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  1. 14041
    “…OBJECTIVE: The aim of this study is to determine the effects of a 2-year digital lifestyle intervention on AD risk among at-risk middle-aged and older adults (45-75 years) compared with a health education control. …”
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    Intervention for a Digital, Cognitive, Multi-Domain Alzheimer Risk Velocity Study: Protocol for a Randomized Controlled Trial
  2. 14042
    “…The results may be of interest for both clinicians and other stakeholders with respect to informing measures targeting increasing physical activity and controlling weight, especially among middle-aged people. Additionally, the information on the established trajectories may give individuals motivation to change their health behaviour.…”
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    Concurrent changes in physical activity and body mass index among 66 852 public sector employees over a 16-year follow-up: multitrajectory analysis of a cohort study in Finland
  3. 14043
    “…Benchmark periods over the life course were constructed in three parts: less than 18 years (childhood), 18–35 years (young adults), and 35–50 years (middle-aged). We retrospectively measured financial strains over the life course. …”
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    Influences of Financial Strains Over the Life Course Before Initiating Hemodialysis on Health Outcomes Among Older Japanese Patients: A Retrospective Study in Japan
  4. 14044
    “…BACKGROUND: Spontaneous coronary artery dissection (SCAD) is a frequent cause of acute coronary syndrome in young to middle-aged women with few or no traditional cardiovascular risk factors. …”
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    Spontaneous dissection of proximal left main coronary artery in a healthy adolescent presenting with syncope: A case report
  5. 14045
    “…CONCLUSIONS: In our middle-aged population cohort, we identified 0.2% new AF by single timepoint screening. …”
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    Refined atrial fibrillation screening and cost-effectiveness in the German population
  6. 14046
    “…Furthermore, an inverse dose–response relationship exists between steps taken and risk of premature death and cardiovascular events in middle-aged and older adults. There is a lack of information on how to effectively engage older adults around retirement age in walking. …”
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    A qualitative exploration of attitudes to walking in the retirement life change
  7. 14047
    “…METHODS: The study includes data of N = 213 middle-aged men and women, all diagnosed with myocardial infarction (ICD-10 I21.9) from the region of south-east Sweden. …”
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    Cardiovascular risks before myocardial infarction differences between men and women
  8. 14048
    “…CONCLUSION: Elevated serum SAH, Hcy levels and lower SAM/SAH ratio may be independently associated with the presence of NAFLD in middle-aged and elder Chinese. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12986-022-00647-7.…”
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    Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study
  9. 14049
    “…MATERIALS AND METHODS: Twenty sedentary middle-aged Caucasian women (43.2 ± 7.5 years, BMI = 46.5 ± 5.9 kg·m(−2)) were allocated to a control group (CG, n = 10) that followed solely the conventional preoperative care or to an experimental group (EG, n = 10) that, in addition, performed a 12-week individualized and supervised physical activity program (PAP) that combined aerobic training at Fatmax with low-intensity resistance training. …”
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    A Combination of Aerobic Exercise at Fatmax and Low Resistance Training Increases Fat Oxidation and Maintains Muscle Mass, in Women Waiting for Bariatric Surgery
  10. 14050
    “…In all three phases, the majority of people affected by ocular trauma were middle aged males from a rural background, sustained by assault. …”
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    Impact of the COVID-19-induced lockdown on the incidence of ocular trauma presenting to a tertiary care hospital
  11. 14051
    “…METHOD: We used data from the German Ageing Survey (wave 5 and 6 in the years 2014 and 2017), which is a representative survey of community-dwelling middle-aged and older adults. We included individuals ≥ 65 years (analytical sample: n = 5,682). …”
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    Associations between starting and stopping volunteering and physical activity among older adults - longitudinal evidence from the German Ageing Survey
  12. 14052
    “…Multiple variables, including being middle-aged or of older age, being female, lower levels of education, unemployment, worse general health status, having income difficulties, having unmet needs for healthcare, no healthcare contact during the COVID-19 pandemic, higher mental distress, and loneliness, were significantly associated with lower levels of trust. …”
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    Trust in Healthcare during COVID-19 in Europe: vulnerable groups trust the least
  13. 14053
    por Brunes, Audun, Heir, Trond
    Publicado 2022
    “…Employment was associated with being of middle age, male gender, higher education, residing in high-income municipalities, having a moderate degree of vision loss, lower onset-age of vision loss, and having no additional impairments. …”
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    Visual impairment and employment in Norway
  14. 14054
    “…Herein, PRS for incident prostate cancer was evaluated in two population-based cohorts of unscreened middle-aged men linked to cancer and death registries: the Västerbotten Intervention Project (VIP) and the Malmö Diet and Cancer study (MDC). …”
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    Prostate cancer polygenic risk score and prediction of lethal prostate cancer
  15. 14055
    “…Hence, this study aimed to determine the magnitude and correlates of early onset of multimorbidity and explore its linkages with health-related quality of life (HRQoL) among middle-aged women in India. METHODS: We have utilized data from the first round of the Longitudinal Ageing Study in India, 2017–19. …”
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    Multimorbidity among midlife women in India: well-being beyond reproductive age
  16. 14056
    “…LYPLAL1-AS1 expression in peripheral blood was lower in middle-aged healthy donors than in young adult donors, and correlated negatively with age. …”
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    LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation
  17. 14057
    “…METHODS: In this cross-sectional study, we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020. …”
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    Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease
  18. 14058
    “…CONCLUSIONS: Assessment of frailty/multimorbidity should be embedded within routine management of middle-aged and older people with T2D. Method of identification as well as features such as age impact baseline risk and should influence clinical decisions (e.g. glycaemic control).…”
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    An analysis of frailty and multimorbidity in 20,566 UK Biobank participants with type 2 diabetes
  19. 14059
    “…These findings warrant age-differentiated public health messaging on the risks of excessive alcohol use and scale-up of substance use services for middle-aged and older adults with symptoms of depression and anxiety.…”
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    Increased alcohol use during the COVID-19 pandemic: The effect of mental health and age in a cross-sectional sample of social media users in the U.S.
  20. 14060
    “…DoD mortality risk was highest in middle-aged people; there were rises in all age groups except 15–24 year old males and 65 + females. …”
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    An ecological study of temporal trends in ‘deaths of despair’ in England and Wales
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