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  1. 10401
    “…Background and Objectives: Metabolic syndrome (MetS) is a multiple risk factor for atherosclerosis, cardiovascular disease, type 2 diabetes and strokes. One-third of middle-age women are at risk of MetS, which predisposes them to type 2 diabetes and cardiovascular disease. …”
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    The Relationship between the IFNG (rs2430561) Polymorphism and Metabolic Syndrome in Perimenopausal Women
  2. 10402
    “…Many significant relationships were found in young males (aged 20–39) and middle-aged females (aged 40–59). These findings can be used as lifestyle guidance for disease prevention although the causal relationships should be confirmed.…”
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    Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness
  3. 10403
    por Chen, Xi, Gao, Haiyan, Zou, Yuchun, Lin, Fen
    Publicado 2020
    “…The results showed that the prevalence of psychological distress dropped from over 75% to around 15% throughout the study period, but perceived discrimination remained stable. Female, middle-aged, well-educated respondents and those employed in government/public institutions/state-owned enterprises tended to report more distress. …”
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    Changes in psychological wellbeing, attitude and information-seeking behaviour among people at the epicentre of the COVID-19 pandemic: a panel survey of residents in Hubei province, China
  4. 10404
    “…Previous studies have suggested that cadmium was a potential CVD risk factor in the overall and middle-aged to elderly populations. We assessed the associations between cadmium and CVD events in the Korean population aged 20–59 years using the 2008–2013 and 2016 Korea National Health and Nutrition Examination Survey (KNHANES), a population-based cross-sectional study. …”
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    Association of Blood Cadmium with Cardiovascular Disease in Korea: From the Korea National Health and Nutrition Examination Survey 2008–2013 and 2016
  5. 10405
    “…The results show that explicitly measured supportive attitudes towards intimate partner violence against women differ between age groups, adopting a U-shape distribution: lower acceptance among middle-aged-adults and young-adults and higher acceptance among adolescents and older adults. …”
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    Psychosocial Implications of Supportive Attitudes towards Intimate Partner Violence against Women throughout the Lifecycle
  6. 10406
    “…The risk of ischemic stroke in patients with dyslipidaemia, diabetes mellitus, and hypertension was higher in middle-aged and old patients.…”
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    A snapshot of Ischemic stroke risk factors, sub-types, and its epidemiology: Cohort study
  7. 10407
    “…Several reports link telomere biology and reproduction, but the molecular reasons for the rapid loss of ovarian function at middle age are still elusive. This review will focus on the knowledge acquired during the last years about ovarian aging and disease, both in mouse models of reproductive senescence and in humans with ovarian failure, and the implication of telomeres in this process. …”
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    Impact of Ovarian Aging in Reproduction: From Telomeres and Mice Models to Ovarian Rejuvenation
  8. 10408
    “…Alterations of structural network parameters, including intra- and inter-lobe connectivity, were detected in a middle-aged group (30–45 years old) and an elderly group (50–65 years old). …”
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    Alteration of the Intra- and Inter-Lobe Connectivity of the Brain Structural Network in Normal Aging
  9. 10409
    “…TECs induced from FOXN1-overexpressing embryonic fibroblasts can generate an ectopic de novo thymus under the kidney capsule, and intrathymic injection of naturally young TECs can lead to middle-aged thymus regrowth. Therefore, as a thymic rejuvenation strategy, we extended these 2 findings by combining them with 2 types of promoter-driven (Rosa26CreER(T) and FoxN1Cre) Cre-mediated FOXN1-reprogrammed embryonic fibroblasts (FREFs). …”
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    Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation
  10. 10410
    “…Upon review of the literature, we found that blastocystis induced ReA affects mainly young and middle-aged females such as in our case. The arthritis is usually settled with the parasite eradication. …”
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    An unusual cause of reactive arthritis with urticarial: A case report
  11. 10411
    “…Therefore, encouraging dietary calcium intake among middle-aged and older adults for preservation of muscle mass should be considered.…”
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    Longitudinal Observation of Muscle Mass over 10 Years According to Serum Calcium Levels and Calcium Intake among Korean Adults Aged 50 and Older: The Korean Genome and Epidemiology Study
  12. 10412
    “…Little is known about the association of glucose metabolism and retinopathy signs in the non-diabetic middle-aged population. We studied prevalence of retinopathy in a subsample of Northern Finland Birth Cohort study (NFBC1966) of 1809 subjects, at 47 years of age, without previously diagnosed type 2 diabetes and/or blood pressure-lowering medication. …”
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    Association of glucose metabolism and retinopathy signs in non-diabetic individuals in midlife—The Northern Finland Birth Cohort 1966 study
  13. 10413
    “…However, the beneficial effects of metformin in middle-aged normoglycemic mice are less explored. Here, we report that metformin treated by tail vein injection improved cognitive function of aged mice better than oral administration, which seem to show a dose-dependent manner. …”
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    Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis
  14. 10414
    “…It was also found that central neural gain after acoustic trauma was linked to hippocampal long-term potentiation (LTP) and upregulation of brain-derived neurotrophic factor (BDNF). Using middle-aged and old BDNF-live-exon-visualization (BLEV) reporter mice we analyzed the specific recruitment of LTP and the activity-dependent usage of Bdnf exon-IV and -VI promoters relative to cochlear synaptopathy and central (temporal) processing. …”
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    Age-Dependent Auditory Processing Deficits after Cochlear Synaptopathy Depend on Auditory Nerve Latency and the Ability of the Brain to Recruit LTP/BDNF
  15. 10415
    “…It usually affects young and middle-aged adults with no gender predilection. Chest radiographs usually show a pleural-based mass, parenchymal consolidation, or a near complete opacification of the hemithorax. …”
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    A rare case of pleuropulmonary synovial sarcoma of the chest wall: A case report and a literature review
  16. 10416
    “…Prevention and care for dental caries for all age groups and periodontal disease for over middle age groups are required.…”
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    Reasons for Permanent Tooth Extractions in Japan
  17. 10417
    “…CASE PRESENTATION: A middle-aged patient from a rural, semi-arid region who presented with pain, redness, and a foreign-body sensation in his left eye resulting from a corneal ulcer induced by trauma from a wooden stick. …”
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    Indolent keratitis due to fungus of Malbranchea species. A case report
  18. 10418
    por Castle, George, Heath, Greg
    Publicado 2020
    “…We report the case of a previously fit middle-aged patient presenting with painless loss of vision and loss of appetite. …”
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    Endogenous Klebsiella endophthalmitis as the presentation of both Klebsiella liver abscess and underlying anti-IFN-3 autoimmunity
  19. 10419
    “…We included participants from a wide age range spanning young, middle-aged and elderly adults. All of them performed a STM task that has previously been shown to be sensitive to subtle changes in memory in various patient and at-risk cohorts. …”
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    Superior short-term memory in APOE ε2 carriers across the age range
  20. 10420
    “…The present study examined the moderating effect of perceived partner responsiveness (PPR) on the association between menopausal symptoms (MS) and depressed affect (DA). The sample was middle-aged climacteric women (N = 754, Age=49-60) from the second wave of Midlife in the United States (MIDUSⅡ). …”
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    Perceived Partner Responsiveness Attenuate the Link Between Menopausal Symptoms and Depressed Affect
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