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  1. 5581
    “…RESULTS: A total of 136 women (middle-aged group, 106; elderly group, 30) were enrolled in the study. …”
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    Long-term Clinical Outcomes of the Tension-free Vaginal Tape Procedure for the Treatment of Stress Urinary Incontinence in Elderly Women over 65
  2. 5582
    “…RESULTS: Fat mass increased in the middle-aged control condition (+49%) but not the middle-aged HMB condition. …”
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    Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats
  3. 5583
    “…The participants were divided into 2 age groups: middle-aged (40 to 69 years; mean age 55 years) and elderly (70 to 89 years; mean age 75 years). …”
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    Relation Between Serum Total Cholesterol Level and Cardiovascular Disease Stratified by Sex and Age Group: A Pooled Analysis of 65 594 Individuals From 10 Cohort Studies in Japan
  4. 5584
    “…We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of middle-aged ovariectomized rats, but not in young ones reflecting elevated expression of these genes in middle-aged, ovarian hormone deficient animals. …”
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    Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes
  5. 5585
    “…RESULTS: There were no significant differences among young, middle-aged, and old groups in terms of OS (P=0.087), whereas PFS in the old group was significantly better than in the young and middle-aged groups (P=0.043). …”
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    Clinical outcome of advanced and metastatic renal cell carcinoma treated with targeted therapy: is there a difference between young and old patients?
  6. 5586
    “…Methods: Twenty-nine young (15 women and 14 men; 27.3 y ± 5.0) and 31 middle-aged (19 women and 13 men; 51.6 y ± 5.1) healthy subjects participated in a baseline nocturnal sleep and a daytime recovery sleep after 25 hours of sleep deprivation. …”
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    Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation
  7. 5587
    “…MATERIALS AND METHODS: Subjects with recent‐onset diabetes were selected from a nationwide survey data and classified according to age: elderly (age ≥75 years), middle‐age (age 45–64 years) and young (age 25–39 years). …”
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    Difference between old and young adults in contribution of β‐cell function and sarcopenia in developing diabetes mellitus
  8. 5588
    “…These observations hold for both middle-aged and older men. For women, the picture is less uniform. …”
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    Socioeconomic disparities in lung cancer mortality in Belgian men and women (2001-2011): does it matter who you live with?
  9. 5589
    “…The patients were divided into the following four age cohorts: middle-aged (55–64), young-old (65–74), middle-old (75–84), and old-old (≥85). …”
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    Short- and Long-Term Mortality Rates of Elderly Acute Kidney Injury Patients Who Underwent Continuous Renal Replacement Therapy
  10. 5590
    “…Safety, pharmacokinetics and pharmacodynamics of idarucizumab were investigated in dabigatran-treated, middle-aged, elderly and renally impaired volunteers with characteristics similar to patients receiving anticoagulant therapy. …”
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    Effect of Age and Renal Function on Idarucizumab Pharmacokinetics and Idarucizumab-Mediated Reversal of Dabigatran Anticoagulant Activity in a Randomized, Double-Blind, Crossover Phase Ib Study
  11. 5591
    “…The adult population was divided into three age groups (young, 30–49; middle-aged, 50–69; and old, 70–84 years); only the middle-aged were eligible for NCCS. …”
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    Effects of screening and universal healthcare on long-term colorectal cancer mortality
  12. 5592
    “…CONCLUSIONS: The national CBHMS is more likely to be used by rural middle-aged and older adults with hypertension in China. …”
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    Urban-rural disparity in the utilization of national community-based hypertension monitoring service—results from the China Health and Retirement Longitudinal Study, 2015
  13. 5593
    “…With the exception of middle-aged men, walking is associated with lower premature cardiometabolic death. …”
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    Active living environments, physical activity and premature cardiometabolic mortality in Canada: a nationwide cohort study
  14. 5594
    “…In young and middle-aged patients, critical patients showed higher high-sensitivity C-reactive protein (hsCRP) during hospitalization than severe patients. …”
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    Different characteristics of critical COVID-19 and thinking of treatment strategies in non-elderly and elderly severe adult patients
  15. 5595
    “…The Score for Trauma Triage in Geriatric and Middle Aged (STTGMA) was calculated using patient demographics, injury severity, and functional status. …”
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    Ability of a Risk Prediction Tool to Stratify Quality and Cost for Older Patients With Operative Distal Radius Fractures
  16. 5596
    “…Replacement of hydrocortisone was commonly associated both in young and middle-aged group (P =0.04), and in older group (P =0.02). …”
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    The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment
  17. 5597
    “…OBJECTIVES: This study aimed to investigate the associations between several dimensions of self-reported satisfaction and the risk of depressive symptoms among Chinese middle-aged and older adults. METHODS: The China Health and Retirement Longitudinal Study (CHARLS) conducted a nationwide cross-sectional study of middle-aged and older adults. …”
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    The higher levels of self-reported satisfaction, the lower risk of depressive symptoms: Evidence from a nationwide cross-sectional study in China
  18. 5598
    “…Significant age-related alterations in circadian entrainment of the activity rhythm were observed in the middle-aged and aged cohorts. In middle-aged mice, the delayed phase angle of entrainment and increased variability in the daily onsets of activity preceded learning and memory deficits observed in aged animals. …”
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    Development of an age-dependent cognitive index: relationship between impaired learning and disturbances in circadian timekeeping
  19. 5599
    “…OBJECTIVE: This study aimed to estimate the occurrence of depressive symptoms in a global population of young, middle-aged and older adults amid the COVID-19 pandemic. …”
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    Global occurrence of depressive symptoms during the COVID-19 pandemic
  20. 5600
    “…CONCLUSION: CB‐PVI had similar efficacy and safety in YOUNG and MIDDLE‐AGED patients. Younger age did not affect acute procedural results, complication rate, or AF recurrence after a single procedure.…”
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    Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project
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