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  1. 11661
    “…Three age groups (younger—middle-aged—older men) were compared regarding the variables described above. …”
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    Disordered eating symptoms in Austrian men of different ages in the context of fitness centers
  2. 11662
    “…BACKGROUND: Inequalities in access to hospice care is a source of considerable concern; white, middle-class, middle-aged patients with cancer have traditionally been over-represented in hospice populations. …”
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    Hospice care access inequalities: a systematic review and narrative synthesis
  3. 11663
    “…The relationship of behavior metrics was found in the middle age and males. CONCLUSION: Improving LS7 scores might do a favor to alleviate the pathology of AD in the preclinical stage, especially among the APOE ε4 allele non-carriers. …”
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    Association between Life’s Simple 7 and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study
  4. 11664
    “…BACKGROUND: The cognitive function of people with diabetes has gained an increasing interest in recent years, and this study focuses on exploring the relationship between undiagnosed diabetes and cognitive function among the middle-aged and elderly people in China. METHODS: The data came from the China Health and Retirement Longitudinal Study (CHARLS) which was conducted between July and October 2015. 9855 subjects were enrolled in the study. …”
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    The association between undiagnosed diabetes and cognitive function: findings from the China health and retirement longitudinal study
  5. 11665
    “…Chi-square test analysis showed that compared with patients with viral encephalitis, patients with neurosyphilis mainly developed in middle-aged and elderly people (p < 0.001), were more likely to have temporal epileptiform discharges (p < 0.001), and less likely to have status epilepticus (SE) (p = 0.029). …”
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    Comparison of Electroencephalography in Patients With Seizures Caused by Neurosyphilis and Viral Encephalitis
  6. 11666
    “…The dermal thickness on zygoma and submandibular in young women was significantly higher than in middle age and old women (P < 0.05). Overall, with the increase of age, the thickness of facial skin decreased in women, mainly in the forehead, glabella, zygoma, and submandibular. …”
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    Application of high-frequency ultrasound to assess facial skin thickness in association with gender, age, and BMI in healthy adults
  7. 11667
    “…RESULTS: ACC was more common in the middle-aged and elderly and peaked at approximately 60 years. …”
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    Imaging and Clinicopathological Features of Acinar Cell Carcinoma
  8. 11668
    “…Alzheimer’s disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle age and later and is frequently accompanied by cerebrovascular pathology at death. …”
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    FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease
  9. 11669
    “…Conclusions: Non-use of condoms is a common STI risk behaviour among heterosexually-active single people in Germany and so needs promoting from sexual debut throughout the life course, regardless of relationship type and age, but particularly among middle-aged and older people.…”
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    Factors associated with non-use of condoms among heterosexually-active single people in Germany: Results from the first representative, population-based German health and sexuality survey (GeSiD)
  10. 11670
    “…Globally, over 16 million patients with RVO were found in the middle-aged population. Paeoniflorin (PF), a monomer of Taohong Siwu decoction, was reported to exhibit many pharmacological activities including anti-inflammatory, antioxidant, cardioprotective, and neuroprotective effects. …”
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    Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway
  11. 11671
    “…The relative risk was higher in young and middle-aged individuals than in the older population. …”
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    Obesity Fact Sheet in Korea, 2021: Trends in Obesity Prevalence and Obesity-Related Comorbidity Incidence Stratified by Age from 2009 to 2019
  12. 11672
    “…In younger women, Δ age was larger than in middle‐aged and older women. This effect was particularly evident when considering the interaction of women's age with assessor gender and ethnicity, independently and together, on Δ age. …”
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    Differences between perceived age and chronological age in women: A multi‐ethnic and multi‐centre study
  13. 11673
    “…Even in a population where the majority of test-positives were not hospitalized, a considerable proportion experiences symptoms up to 12 months after infection. Being female or middle-aged increases risks.…”
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    A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark
  14. 11674
    “…Using electrophysiological, histochemical, and biochemical approaches, we have examined if glutamatergic synaptic transmission in DA neurons in the SNc and in the adjacent ventral tegmental area (VTA) was altered in middle‐aged (10–12 months old) mice with the hG2019S point mutation (G2019S) in the leucine‐rich repeat kinase 2 (LRRK2) gene. …”
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    LRRK2‐G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons
  15. 11675
    “…CONCLUSION: Within this sample of middle‐aged and older adults, a “high micronutrient and fibre” dietary pattern was associated with reduced risk of periodontal disease.…”
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    Associations between self‐reported periodontal disease and nutrient intakes and nutrient‐based dietary patterns in the UK Biobank
  16. 11676
    “…CONCLUSION: Melanoma causes heavy economic burdens on patients in Hunan, such that the median spending is close to 60% of the averagely annual disposable income. Middle-aged men patients with melanoma on the limbs present the highest financial burden of melanoma.…”
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    Spending and Hospital Stay for Melanoma in Hunan, China
  17. 11677
    “…METHODS: A single center cross-sectional study was conducted, consisting of 521 middle-aged subjects of Maltese-Caucasian ethnicity. …”
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    Reduced leukocyte mitochondrial copy number in metabolic syndrome and metabolically healthy obesity
  18. 11678
    “…With adjustments for the age-dependent sensitivities to radiation exposure, it was extrapolated that middle-aged people who entered the city on the day of the bombing were exposed to higher levels of residual radiation than younger people.…”
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    Solid cancer mortality risk among a cohort of Hiroshima early entrants after the atomic bombing, 1970–2010: implications regarding health effects of residual radiation
  19. 11679
    “…By contrast, DAF‐2 depletion in the muscle of middle‐age animals improved their motility independently of DAF‐16/FOXO but required UNC‐120/SRF. …”
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    DAF‐2/insulin IGF‐1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues
  20. 11680
    “…Given their role as intercellular communicators and potential biomarkers of disease, we explored whether circulating EVs may be markers of mortality in a prospective, racially, and socioeconomically diverse middle-aged cohort. We isolated plasma EVs from 76 individuals (mean age = 59.6 years) who died within a 5 year period and 76 surviving individuals matched by age, race, and poverty status. …”
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    Association of extracellular vesicle inflammatory proteins and mortality
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