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  1. 10981
    “…Moreover, mice devoid of exon 10 (E10+/−) on one allele were generated to investigate the effects of 1:1 balanced expression of 4R-/3R-tau protein, since equal amounts of 4R-/3R-tau protein are synthesized in human brain. Middle-aged E10−/− mice displayed sensorimotor disturbances in the rotarod when compared to age-matched E10+/− and wild-type mice, and their muscular grip strength was less than that of E10+/− mice. …”
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    Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
  2. 10982
    por Yayan, Josef
    Publicado 2014
    “…The FRS is used for middle-aged people; hence, its appropriateness has not been demonstrated to predict the likelihood of CAD occurrence in very elderly people. …”
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    Weak Prediction Power of the Framingham Risk Score for Coronary Artery Disease in Nonagenarians
  3. 10983
    “…OBJECTIVE(S): Osteoarthritis (OA) is globally one of the most common diseases from the middle age onwards. Cartilage is an avascular tissue therefore it cannot be repaired in the body. …”
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    The effect of high frequency electric field on enhancement of chondrogenesis in human adipose-derived stem cells
  4. 10984
    “…We concluded that serum FT3 levels, even within the normal range, were inversely associated with microalbuminuria in middle-aged and elderly Chinese adults. FT3 concentrations might play a role in the pathogenesis of microalbuminuria.…”
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    Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria
  5. 10985
    “…Here, a simulated multi-talker scenario was combined with electroencephalography to study scene analysis and allocation of attention in young and middle-aged adults. Sequences of short words (combinations of brief company names and stock-price values) from four talkers at different locations were simultaneously presented, and the detection of target names and the discrimination between critical target values were assessed. …”
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    Using auditory pre-information to solve the cocktail-party problem: electrophysiological evidence for age-specific differences
  6. 10986
    “…High ambient temperatures decrease blood pressure (BP) in young and middle aged adults and may lead to orthostatic hypotension, increasing the risk of falls in older adults. …”
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    Effect of a Brief Heat Exposure on Blood Pressure and Physical Performance of Older Women Living in the Community—A Pilot-Study
  7. 10987
    “…The task force places a high value on the timely treatment of younger and middle-aged subjects to prevent the long-term consequences of hypoandrogenism.…”
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    Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology
  8. 10988
    por Kim, Kwi Baek
    Publicado 2014
    “…[METHODS]: The subjects consisted of 16 middle-aged women with type 2 diabetes mellitus (T2DM), all of whom had no other complications. …”
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    Effect of different training mode on Interleukin-6 (IL-6) and C-reactive protein (CRP) in type 2 diabetes mellitus (T2DM) patients
  9. 10989
    “…In a third of the cells from old and middle-aged donors repair of X-ray induced DNA strand breaks was impaired despite up-regulation of DNA repair genes. …”
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    Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors
  10. 10990
    por Hitsumoto, Takashi, Shirai, Kohji
    Publicado 2015
    “…PATIENTS AND METHODS: We enrolled 258 metabolic syndrome patients who were middle-aged males without a history of cardiovascular events. …”
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    Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients
  11. 10991
    “…To test this hypothesis, we investigated the genome-wide methylation profile in 4 Chinese female centenarians and 4 middle-aged controls using methyl-DNA immunoprecipitation sequencing. 626 differentially methylated regions (DMRs) were observed between both groups. …”
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    A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes
  12. 10992
    “…There was a male preponderance with male:female ratio of 1.72:1; the middle-aged and elderly made up about 76.1% of cases. …”
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    Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011
  13. 10993
    “…In addition there was a strong quadratic relationship between age and dominance rank (p < 0.001), where middle-aged individuals were most likely to be dominant. …”
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    Dominance rank is associated with body condition in outdoor-living domestic horses (Equus caballus)
  14. 10994
    “…The values of SDNN, SDANN, and DC of women were lower than that of men in the young and middle‐aged groups, but age‐related decrease of DC in men was greater than that in women. …”
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    Influences of Age, Gender, and Circadian Rhythm on Deceleration Capacity in Subjects without Evident Heart Diseases
  15. 10995
    “…CONCLUSIONS: Young to middle-aged subjects with recognizable predisposing factors for aspiration and who report a history of recurrent pneumonia are at increased risk for DAB. …”
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    Diffuse aspiration bronchiolitis: analysis of 20 consecutive patients
  16. 10996
    “…CASE PRESENTATION: A middle-aged man receiving treatment for bile duct cancer presented with headache and nausea. …”
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    Abscess formation within a cerebellar metastasis: Case report and literature review
  17. 10997
    “…INTRODUCTION: Colonic lipomas are rare subepithelial benign tumors affecting mainly middle-aged women. They are usually asymptomatic and, hence, are discovered incidentally on autopsy, surgery, or colonoscopy. …”
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    Large ileocecal submucosal lipoma presenting as hematochezia, a case report and review of literature
  18. 10998
    “…Obstructive sleep apnea (OSA) is much more prevalent in older people than in middle-aged or young populations, and has been associated with cardiovascular disease. …”
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    Continuous Positive Airway Pressure Treatment Reduces Mortality in Elderly Patients with Moderate to Severe Obstructive Severe Sleep Apnea: A Cohort Study
  19. 10999
    “…AIMS: We present novel findings obtained by analysing high-resolution structural MRI scans of 48 twins; specifically, we aimed: i) to test the BW-SA association in a middle-aged adult sample; and ii) to assess whether either depression/anxiety disorders or intellectual quotient (IQ) influence the BW-SA link, using a monozygotic (MZ) twin design to separate environmental and genetic effects. …”
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    Birth Weight and Adult IQ, but Not Anxious-Depressive Psychopathology, Are Associated with Cortical Surface Area: A Study in Twins
  20. 11000
    “…However, the temporal stability and variability of the bacterial community in fecal samples remain unclear. In this study, middle-aged Japanese male and female volunteers (n = 5 each) without disease were recruited from the Sakura Diet Study. …”
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    Inter- and intra-individual variations in seasonal and daily stabilities of the human gut microbiota in Japanese
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