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  1. 11561
    “…The regions of reduced GMV in people with PCDS were similar between the middle-aged and older adults; whereas larger clusters with more extensive GMV-depleted regions were observed in ≥65-year-olds with PCDS. …”
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    Cerebellar-limbic neurocircuit is the novel biosignature of physio-cognitive decline syndrome
  2. 11562
    “…Osteoarthritis (OA) is a common joint disorder characterized by progressive articular cartilage degeneration and destruction and results in gradual disability among middle-aged and elderly patients. Our previous study demonstrated that depletion of nuclear factor erythroid 2-related factor 2 (Nrf2) exacerbated cartilage erosion in an OA model and that activation of the Nrf2 pathway could counter this process. …”
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    Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling
  3. 11563
    por Jiang, Lili, Qiao, Kaini, Li, Chunlin
    Publicado 2021
    “…RESULTS: We recruited two groups of healthy participants, including young adults and middle-aged participants, for a total of 60 datasets including rfMRI and intelligence as well as emotional intelligence to study how human brain functional criticalities at different spatial scales contribute to individual behaviors. …”
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    Distance-based functional criticality in the human brain: intelligence and emotional intelligence
  4. 11564
    “…Shift workers with access to workplace vending machines were significantly more likely to consume soft drinks at least weekly (p=0.003, OR=1.64, 95% CI 1.18 to 2.27). Middle-aged shift workers (p=0.012, OR=0.65, 95% CI 0.46 to 0.91) and those reporting insufficient break times at work (p=0.026, OR=0.69, 95% CI 0.49 to 0.96) were significantly less likely to be sufficiently active. …”
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    Adherence to dietary and physical activity guidelines among shift workers: associations with individual and work-related factors
  5. 11565
    “…The ORACLE Study is embedded within Generation R, a prospective population-based cohort study of children and their parents, and links this with the Rotterdam Study, a population-based study in middle-aged and elderly persons. The studies are based in Rotterdam, the Netherlands. …”
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    Design and overview of the Origins of Alzheimer’s Disease Across the Life course (ORACLE) study
  6. 11566
    “…We report the case of a middle-aged female skeleton from the cemetery of the church of San Biagio (Ravenna, Italy), dating back to the 17th–19th centuries, that shows signs of a complete craniotomy. …”
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    Autopsy or anatomical dissection: evidence of a craniotomy in a 17th–eighteenth century burial site (Ravenna, Italy)
  7. 11567
    “…Although most cases of jugular bulb diverticulum are asymptomatic, excessive pressure on the surrounding structures might cause various symptoms, most prominently vertigo, sensorineural hearing loss, or tinnitus. CASE REPORT: A middle-aged male who was referred to the Department of Neurology with a recurrent complaint of left-sided facial weakness associated with headache and vertigo for a period of 24 months. …”
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    Recurrent Facial Palsy Due to High Jugular Bulb Dehiscence
  8. 11568
    “…It most commonly presents in middle-aged males and due to its non-specific clinical presentation, the diagnosis is often delayed until advanced disease is already present. …”
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    Extensive pulmonary metastases in young boy with primary cardiac angiosarcoma: a case report
  9. 11569
    “…RESULTS: Overall, 69.5% of middle-aged and elderly Chinese had multimorbidity in 2015. …”
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    Medical costs and out-of-pocket expenditures associated with multimorbidity in China: quantile regression analysis
  10. 11570
    “…We also performed MTT, FACS, transfection, TUNEL, and Western blotting assays to define the role of BMP4 in cells. We found that middle-aged BMP4 transgenic mice exhibited impaired memory via the Morris water maze experiment. …”
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    BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
  11. 11571
    “…Reductions were higher for occupational vs. leisure time, young and old vs. middle-aged persons, previously more active vs. less active individuals, but similar between men and women. …”
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    A Pandemic within the Pandemic? Physical Activity Levels Substantially Decreased in Countries Affected by COVID-19
  12. 11572
    “…INTRODUCTION: Parkinson's disease (PD) is a chronic degenerative disease of the central nervous system common in middle-aged and elderly people, which has a serious impact on patients' cognitive and motor functions. …”
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    The Feasibility and Positive Effects of Wuqinxi Exercise on the Cognitive and Motor Functions of Patients with Parkinson's Disease: A Pilot Study
  13. 11573
    “…Although it often occurs in middle-aged and elderly individuals, it cannot be readily excluded in young people, even when serum immunofixation electrophoresis is negative. …”
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    Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits in a young woman: A case report
  14. 11574
    “…The aim of this pilot study was to monitor the effects of a three-local time-spaced injections regimen of HA in the treatment of AT in middle-aged runners combining for the first time viscoelastometric, biochemical, and functional methodologies with routine clinical examinations. …”
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    Treatment of Achilles Tendinopathy in Recreational Runners with Peritendinous Hyaluronic Acid Injections: A Viscoelastometric, Functional, and Biochemical Pilot Study
  15. 11575
    “…CASE PRESENTATION: We report a case of a middle-aged lady who presented with severe pain and morning stiffness over the small joints of the left hand for 3 months and painless deformity of the affected joints 1 year before. …”
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    More than meets the naked eye: an unusual psoriatic arthritis mimicry and the important role of dermoscopic examination
  16. 11576
    por Jaques, David A., Davenport, Andrew
    Publicado 2021
    “…Peridialytic SBP trends represent a continuum with serum Na variation being a major determinant while volume status has negligible influence. Middle-aged and overweight patients are particularly prone to SBP decline. …”
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    Serum sodium variation is a major determinant of peridialytic blood pressure trends in haemodialysis outpatients
  17. 11577
    “…In this large cohort of young and middle-aged men and women, smoking status based on both self-report and urinary cotinine level were independently associated with an increased incidence of bilateral HL. …”
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    Self-reported and cotinine-verified smoking and increased risk of incident hearing loss
  18. 11578
    “…CONCLUSIONS: Our findings suggest the potential use of digital technology in reducing disparity in depression correlated with socioeconomic status among middle-aged and aged individuals in developing countries. …”
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    Does digital technology reduce health disparity? Investigating difference of depression stemming from socioeconomic status among Chinese older adults
  19. 11579
    “…Multiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. …”
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    Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy
  20. 11580
    “…In this case report, we describe severe protein-calorie malnutrition as an etiology for hepatic steatosis in a middle-aged woman who presented with lethargy, low body mass index (15.8 kg/m(2)), abdominal distention and bilateral lower extremity edema, hyperammonemia, and hypoalbuminemia, 13 years after Roux-en-Y gastric bypass for morbid obesity. …”
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    Severe Protein-Calorie Malnutrition-Associated Hepatic Steatosis in a Woman Who Had Roux-en-Y Gastric Bypass for Morbid Obesity Thirteen Years Ago
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