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  1. 12881
    “…However, the value of screening middle aged and older adults for these levels hinges largely on the ability of interventions in screen-positive people to lead to a reduced incidence of atrial fibrillation and its complications.…”
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    Incidence of Atrial Fibrillation in Persons with Very High Serum Levels of N-Terminal Pro-B-Type Natriuretic Peptide: The Multi-Ethnic Study of Atherosclerosis
  2. 12882
    “…The aim of this work was the evaluation of deaths associated with SARS-CoV‑2 of persons of younger or middle age (up to 50 years) at the Institute of Legal Medicine in Hamburg, Germany, with presentation of frequency, comorbidities and disease courses. …”
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    SARS-CoV-2-assoziierte Todesfälle von erwachsenen Personen bis 50 Jahre: Eine retrospektive Auswertung der COVID-19-assoziierten Todesfälle im Jahr 2020 im Institut für Rechtsmedizin Hamburg, Deutschland
  3. 12883
    por Yuan, Shi-Yang, Xie, Kai-Fan, Yang, Jian
    Publicado 2021
    “…CASE SUMMARY: During the summer, a middle-aged man and an elderly man were diagnosed with heat stroke, rhabdomyolysis, and acute renal impairment. …”
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    Intramuscular hematoma in rhabdomyolysis patients treated with low-molecular-weight heparin: Report of two cases
  4. 12884
    “…OBJECTIVE: Compelling evidence suggests that childhood adversities are associated with an increased risk of hypertension in middle age and old age. The link between childhood adversities and blood pressure in youth is less clear. …”
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    Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men
  5. 12885
    “…We present a case report of a previously healthy, middle-aged individual from the malaria-endemic area who suffered SARS-CoV-2 and Plasmodium falciparum co-infection. …”
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    Insights into Plasmodium and SARS-CoV-2 co-infection driven neurological manifestations
  6. 12886
    “…Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medical inspection at Tri-Service General Hospital (TSGH) in Taiwan, had been enrolled in this study. …”
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    Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study
  7. 12887
    “…Conclusion: Limited levels of health literacy were significantly higher among middle-aged women, among those living in rural areas, among women who rated their health as poor or very poor, and who exhibited more negative patterns of reproductive health behavior, indicating the need for implementation of prevention programs and strategies with the aim of increasing the level of health literacy.…”
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    Relationship Between Socio-Demographic Characteristics, Reproductive Health Behaviors, and Health Literacy of Women in Serbia
  8. 12888
    “…Attention of clinicians and researchers for subthreshold borderline personality pathology is needed in middle-aged and older persons.…”
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    Impact of borderline personality disorder traits on the association between age and health-related quality of life: A cohort study in the general population
  9. 12889
    “…Using suicide as our distal measure of mental health further implies that public health programming intended to address the drivers of self-destructive behavior should reduce barriers to intimacy in the middle-aged populations.…”
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    Sildenafil and suicide in Sweden
  10. 12890
    “…OBJECTIVES: Studies on coronavirus disease 2019 (COVID-19) usually focus on middle-aged and older adults. However, younger patients may present with severe COVID-19 with potentially fatal outcomes. …”
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    COVID-19: Autopsy findings in six patients between 26 and 46 years of age
  11. 12891
    “…RESULTS: Adjusted for covariates, young adults who were overweight-fat (OR = 1.18, p < .01), middle-aged adults who were underweight-skinny (OR = 1.32, p < .05), and older adults who were healthy weight-fat (OR = 1.19, p < .05) were more likely to have suicidal ideation than their healthy weight-normal counterparts. …”
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    Body mass index, subjective body shape, and suicidal ideation among community-dwelling Korean adults
  12. 12892
    “…CONCLUSIONS: Although the associations of cigarette smoking with alterations in BP are small, the greater PP observed in consistent smokers may contribute in part to the higher cardiovascular disease risk observed in this group because PP is a strong predictor of cardiovascular disease risk after middle age.…”
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    Cigarette Smoking and Longitudinal Associations With Blood Pressure: The CARDIA Study
  13. 12893
    “…CASE PRESENTATION: A middle-aged female patient with brain metastases was evaluated using hybrid PET/MRI with (18)F-FACBC before and after stereotactic radiotherapy, and at suspicion of recurrence. …”
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    (18)F-FACBC PET/MRI in the evaluation of human brain metastases: a case report
  14. 12894
    “…Twenty-six healthy middle-aged to old adults (M age = 61 years; range 46–79 years; females n = 13) participated. …”
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    Influence of visual feedback, hand dominance and sex on individuated finger movements
  15. 12895
    “…The results show that spreading depression resulted in a hyperemic blood flow response that was dramatically reduced (24% in amplitude, 70% in area) in both middle‐aged and aged CVN‐AD mice compared to C57Bl/6 age‐matched controls. …”
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    CVN‐AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls
  16. 12896
    “…Those with youngest age-of-onset or longer duration of diabetes had more rapid declines in eGFR compared to those diagnosed at middle age or those with shorter duration of diabetes.…”
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    Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
  17. 12897
    “…Levels of the dendritic marker MAP2 in the cortex were higher in irradiated than sham-irradiated mice at middle age, which might be part of a compensatory response. …”
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    Associations between lipids in selected brain regions, plasma miRNA, and behavioral and cognitive measures following (28)Si ion irradiation
  18. 12898
    “…BACKGROUND: Succinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory and metabolic disorders in middle-aged adults. The relationship between plasma succinate levels and cardiovascular disease (CVD) risk in young adults is unknown. …”
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    Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults
  19. 12899
    “…This report involves the case of a middle-aged man who suffered from CIP, had repeated painless fractures, and developed bone and joint destruction. …”
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    Case Report: Mutant SCN9A Susceptible to Charcot Neuroarthropathy in a Patient With Congenital Insensitivity to Pain
  20. 12900
    “…Here, utilizing a rat model of transitional menopause, we administered either E2, progesterone, levonorgestrel, or combinations of E2 with progesterone or with levonorgestrel daily to follicle-depleted, middle-aged rats. A battery of assessments, including spatial memory, anxiety-like behaviors, and depressive-like behaviors, as well as endocrine status and ovarian follicle complement, were evaluated. …”
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    Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause
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