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  1. 10361
    “…Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregating TIAF1 induces generation of amyloid beta (Aβ) for causing neurodegeneration. …”
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    Self-aggregating TIAF1 in lung cancer progression
  2. 10362
    “…However, its natural history has not been fully elucidated because the first case was reported in the late 1960s and patients who have recovered are just now entering middle age. Nevertheless, much evidence has raised concerns regarding the subclinical vascular changes that occur in post-KD patients. …”
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    Understanding the importance of cerebrovascular involvement in Kawasaki disease
  3. 10363
    “…We have recently shown that this slow development is accelerated when middle-aged mice perform voluntary exercise in a running wheel. …”
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    Rejuvenating the Brain With Chronic Exercise Through Adult Neurogenesis
  4. 10364
    “…Cohorts of littermate, wild‐type C57BL/6 mice were studied at developmental ages analogous to human middle age through advanced age. Cardiac and aortic valve function were assessed with M‐mode echocardiography and pulsed wave Doppler ultrasound, respectively. …”
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    H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice
  5. 10365
    “…Similar results can be found in the middle-aged and obese population, with aOR (95% CI) of EAFH as 1.17 (1.05, 1.30) and 1.15 (1.03, 1.29), respectively. …”
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    Association between Eating Away from Home and Hyperuricemia: A Population-Based Nationwide Cross-Sectional Study in China
  6. 10366
    “…Individual age and sex influenced the probability of infections with some differences between parasites: while P. mandrilli appeared to infect its hosts rather randomly, P. gonderi particularly infected middle-aged mandrills. Males were also more susceptible to P. gonderi than females and were more likely to be infected by this parasite at the beginning of an infection by the simian immunodeficiency virus. …”
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    A longitudinal molecular study of the ecology of malaria infections in free-ranging mandrills
  7. 10367
    “…Of the 216 patients recruited, the majority were middle-aged (30–50 years old) married women. Development of psychological distress followed a U-shaped curve in relation to the number of chemotherapy doses received. …”
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    Epidemiological assessment of distress during chemotherapy: who is affected?
  8. 10368
    “…Wilson et al. use dyadic data from young and middle-aged couples to examine cardiometabolic similarity among spouses, and how such concordance is shaped by key relationship factors such as emotional closeness. …”
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    PHYSIOLOGY OF SUCCESSFUL AGING: IMPLICATIONS FOR HEALTH AND WELL-BEING
  9. 10369
    “…Yet, the majority of middle-aged and older adults do not engage in the recommended amount of exercise despite awareness of its widespread benefits. …”
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    THE RELATIONSHIP OF DAILY STEPS TO MOOD AND ENERGY: APPLICATION OF STEPMATE (MOBILE APP FOR TRACKING EXERCISE)
  10. 10370
    por Vecchione, Katia, Barrett, Anne
    Publicado 2019
    “…Known as “badanti,” most of these careworkers are middle-aged women from Eastern Europe. Although some research examines this phenomenon, it focuses exclusively on careworkers – not those receiving their care. …”
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    OLDER ITALIANS’ VIEWS OF AND EXPERIENCES WITH IMMIGRANT CAREWORKERS
  11. 10371
    “…The distribution of patients with different autoantibodies by age and sex was as follows: NMDAR (70%), mostly in young females, LGI1 (15%) in middle‐aged males, GABA(B)R (12%) in elderly males, and Caspr2 (7%) in males. …”
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    Single‐center study of autoimmune encephalitis‐related autoantibody testing in Hungary
  12. 10372
    “…Spinal cord injury (SCI) often occurs in young and middle-aged population. The present study aimed to clarify the function of Galectin-3 (Gal-3) in neuroinflammation of SCI. …”
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    Gal-3 is a potential biomarker for spinal cord injury and Gal-3 deficiency attenuates neuroinflammation through ROS/TXNIP/NLRP3 signaling pathway
  13. 10373
    por LuLu, Xu, Jian, Shu
    Publicado 2019
    “…Pulmonary sclerosing pneumocytoma (PSP) is an asymptomatic slow-growing benign tumor, which usually occurs in middle-aged women. PATIENT CONCERNS: Herein, we report a case of solitary PSCC, occurring concomitantly with PSP in a 74-year-old woman. …”
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    Concomitance of pulmonary spindle cell carcinoma and sclerosing pneumocytoma in a woman: A case report
  14. 10374
    “…This study aimed to investigate the effects of grape seed proanthocyanidin extract (GSPE) on blood pressure and vascular endothelial function in middle-aged Japanese adults with prehypertension. We conducted a randomized, double-blind, placebo-controlled study on 6 men and 24 women aged 40–64 years old. …”
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    Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study
  15. 10375
    “…Background: This study aims to examine the impact of individual-level and community-based factors on popular social participation activities of Chinese middle-aged and older adults post-stroke. Methods: Sub-samples of survivors of stroke (2011: n = 413, 2013: n = 395, 2015: n = 441) recruited by the China Health and Retirement Longitudinal Study (CHARLS) were included in the analysis. …”
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    Multi-Level Factors Associated with Social Participation among Stroke Survivors: China’s Health and Retirement Longitudinal Study (2011–2015)
  16. 10376
    “…These 3 tumors were most frequently found in middle-aged to elderly dogs without any sex predilection. …”
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    A retrospective survey on canine intracranial tumors between 2007 and 2017
  17. 10377
    “…BACKGROUND: Carotid atherosclerosis (CA) is a common disease in middle-aged and elderly people, which is closely related to cardiovascular and cerebrovascular disease. …”
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    Electrocardiogram-Based R Wave Pulse Wave Index for Assessment of Carotid Atherosclerosis
  18. 10378
    “…Therefore, the aim of this review was to analyze the diagnostic tools of CD used in middle-aged women, to compare the use and effectiveness of the different tools, and to propose a strategy for the use of the tools based on the results found in the literature. …”
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    Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach
  19. 10379
    “…The significant slowing of gait speed while texting from middle age may be a marker of neurodegeneration, a cohort effect, or an appropriate compensatory response to reduce the risk of injury.…”
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    The Effect of Age on Gait Speed When Texting
  20. 10380
    “…CONCLUSION: Scrotal leiomyoma is a rare benign mesenchymal tumor of the middle-aged men. The current report describes the clinical and histopathological characteristics to help reduce erroneous diagnoses of this rare tumor.…”
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    Typical leiomyoma of the scrotum: A rare case report
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