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  1. 12801
    “…Our study investigates the development of social inequalities in multimorbidity among the middle-aged and older working population. Special attention is paid to whether differing time trends between socio-economic status (SES) groups have taken place, increasing or decreasing inequalities in multimorbidity. …”
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    Widening inequalities in multimorbidity? Time trends among the working population between 2005 and 2015 based on German health insurance data
  2. 12802
    “…BACKGROUND: Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Yet, it remains elusive if such biomarkers are associated with aging-related outcomes earlier in life when individuals begin to diverge in aging trajectories. …”
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    The epigenetic clock and pubertal, neuroendocrine, psychiatric, and cognitive outcomes in adolescents
  3. 12803
    “…We found that compared to PEDF levels in young and middle-aged control subjects, PEDF levels were reduced in old-aged controls and even more so in AD patients. …”
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    Pigment Epithelium-Derived Factor Plays a Role in Alzheimer’s Disease by Negatively Regulating Aβ42
  4. 12804
    “…CONCLUSIONS: Our findings reveal for the first time that anticoagulation therapy, including novel oral anticoagulants, had no preventive effect against cerebral infarctions associated with adenomyosis in a middle-aged woman. Although pseudomenopause treatment temporarily prevented recurrence, resection of the adenomyosis might be the most effective therapy in these cases.…”
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    “Recurrent multiple cerebral infarctions related to the progression of adenomyosis: a case report”
  5. 12805
    “…To this end, biopsies were collected from sun-exposed (outer arm, n = 45) and sun-protected (inner arm, n = 45) skin from fair-skinned (phototype II/III) healthy female volunteers of three age groups: young, 18–25 years, middle age, 40–50 years and aged, > 70 years. Strict inclusion criteria were used for photoageing scoring and for chronological ageing. …”
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    Identification of chronological and photoageing-associated microRNAs in human skin
  6. 12806
    “…NSC EVs improved cellular, tissue, and functional outcomes in middle-aged rodents, whereas MSC EVs were less effective. …”
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    Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model
  7. 12807
    “…OBJECTIVE: Data on dietary patterns in relation to the risk of metabolic syndrome (MetS) in a middle-aged Chinese population are sparse. The present study was performed to determine the major dietary patterns among a population aged 45–59 years and to evaluate their associations with MetS risk in China. …”
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    Dietary patterns and the risk of metabolic syndrome in Chinese adults: a population-based cross-sectional study
  8. 12808
    “…CONCLUSIONS: Among middle-aged outpatients evaluated due to suspected myocardial ischaemia, previously undiagnosed COPD is at least as common as reversible myocardial ischaemia and the presenting symptoms do not differentiate between these entities. …”
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    High prevalence of undiagnosed COPD among patients evaluated for suspected myocardial ischaemia
  9. 12809
    “…RESEARCH DESIGN AND METHODS: Participants included 1,318 mobile phone users drawn from a national probability sample of Japanese middle-aged (65% aged 40–64 years) and older adults (35% aged 65 years or older) in 2011. …”
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    Uses and Gratifications Sought From Mobile Phones and Loneliness Among Japanese Midlife and Older Adults: A Mediation Analysis
  10. 12810
    “…CASE PRESENTATION: A middle-aged male, diagnosed with PD, received dopamine replacement with piribedil. …”
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    Hypotension and bradycardia, a serious adverse effect of piribedil, a case report and literature review
  11. 12811
    “…There were no significant associations between sleep duration and hypertension in the total sample, among middle-aged adults (45–59 years) or older adults (60–79 years). …”
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    Relationship between sleep duration and hypertension in northeast China: a cross-sectional study
  12. 12812
    “…OBJECTIVE: Obesity often emerges in middle age, increasing risk for metabolic disorders. …”
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    Regular exposure to non-burning ultraviolet radiation reduces signs of non-alcoholic fatty liver disease in mature adult mice fed a high fat diet: results of a pilot study
  13. 12813
    “…OBJECTIVE: Nonspecific chronic low back pain (CLBP) is a frequent medical condition among middle-aged and older adults. Its detrimental consequences for functional ability and quality of life are well known. …”
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    Pain Intensity, Disability, and Quality of Life in Patients with Chronic Low Back Pain: Does Age Matter?
  14. 12814
    “…HTN patients manifested faster decline of diffusion parameters but also reached a plateau earlier, with highest between-group differences noted in the middle-aged subgroup. Healthy and hypertensive participants have different brain aging patterns. …”
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    Aging and Hypertension – Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging
  15. 12815
    “…Unexpectedly, the thickness of the myelin sheath was reduced in middle-aged (>12 months old), but not young adult FbCtgf KO mice. …”
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    Genetic Elimination of Connective Tissue Growth Factor in the Forebrain Affects Subplate Neurons in the Cortex and Oligodendrocytes in the Underlying White Matter
  16. 12816
    “…Thus, we aimed to develop an FI using UK Biobank data, a cohort study of 500,000 middle-aged and older adults. METHODS: An FI was calculated using 49 self-reported questionnaire items on traits covering health, presence of diseases and disabilities, and mental well-being, according to standard protocol. …”
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    A Frailty Index for UK Biobank Participants
  17. 12817
    “…Additionally, we analyzed the microarchitecture of tibiae from young, middle-aged and aged GPRC6A KO mice and wildtype (WT) littermates. …”
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    Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice
  18. 12818
    “…CASE SUMMARY: In the current report, we describe two middle-age patients who were originally diagnosed with diabetes mellitus with no classical symptoms of lung cancer. …”
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    Small cell lung cancer starting with diabetes mellitus: Two case reports and literature review
  19. 12819
    “…To reduce the stroke burden in China, target BP goals must be established for adults, with different targets for the middle-aged and the elderly segments of the population. …”
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    Association of Blood Pressure With Stroke Risk, Stratified by Age and Stroke Type, in a Low-Income Population in China: A 27-Year Prospective Cohort Study
  20. 12820
    por Veltri, Charles, Grundmann, Oliver
    Publicado 2019
    “…While pure Kratom is primarily used by day laborers and misused in conjunction with cough medicine by youth in Southeast Asia, a majority of users in the United States is middle-aged, has at least middle income, private health insurance, and completed some college. …”
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    Current perspectives on the impact of Kratom use
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