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  1. 5501
    “…The aim of the present study was to investigate whether microglia in the middle-aged CNS already react differently to demyelination. …”
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    Age Influences Microglial Activation After Cuprizone-Induced Demyelination
  2. 5502
    “…OBJECTIVE: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. METHODS: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). …”
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    Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort
  3. 5503
    “…RESULTS: Young participants had a lower muscle MRI T2, FF and mean diffusivity than middle-aged and older participants; middle-aged participants had lower values than older participants. …”
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    The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: an association with frailty and muscle strength
  4. 5504
    “…In our analyses, we compared satisfaction ratings of middle-aged (40–64 years) and older individuals (65–79 years) and found that both middle-aged and older participants experienced the greatest decreases in satisfaction with social contacts, with more pronounced decreases seen in middle-aged participants. …”
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    Aging during COVID-19 in Germany: a longitudinal analysis of psychosocial adaptation
  5. 5505
    “…Differentially expressed (DE) proteins in the cortical microvessels (MVs) of young, middle-aged, and old male and female mice were evaluated using discovery-based proteomics analysis (> 4,200 quantified proteins/group). …”
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    Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components
  6. 5506
    “…The average total DHI score in the middle-aged group was significantly higher than that in older adults group 2 (52.86 vs. 35.04, P = 0.032), and the Beck anxiety score in the middle-aged group was higher than that in older adults group 2 (38.89 vs. 27.65, P = 0.000). …”
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    Older patients with persistent postural-perceptual dizziness exhibit fewer emotional disorders and lower vertigo scores
  7. 5507
    por Yuan, Ye, Li, Juan, Yao, Liang
    Publicado 2022
    “…Notably, the proportion of organic carbon protected within microaggregates was significantly higher in the middle-aged plantation (40.4%) than those in the young plantation (29.2%) and the mature plantation (27.8%), indicating that the middle-aged Cunninghamia lanceolata plantation had stronger soil organic carbon stability. …”
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    Soil microbial community and physicochemical properties together drive soil organic carbon in Cunninghamia lanceolata plantations of different stand ages
  8. 5508
    “…METHODS: Young (< 40 years), middle-aged (40-to-60 years), and older (> 60 years) adults, who underwent an FDG-PET/CT, were prospectively recruited. …”
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    Volume of the proximal half of the thoracic aorta is the most comprehensive FDG-PET/CT indicator of arterial aging throughout adulthood
  9. 5509
    “…[Ca(2+)](i) was reduced to 134 ± 8 nM in middle-aged muscle and to 246 ± 40 nM in muscle from aged mice. …”
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    Senescence Is Associated With Elevated Intracellular Resting [Ca(2 +)] in Mice Skeletal Muscle Fibers. An in vivo Study
  10. 5510
    “…METHODS: We included 4739 individuals aged ≥ 40 years and without diagnosed diabetes or CVD history, and divided them into middle-aged adults (age < 60) and older adults (age ≥ 60). …”
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    Age-specific difference in the association between prediabetes and subclinical atherosclerosis: an analysis of a chinese prospective cohort study
  11. 5511
    “…There were no statistically significant differences in gastroenterologist's preference weights for the middle-aged versus young patient profiles. However, preference weights indicated that gastroenterologists are more concerned about 5% side-effect risks for the older patient profile than for the middle-aged patient profile. …”
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    Are Gastroenterologists Less Tolerant of Treatment Risks than Patients? Benefit-Risk Preferences in Crohn's Disease Management
  12. 5512
    “…By utilizing a single-cell transcriptomic atlas of mouse skeletal muscle across the lifespan, we identified a clear sign of immune senescence that presents during middle age. More importantly, the change in macrophage phenotype in middle age may explain the changes in extracellular matrix composition, especially collagen synthesis, that contributes to fibrosis and overall muscle weakness with advanced age. …”
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    Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan
  13. 5513
    por Killikelly, Clare, Szűcs, Dénes
    Publicado 2013
    “…Delayed P3b latency and increased amplitude revealed that middle age adults have a deficit in stimulus processing. …”
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    Asymmetry in stimulus and response conflict processing across the adult lifespan: ERP and EMG evidence()
  14. 5514
    “…The objectives of this study were to establish (1) if brain SERT expression is reduced by aging and (2) if the SERT expression in middle-aged rats is increased by T-restitution. Intact young rats (3–5 months) and gonad-intact middle-aged rats with or without T-restitution were used. …”
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    Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution
  15. 5515
    “…Elderly patients had a similar rate of tumour extension but had poorer survival as compared with the middle-aged patients. Post-operative death within 30 days after surgery was also higher in the elderly than in the middle-aged patients.…”
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    Clinicopathological characteristics of gastric cancer in the elderly.
  16. 5516
    “…In this study, we investigate the therapeutic effects of AV-001, a Tie2 receptor agonist, in middle-aged rats subjected to a multiple microinfarct (MMI) model of VaD. …”
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    Treatment With an Angiopoietin-1 Mimetic Peptide Improves Cognitive Outcome in Rats With Vascular Dementia
  17. 5517
    “…The participants were divided into four groups based on age and sex (young male, middle-aged male, young female and middle-aged female groups). …”
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    Transition Patterns of Weight Status and Their Predictive Lipid Markers Among Chinese Adults: A Longitudinal Cohort Study Using the Multistate Markov Model
  18. 5518
    “…We tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle-aged adults. METHODS: We conducted a prospective MRI neuroimaging study in middle-aged persons without stroke, dementia, or multiple sclerosis enrolled in the UK Biobank. …”
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    Suboptimal Sleep Duration is Associated with Poorer Neuroimaging Brain Health Profiles
  19. 5519
    “…Stratified analysis demonstrated that middle-aged patients exhibited better survival than young patients, with the exception of patients with stage III disease. …”
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    Effect of Age on Breast Cancer Patient Prognoses: A Population-Based Study Using the SEER 18 Database
  20. 5520
    “…RESULTS: Adult GluK2(−/−) mice exhibit an improved glucose tolerance (OGTT and IPGTT), and this was also apparent in middle-aged mice, whereas the outcome of pyruvate challenge was slightly improved only in middle-aged GluK2(−/−) mice. …”
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    The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging
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