“…Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population. In this study, we explore the effect of high fat diet on the development of metabolic syndrome in middle-aged mice and to evaluate the potential benefits of voluntary physical exercise on the periphery as well as brain cognitive function, and to explore the potential mechanisms. …”
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“…INTRODUCTION: The increase in the suicide mortality rate among middle-aged adults in the United States (US) has been well documented. …”
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“…After middle age, cognition declined independently of change in functional limitation. …”
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“…This study aimed to investigate the association between denture use, chewing ability, and cognitive function in Korean middle-aged adults, using samples representing middle-aged people at the national level. …”
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“…Here, we examined cardiac and metabolic phenotypes in relation to inflammatory status and antioxidant capacity in young, middle-aged and old mice. Real-time reverse transcription–polymerase chain reactions were performed on myocardium and immunoassays on plasma. …”
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“…CONCLUSION: VA is practicable for deaths in early adult life or middle age and is of more limited value in old age. …”
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“…Results showed that a total of 503 (60 upregulated, 443 downregulated) and 84 (downregulated) genes were differentially expressed in old ovaries compared to young and middle-aged groups, respectively. No difference in gene expression was found between middle-aged and young groups. …”
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“…Age was also evaluated continuously and categorically [adolescent (16–17yrs), young adult (18–29yrs), early middle age (30–49 yrs), late middle age (50–6 4yrs), and older adult (≥65 yrs)]. …”
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“…The 5q33.3 locus has previously been associated with blood pressure regulation and cardiovascular diseases in middle-aged individuals. However, part of the influence on mortality appears to be independent of cardiovascular phenotypes, and the role of the 5q33.3 locus in longevity and survival is therefore still partly unknown. …”
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“…Middle aged with BMI≥25 kg/m(2) were more likely to lose weight (963/2807, 34.3%). …”
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“…Analyses were stratified by three age groups: 18–44 years (young adults), 45–64 years (middle-aged adults), and ≥65 years (older adults). Among young adults, cognitive disability (10.6%) was the most prevalent type. …”
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“…OBJECTIVE: The objective of this study was to investigate the interaction among the determinants of expiratory flow limitation (EFL), peak oxygen uptake (VO(2)peak), dysanapsis ratio (DR) and age during cycling at different intensities in young and middle-aged men. METHODS: Twenty-two (11 young and 11 middle-aged) men were assessed. …”
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“…Here, using in vivo two-photon imaging, we characterize intracellular Ca(2+) signaling and process extension of cortical microglia in young adult (2–4-month-old), middle-aged (9–11-month-old), and old (18–21-month-old) mice. …”
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“…We compared energy and nutrient intakes derived from dietary records (DR) and FFQ in an elderly population and compared the data against results from middle-aged individuals (30–68 years) from a previous study. …”
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“…Using cross-sectional data, we investigated differentiation and dedifferentiation processes in verbal fluency across the lifespan by analyzing the association between verbal fluency and numerous cognitive measures within four age groups (N=446): early middle-age (32-45 years), late middle-age (46-58 years), early elderly (59-71 years), and late elderly (72-84 years). …”
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“…Overall, movement performance in middle-aged and older adults was affected by visual occlusion, whereas it was unaffected in younger adults. …”
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“…Manifestation is usually in infancy or early childhood due to gradual decrease in hemoglobin F level as age advances. Diagnosis in middle age is unusual. We present a woman who was diagnosed of SCA for the first time at middle age. …”
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“…We used young (3–4 months old) and middle-aged (9–10 months old) Brown Norway rats. Menopause was induced by ovariectomy (OVX), and control animals underwent sham surgery, resulting in the following groups: young sham (n = 5), young OVX (n = 6), middle-aged sham (n = 5), and middle-aged OVX (n = 5). …”
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“…RESULTS: This study included 560 young drivers (19–25 years), 850 middle-aged drivers (26–59 years), and 354 old drivers (≥ 60 years). …”
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“…Here, we show that a significant expansion of BM-derived HSPCs occurs in the middle age of female but in the old age of male mice. …”
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