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  1. 10601
    “…We found mild vascular deficits: vascular density and functional hyperaemia were unaffected in APOE4 mice, and neuronal or vascular function did not decrease up to late middle-age. Instead, vascular responsiveness was lower, arteriole vasomotion was reduced and neuronal calcium signals during visual stimulation were increased. …”
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    APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice
  2. 10602
    “…The relations were examined between colorectal cancer and cigarette smoking and alcohol consumption within the Singapore Chinese Health Study, a population-based, prospective cohort of 63 257 middle-aged and older Chinese men and women enrolled between 1993 and 1998, from whom baseline data on cigarette smoking and alcohol consumption were collected through in-person interviews. …”
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    Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study
  3. 10603
    por Sasieni, P, Adams, J, Cuzick, J
    Publicado 2003
    “…This calls into question the policy of having a uniform screening interval from age 20 to 64 years and stresses the value of screening in middle-aged women.…”
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    Benefit of cervical screening at different ages: evidence from the UK audit of screening histories
  4. 10604
    “…Cross-sectional data have been derived from the baseline examination of an epidemiological cohort study of 4.814 middle aged urban inhabitants in Germany (Heinz Nixdorf Recall Study). …”
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    Low socio-economic position is associated with poor social networks and social support: results from the Heinz Nixdorf Recall Study
  5. 10605
    “…It is mainly reported by middle aged females who tend to recognize the symptoms more readily than males and therefore more commonly seek professional help. …”
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    Muscle disorders and dentition-related aspects in temporomandibular disorders: controversies in the most commonly used treatment modalities
  6. 10606
    “…Disease genes also have higher mRNA expression heterogeneity across multiple tissues than non-disease genes regardless of age and PGL. Young and middle-aged disease genes have fewer similar paralogs as non-disease genes of the same age. …”
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    Similarly Strong Purifying Selection Acts on Human Disease Genes of All Evolutionary Ages
  7. 10607
    “…However, most heart failure patients treated with CRT are middle-aged or old patients with idiopathic or ischemic dilated cardiomyopathy. …”
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    Effective cardiac resynchronization therapy for an adolescent patient with dilated cardiomyopathy seven years after mitral valve replacement and septal anterior ventricular exclusion
  8. 10608
    “…CONCLUSIONS: Low serum IGF-I levels in this cohort of older middle-aged male smokers are associated with increased kidney cancer risk, independent of IGFBP-3.…”
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    Insulin-like growth factors and risk of kidney cancer in men
  9. 10609
    “…METHODOLOGY/PRINCIPAL FINDINGS: We analyzed data from a prospective cohort study of 51,251 middle-aged or older (45–74) Chinese men and women in the Singapore Chinese Health Study. …”
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    BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study
  10. 10610
    “…Risk age is a relatively good predictor of 10-yr mortality in Korean men and may be useful in identifying high-risk middle-aged men for health interventions.…”
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    Predictive Accuracy of a Health Risk Appraisal Program Using Mortality Risk Age in 116,927 Korean Men
  11. 10611
    “…History of obesity in middle age had a weak and not significant adverse effect among obese women (OR=1.60; 95% CI: 0.52–4.96). …”
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    Anthropometric measures at different ages and endometrial cancer risk
  12. 10612
    “…The mean life span of tumor-free mice was increased by 21% in ‘the youngest group’, by 7% in ‘middle-aged group’ and in contrast was reduced by 13% in ‘the oldest group’. …”
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    If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
  13. 10613
    “…According to univariate analysis, users were commonly identified among middle-aged or older patients; unadjusted ORs were 2.1 (95% CI: 1.3–3.3) for patients aged 48–69 years, and 3.0 (95% CI: 1.9–4.7) for those of 70–95 years, when compared with individuals aged 18–47 years. …”
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    Complementary and Alternative Drugs Use among Preoperative Patients: A Cross-Sectional Study in Italy
  14. 10614
    “…METHODS: The MST, assessing maximal step-up height (MSH) in 3-cm increments, was evaluated in 60 healthy middle-aged subjects, 30 women and 30 men. The repeatability of MSH and the correlation between MSH and isokinetic knee extension peak torque (IKEPT), self-reported physical function (SF-36, PF), patient demographics and self-reported physical activity were investigated. …”
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    Repeatability and validity of a standardised maximal step-up test for leg function-a diagnostic accuracy study
  15. 10615
    “…The disease demonstrates an overwhelming female preponderance and virtually all women with PBC present in middle age. The reasons for this are unknown; however several environmental and immunological factors may be involved. …”
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    Immunopathogenesis of primary biliary cirrhosis: an old wives' tale
  16. 10616
    “…Idiopathic central serous chorioretinopathy (CSC) typically affects middle-aged males. To date, only one case of idiopathic CSC in a prepubertal subject has been reported. …”
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    Presumed Idiopathic Central Serous Chorioretinopathy in a 12-Year-Old Girl
  17. 10617
    “…METHODS: We estimated relative risks (RR) of breast and other invasive cancers by the reported frequency of daytime napping in a large prospective cohort of middle-aged women in the UK. RESULTS: During an average of 7.4 years of follow-up, 20 058 breast cancers and 31 856 other cancers were diagnosed. …”
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    A short-term increase in cancer risk associated with daytime napping is likely to reflect pre-clinical disease: prospective cohort study
  18. 10618
    “…While gliomas occur in children, most meningiomas are slow-growing tumors affecting middle-aged individuals with progressive visual loss, proptosis, disc edema and optociliary veins on fundus examination. …”
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    Optic Nerve Sheath Meningioma in the First Decade of Life: Case Report and Review of the Literature
  19. 10619
    “…CRP has been shown to predict cardiovascular (CV) mortality in recent studies, and elevated CRP levels have been observed in middle-aged patients with periodontitis. Combination of chronic infections like periodontitis with elevated CRP is associated with higher chronic heart diseases. …”
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    A review of C-reactive protein: A diagnostic indicator in periodontal medicine
  20. 10620
    por Ritchie, Craig W, Ritchie, Karen
    Publicado 2012
    “…INTRODUCTION: Epidemiological studies indicate that significant decreases in the incidence of Alzheimer's disease (AD) may be obtained by targeting multiple middle-age risk factors. However, as dementia is unlikely to be diagnosed for decades, short-term outcome measures are required. …”
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    The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease
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