178) aged subjects and observed that older individuals had less robust core connectivity and resilience. …”
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    A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
  16. 5276
    “…CONCLUSIONS: Most causes of natural deaths were in the middle ages with the noncommunicable diseases (NCDs) accounting for a significant proportion. …”
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    The Magnitude of Medicolegal Postmortem That Turned Out to Be Natural Deaths at the University of Benin Teaching Hospital: A 3-Year Study
  17. 5277
    por Nezami, Esmaeil, Gallego, Pedro P.
    Publicado 2023
    “…Native to southern Central Asia (including northern Afghanistan and northeastern Iran), its domestication and cultivation occurred about 3000 years ago in this region, spreading to the rest of the Mediterranean basin during the Middle Ages and finally being exported to America and Australia at the end of the 19th century. …”
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    History, Phylogeny, Biodiversity, and New Computer-Based Tools for Efficient Micropropagation and Conservation of Pistachio (Pistacia spp.) Germplasm
  18. 5278
    por Larsson, Mikael, Foley, Brendan
    Publicado 2023
    “…Exotic spices were status markers among the aristocracy in Scandinavia and around the Baltic Sea during the Middle Ages (1050–1550 CE). Until the Gribshunden finds, these extravagances have rarely or never been represented archaeologically. …”
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    The king’s spice cabinet–Plant remains from Gribshunden, a 15(th) century royal shipwreck in the Baltic Sea
  19. 5279
    “…While age is an important predictor of hypertension risk, even in middle ages 45–55 years, hypertension is already widespread. …”
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    Aging and hypertension among the global poor—Panel data evidence from Malawi
  20. 5280
    “…The population that used tobacco had a higher proportion of women, those who were White, non‐Hispanic, and those in their middle ages (21–60) than the group that did not use tobacco. …”
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    Tobacco use in Crohn's disease patients and association with disease outcomes in the United States Medicaid population, 2010–2019
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