“…Prostate cancer occurs in the prostatic epithelium and poses a threat to the health of middle-aged and older males. The objective of the present study was to explore the roles of microRNA (miRNA/miR)-130b in prostate cancer and potential molecular mechanisms in order to control the migration and invasion of prostate cancer. …”
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“…However, there is no prospective data confirming whether pulsatile stress in early life affect renal function in middle age. The authors performed a longitudinal analysis of 1738 participants aged 6–15 years at baseline, an ongoing Adolescent Prospective Cohort with a follow‐up of 30 years. …”
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“…This study aimed to investigate the chronic effects of green tea (GT) extract and resistance training (RT) on ambulatory and office blood pressure (BP), heart rate (HR), and rate‐pressure product (RPP) in a sample of Iranian women with high‐normal/stage 1 hypertension. Forty‐four middle‐aged sedentary women participated in this randomized, double‐blind, placebo‐controlled study. …”
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“…Declining physical function is an important hallmark of frailty, and we previously published that long term vitamin D insufficiency from young to middle-age leads to declines in endurance and gait disturbances. …”
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“…Herein, we evaluated the skeletal muscle characteristics of 54 nonagenarians and centenarians (mean age 98 years, range 90-110 years; 63% women) and 25 middle-aged individuals (mean age 54 years, range 40-59 years; 36% women) belonging to the Long Life Family Study (LLFS), an international, multicenter cohort of families with a clustering of longevity. …”
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“…The current study tested whether sleep duration alters the genetic and environmental contributions to why middle-aged and older adults vary on cognitive functioning. …”
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“…We examined BMI and WC in middle-aged women living with HIV (WLWH) and without HIV (HIV-) in relation to 10-year trajectories of NP in the Women’s Interagency HIV Study (WIHS). …”
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“…This study was performed to evaluate the intermediate-term clinical and radiological outcomes following a modified Broström procedure and arthroscopic debridement in middle-aged patients with combined medial gutter osteoarthritis and chronic lateral ankle instability. …”
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“…We found that the risk of alcohol consumption was higher in young and middle-aged men from low and middle socioeconomic status. …”
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“…METHODS: Cross-sectional study of 28,779 middle-age and older-age adults (45-85 years) in the baseline Canadian Longitudinal Study on Aging comprehensive cohort. …”
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“…Consistent moderate intensity (~10 m/min) treadmill exercise can reverse aging-related parkinsonian signs by 20 weeks in a 2-week on, 2-week off, regimen in previously sedentary advanced middle-aged rats. In this study, we initiated treadmill exercise in sedentary 18-month-old male rats to address two questions: (1) if a rest period not longer than 1-week off exercise, with 15 exercise sessions per month, could attenuate parkinsonian signs within 2 months after exercise initiation, and the associated impact on heart rate (HR) and mean arterial pressure (MAP) and (2) if continuation of this regimen, up to 20 weeks, will be associated with continual prevention of parkinsonian signs. …”
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“…CONCLUSION: Study results suggest that while obesity incidence is higher among certain age groups in both genders, middle-aged women, and men in all tertiles of overweight category are at highest risk and may be the optimum population to target for weight loss interventions. …”
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“…Younger (YA; n = 136, 18-35 years), middle-aged (MA; n = 126, 36-54 years), and older (OA; n = 171, 55-88 years) adults completed questionnaires assessing self-reported executive functions (EF) and perceived loneliness using the BRIEF-A and UCLA Loneliness scale respectively. …”
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“…Methods: We included 434,584 middle-aged and older men and women who were free of cancer at recruitment of the UK Biobank (2006–2010). …”
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“…Common themes we found around patients who had died by suicide included middle aged men who lived alone, with a diagnosis of adjustment disorder, recent financial stress and relationship breakdown, upcoming court case, abusing drugs or alcohol. …”
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“…Among this high H. pylori prevalent, middle-aged population, the majority of discrepant cases between serology and histology were due to false positive-serology, rather than false-negative histology. …”
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“…Shorter TL was associated with dietary total PCBs (SD of T/S ratio/(ng/day) = −0.30 × 10(−7); 95% CI, −0.55 × 10(−7) to −0.06 × 10(−7)), dioxin-like PCBs (DL-PCBs) (SD of T/S ratio/(pg WHO TEQ (Toxic Equivalents)/day) = −6.17 × 10(−7); 95% CI, −11.30 × 10(−7) to −1.03 × 10(−7)), and total TEQ exposure (SD of T/S ratio/(pg WHO TEQ/day) = −5.02 × 10(−7); 95% CI, −9.44 × 10(−7) to −0.61 × 10(−7)), but not with dioxins (SD of T/S ratio/(pg WHO TEQ/day) = −13.90 × 10(−7); 95% CI, −37.70 × 10(−7) to 9.79 × 10(−7)). In this sample of middle-aged and older Spanish adults, dietary exposure to total PCBs and DL-PCBs alone and together with dioxins was associated with shorter TL. …”
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“…Further studies are needed to fully establish a causal relationship between IBD and ASCVD, characterize the mechanisms underlying these associations, and identify tailored opportunities for ASCVD prevention in young and middle-aged adults with IBD.…”
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“…Data were analysed using independent samples t-tests and multiple regression. RESULTS: Middle-aged people reported a less strong social network and more loneliness, anxiety and depression than younger people. …”
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“…However, while there is extensive literature on internet-based treatments in younger to middle-aged adults, research on older individuals is lacking. …”
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