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  1. 12441
    “…Our previous work identified a specific critical period (CP) of decline in NSPC activity and function during middle age (13–15 months), and revealed the reduced expression of the redox‐sensitive transcription factor, NRF2, as a key mediator of this process. …”
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    Enhanced NRF2 expression mitigates the decline in neural stem cell function during aging
  2. 12442
    “…CONCLUSION: Our findings showed that male patients with middle age and comorbidity disease were more susceptible to the COVID-19 infection. …”
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    Alkaline phosphatase and score of HRCT as indicators for predicting the severity of COVID-19
  3. 12443
    “…The present study is aimed at determining the effects of intensity-modified recreational volleyball training on health markers and physical fitness in healthy middle-aged men. Thirty-four healthy untrained men aged 25–55 years were randomized to either a modified recreational volleyball group (MRV, n = 17) or a recreational volleyball group (RV, n = 17). …”
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    Intensity-Modified Recreational Volleyball Training Improves Health Markers and Physical Fitness in 25–55-Year-Old Men
  4. 12444
    “…Stroke is a common critical disease occurring in middle-aged and elderly individuals, and is characterized by high morbidity, lethality and mortality. …”
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    Advancement in research on the role of the transient receptor potential vanilloid channel in cerebral ischemic injury (Review)
  5. 12445
    “…Negative effects of maternal continuous smoking during pregnancy include all substance use and reach up to offspring’s middle age.…”
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    Maternal smoking trajectory during pregnancy predicts offspring’s smoking and substance use – The Northern Finland birth cohort 1966 study
  6. 12446
    “…The participants are from the German Family Panel, which is a longitudinal survey of younger and middle-aged adults with eight follow-up waves. We exploited within-person (or fixed-effect) regression models, which concentrated an individual’s variation over time (i.e., whether changes in parental investment frequencies are associated with subsequent changes in adult children’s fertility intentions). …”
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    Does Parental Investment Shape Adult Children’s Fertility Intentions? Findings From a German Family Panel
  7. 12447
    “…We aim to determine the sleep correlates of age-related brain loss in a sample of middle-aged to older males with obstructive sleep apnea (OSA). …”
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    Cognitive and Neuroimaging Correlates of the Insomnia Severity Index in Obstructive Sleep Apnea: A Pilot-Study
  8. 12448
    “…We administered thyroxine to middle-aged (13 to 14 months) male and female mice to model hyperthyroidism and TH-lowering drugs propylthiouracil (PTU) and methimazole, to induce hypothyroidism. …”
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    Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and Compensatory Brain Changes
  9. 12449
    “…Participants in the studies were healthy, middle-aged adults, older adults and clinical patients. …”
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    Blood Flow Restriction Training: To Adjust or Not Adjust the Cuff Pressure Over an Intervention Period?
  10. 12450
    “…Participants were 53% women and middle-aged (47 ± 12 years). The majority (59%) had been in treatment for at least 1 year at study enrollment. …”
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    Treatment Outcomes Among Black Adults Receiving Medication for Opioid Use Disorder
  11. 12451
    por Li, Xin, Ren, Sufen, Gu, Fangqiu
    Publicado 2021
    “…Stroke is a major disease that seriously endangers the lives and health of middle-aged and elderly people in our country, but its implementation of secondary prevention needs to be improved urgently. …”
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    Medical Internet of Things to Realize Elderly Stroke Prevention and Nursing Management
  12. 12452
    “…The epicardial adipose tissue volume was significantly increased in middle-aged and older women. The epicardial adipose tissue volume was significantly and negatively correlated to peak cardiac output and peak oxygen uptake, regardless of age and sex; furthermore, epicardial adipose tissue showed a strong negative correlation with peak heart rate. …”
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    Epicardial adipose tissue is associated with cardiorespiratory fitness and hemodynamics among Japanese individuals of various ages and of both sexes
  13. 12453
    “…Moreover, higher total MRI CSVD burden was associated with the overall cognitive impairment among middle-aged and elderly Chinese adults.…”
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    Higher Total Cerebral Small Vessel Disease Burden Was Associated With Mild Cognitive Impairment and Overall Cognitive Dysfunction: A Propensity Score-Matched Case–Control Study
  14. 12454
    “…We analyzed the cardiac function of three different age groups of female Rage-/- and C57BL/6N (WT) mice: 2.5- (Young), 12- (Middle-age, MA) and 21-months (Old) old. While aging, Rage-/- mice displayed an increase in left ventricle (LV) dimensions compared to age-matched WT animals, with the main differences observed in the MA groups. …”
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    Soluble Receptor for Advanced Glycation End-products regulates age-associated Cardiac Fibrosis
  15. 12455
    “…OBJECTIVE: This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection. …”
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    Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men
  16. 12456
    “…CONCLUSIONS: Neoadjuvant DOX is an effective and feasible regimen and might represent an option for young and middle-aged patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma.…”
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    Efficacy of Neoadjuvant Chemotherapy DOX and XELOX Regimens for Patients with Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
  17. 12457
    “…It does this by examining time-use patterns and SRH among middle-age adults in the United States distinguished by race/ethnicity and with additional attention to differences in responses based on language of interview for Hispanics. …”
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    What do time-use patterns tell us about the validity of self-reported health?
  18. 12458
    “…CONCLUSION: Higher HDL-C levels were independently associated with accelerated GFR loss in a general middle-aged nondiabetic population.…”
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    Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population
  19. 12459
    “…BACKGROUND: The investigation of middle-aged women’s mental and physical health measures should be focused on menopause-a predictable physiological phenomenon in their lives. …”
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    Factors Associated with Delayed Menopause in Iran: Findings from Fasa Cohort Study, a Branch of Persian Cohort Study
  20. 12460
    “…In this study, we investigated a novel pharmacological strategy based on inhibition of the adenosine A(2A) receptor (A(2A)R) in middle aged C57BL/6 mice prone to early onset ARHL. …”
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    Istradefylline Mitigates Age-Related Hearing Loss in C57BL/6J Mice
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