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  1. 13721
    “…CONCLUSIONS: Our large‐scale cohort study of young‐ to middle‐aged men and women demonstrated a significant association between long working hours and an increased risk of incident CKD.…”
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    A longitudinal study of working hours and chronic kidney disease in healthy workers: The Kangbuk Samsung Health Study
  2. 13722
    por Stieger, Mirjam, Lachman, Margie E.
    Publicado 2021
    “…We examined cognitive activities and cognition in a national sample of 2,130 community-dwelling middle-aged and older adults from the Midlife in the United States longitudinal study. …”
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    Increases in Cognitive Activity Reduce Aging-Related Declines in Executive Functioning
  3. 13723
    “…CONCLUSION: The newly developed age- and sex-specific continuous MS score for the Korean population is an independent predictor of ischemic stroke and MI in Korean middle-aged adults even after adjusting for confounding factors.…”
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    Metabolic Syndrome Severity Score for Predicting Cardiovascular Events: A Nationwide Population-Based Study from Korea
  4. 13724
    “…OBJECTIVE: The aim of the study was to show whether WF performed for 8 days may be a threat to the health and/or life of people undergoing this practice. METHODS: Twelve middle-aged men participated in the study. During the 8-day WF, the subjects ate no food except for drinking mineral water. …”
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    Is Water-Only Fasting Safe?
  5. 13725
    “…METHODS AND PROCEDURES: In a general population cohort study (n = 12,150) with longitudinal follow up from childhood to middle age, Cox proportional hazard models were used to study the associations between childhood neurodevelopmental markers (Rutter B scale and IQ) and premature all-cause mortality. …”
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    Childhood neurodevelopmental markers and risk of premature mortality: Follow-up to age 60–65 years in the Aberdeen Children of the 1950s study
  6. 13726
    “…CONCLUSION: There is a marked step-up in TC at age 50 years for Vietnamese women that cannot be explained by their age, or by their body fatness or its distribution, or by their socio-demographic characteristics or behavioural factors, and which results in greater mean levels of TC for middle-aged women than for their male counterparts in Vietnam.…”
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    Sex differences in total cholesterol of Vietnamese adults
  7. 13727
    “…Conclusions: HFRS in Shandong Province has shown seasonal and spatial clustering characteristics. Middle-aged and elderly farmers are a high-risk population. …”
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    Epidemiological Characteristics and Regional Risk Prediction of Hemorrhagic Fever with Renal Syndrome in Shandong Province, China
  8. 13728
    “…Performances differed between young (20–39 years), middle-aged (40–59 years), and elderly (60–79 years) participants. …”
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    Writing with the Eyes: The Effect of Age on Eye-Tracking Performance in Non-Disabled Adults and a Comparison with Bimanual Typing
  9. 13729
    “…OBJECTIVE: Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, is a common autoimmune thyroiditis, which mostly occurs in young and middle-aged women. It can be manifested as hyperthyroidism in the early stage; hypothyroidism may appear with the progression of the disease. …”
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    Integrative Analyses of Genes Associated with Hashimoto's Thyroiditis
  10. 13730
    por Pan, Yuanxing, Lin, Yunfei, Mi, Chuan
    Publicado 2021
    “…Cox multivariate regression analysis revealed that endocrine therapy, number of metastatic lymph nodes, visceral metastasis, number of bone metastasis sites, and c-erbB-2 expression were independent prognostic factors. CONCLUSIONS: Middle-aged and elderly patients with breast cancer, mainly aged 40–60 years old, are prone to bone metastasis. …”
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    Clinicopathological characteristics and prognostic risk factors of breast cancer patients with bone metastasis
  11. 13731
    “…Osteoarthritis (OA) is mainly manifested by joint pain, stiffness and mobility disorder, which is the main cause of pain and disability in middle-aged and elderly people. In this study, we aimed to explore the role and mechanism of 8-Methoxypsoralen (8-MOP) in the OA model both in vitro and in vivo. …”
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    8-Methoxypsoralen has Anti-inflammatory and Antioxidant Roles in Osteoarthritis Through SIRT1/NF-κB Pathway
  12. 13732
    “…The rise of this particular viral sensation was at the detriment of the Achilles tendons of three middle aged gentlemen on who we base our case series. …”
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    Achilles' tendon rupture dancing the ‘Jerusalema’ – A case series
  13. 13733
    por Sugihara, Kazunobu, Tanito, Masaki
    Publicado 2021
    “…IOP(RBT) tended to be higher than IOP(GAT) in young subjects, but this stabilized in middle age and became higher in older subjects.…”
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    Different Effects of Aging on Intraocular Pressures Measured by Three Different Tonometers
  14. 13734
    “…Clinicians are recommended to be alert to the increased likelihood of developing ADs, particularly for middle-aged women.…”
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    Risk of Autoimmune Diseases in Patients With Interstitial Cystitis/Bladder Pain Syndrome: A Nationwide Population-Based Study in Taiwan
  15. 13735
    “…A previous study demonstrated that middle-aged (5-6 months of age) senescence-accelerated mouse prone 8 (SAMP8) mice can be used as animal models of mild cognitive impairment (MCI). …”
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    An enriched environment delays the progression from mild cognitive impairment to Alzheimer's disease in senescence-accelerated mouse prone 8 mice
  16. 13736
    “…The proportion of important drugs among all antimicrobial drugs used in a clinic was high in recently established clinics with middle-aged and older directors.…”
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    Current Status of Antimicrobial Drug Use in Japanese Companion Animal Clinics and the Factors Associated With Their Use
  17. 13737
    “…Nasal polyps typically affect middle-aged and elderly patients, average age at diagnosis is 40 to 60, and men are affected more commonly than women. …”
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    Recorded prevalence of nasal polyps increases with age
  18. 13738
    “…In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population. METHODS: This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. …”
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    Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults
  19. 13739
    “…We addressed this gap by estimating how a validated measure of brain health relates to changes in BP over a period of 12 years. Methods: Middle-age (44–46 years at baseline, n = 335, 52% female) and older-age (60–64 years, n = 351, 46% female) cognitively intact individuals underwent up to four brain scans. …”
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    Optimal Blood Pressure Keeps Our Brains Younger
  20. 13740
    “…In our sample of primarily middle-aged and older adults with chronic pain, medical cannabis was associated with reduced pain intensity/inference, lower anxiety/depression, and improved sleep and quality of life.…”
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    Health Outcomes among Adults Initiating Medical Cannabis for Chronic Pain: A 3-month Prospective Study Incorporating Ecological Momentary Assessment (EMA)
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