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  1. 10801
    “…Parkinson's disease (PD) is the second most common neurodegenerative disease amongst the middle-aged and elderly populations. Several studies have confirmed that the microbiota-gut-brain axis (MGBA) serves a key role in the pathogenesis of PD. …”
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    Roles of α-synuclein in gastrointestinal microbiome dysbiosis-related Parkinson's disease progression
  2. 10802
    “…Data pertaining to epidemiology, risk factors, clinico-radiological features were analysed using percentage of total cases. RESULTS: Middle aged, diabetic males with recent COVID-19 infection were most affected. …”
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    COVID-19 associated rhino-orbital-cerebral mucormycosis: An observational study from Eastern India, with special emphasis on neurological spectrum
  3. 10803
    “…While frailty showed a linear increase with age and was greater in females than in males, social vulnerability was higher in young adults and elders compared to middle aged and older adults, and in males than females. …”
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    Identifying Frail Populations for Disease Risk Prediction and Intervention Planning in the Covid-19 Era: A Focus on Social Isolation and Vulnerability
  4. 10804
    “…The incidence of adverse transfusion reactions in middle-aged and elderly patients was relatively high, especially for those over 50 yr old, with an adverse reaction of 135, for example, the proportion reached 42.45%. …”
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    Analysis of Adverse Reactions of Blood Transfusion and Discussion of Influencing Factors in Linyi Area from 2013 To 2020
  5. 10805
    “…Multivariate logistic regression identified three statistically significant of risk factors: on a per-patient basis, being female (p=0.0018), having neuromuscular disease (p=0.0002), and receiving higher doses of IVIG per patient body weight (p<0.001), on a per-infusion basis, being female (p < 0.001), being adolescents to middle age (p < 0.001), and having neuromuscular disease (p < 0.001). …”
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    A Retrospective Observational Study of Adverse Reactions Associated With Intravenous Immunoglobulin Infusion
  6. 10806
    “…The objective of the current study was to explore the relationship between longitudinal change in body mass index (BMI) and reproductive hormones in middle-aged and elderly Chinese men. A cohort study was conducted in a rural area of China. …”
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    Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study
  7. 10807
    “…Age-stratified analysis indicated that suicide rates increased in younger (<25) and decreased in the middle age group (25–64 years). In older age groups (≥65), an immediate rate decrease was observed followed by a sustained upward trend during the onset of the pandemic. …”
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    Suicide trends varied by age-subgroups during the COVID-19 pandemic in 2020 in Taiwan
  8. 10808
    “…METHODS: This observational cohort study was conducted within the Multisite AIDS Cohort Study (MACS) and was designed to explore resiliencies to explain patterns of health and illness among middle-aged and older sexual minority men. To be eligible, a participant had to be an active participant in the MACS, be at least 40 years of age as of April 1, 2016, and report any sex with another man since enrollment in the MACS. …”
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    Understanding Patterns of Healthy Aging Among Men Who Have Sex With Men: Protocol for an Observational Cohort Study
  9. 10809
    “…Generally, males reported lower rates of taste loss than did females and taste loss was highest in middle-aged groups. Thus, taste loss is a bona fide symptom COVID-19, meriting further research into the most appropriate direct methods to measure it and its underlying mechanisms.…”
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    Taste loss as a distinct symptom of COVID-19: A systematic review and meta-analysis
  10. 10810
    “…Tracheal neurilemmoma is a rare condition in adults that usually affects middle-aged people, but it can also occur in children. …”
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    Primary intratracheal neurilemmoma in a 10-year-old girl: A case report
  11. 10811
    “…Multivariate analysis revealed that, after adjustments for potentially confounding factors, high hs-CRP was independently associated with lower HGS (B = −2.25; 95% confidence interval = −4.49 to −0.02) in older adults with depression, but not in younger or middle-aged adults with depression. CONCLUSION: These findings suggest a significant correlation between physical functional decline and low-grade inflammation in older adults with depression.…”
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    Relationship between Handgrip Strength and Low-grade Inflammation in Older Adults with Depression
  12. 10812
    “…Conclusion  The results of the study showed that the disease was associated with the male gender, young and middle age, low socioeconomic status, rural background, pond bathing and O+ blood group.…”
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    Retroanalytical Study of Epidemiological Factors of Rhinosporidiosis
  13. 10813
    “…BACKGROUND: Chronic prostatitis is a common andrological disease, which brings many troubles to the lives of middle-aged and elderly male patients. With the increase of modern life pressure, the incidence of chronic prostatitis tends to younger, but its etiology and pathogenesis are not fully elucidated. …”
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    Efficacy of acupuncture combined with traditional Chinese medicine on chronic prostatitis: A protocol for systematic review and meta-analysis
  14. 10814
    “…Aged-related declines in cognition, especially working memory and executive function, begin in middle-age and these abilities are known to be mediated by the prefrontal cortex (PFC) and more specifically the dopamine (DA) system within the PFC. …”
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    The Effects of a Novel Non-catechol Dopamine Partial Agonist on Working Memory in the Aged Rhesus Monkey
  15. 10815
    “…Findings in the literature show that statins reduce coronary and cerebrovascular morbidity and mortality in middle-aged people, but their benefits in older adults are not as well-established, especially in primary prevention. …”
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    Statin Therapy in Very Old Patients: Lights and Shadows
  16. 10816
    “…Current literature suggests that the COVID-19 pandemic has impacted older adults’ lives in several ways, including the frequency of social interactions and change in various life habits (Lesbrasseur et al., 2021). Data from 42 middle-aged and older, long-term married or cohabitating dyads were collected as part of an ongoing study of everyday cognition and functioning among couples. …”
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    Dyadic Perceptions of COVID-19 Pandemic Impact on Everyday Life
  17. 10817
    “…METHODS: In this study, 200 middle-aged Wistar rats of both sexes were supplemented with nitrate or placebo in the drinking water throughout their remaining life and we studied longevity, biochemical markers of disease, vascular reactivity along with careful determination of the cause of death. …”
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    Effects of chronic dietary nitrate supplementation on longevity, vascular function and cancer incidence in rats
  18. 10818
    “…Most subjects were middle-aged (36–55 years old) (66.5%). Many subjects reported to have experienced reduced incomes (49.2%) or losses of income (22.4%), while 15.6% reported losing their job during the COVID-19 pandemic. …”
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    Knowledge, Attitude, Behavior, and Socioeconomic Conditions of People Living with HIV in Indonesia During the COVID-19 Pandemic: A Cross-Sectional Study
  19. 10819
    “…BACKGROUND: Rett syndrome is a complex genetic disorder with age-specific manifestations and over half of the patients surviving into middle age. However, little information about the phenotype of adult individuals with Rett syndrome is available, and mainly relies on questionnaires completed by caregivers. …”
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    Phenotypes in adult patients with Rett syndrome: results of a 13-year experience and insights into healthcare transition
  20. 10820
    “…In conclusion, we found that oral hypofunction was associated with targeted protein intake for sarcopenia and frailty prevention in middle-aged and older community-dwelling adults. Comprehensive evaluation of oral function with intervention in cases of hypofunction could inform clinicians to better prevent sarcopenia.…”
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    Relationship between Oral Hypofunction, and Protein Intake: A Cross-Sectional Study in Local Community-Dwelling Adults
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