“…Here, we investigated the differences in the architecture of TCR beta repertoires for naïve CD4, naïve CD8, naïve CD4(+)CD25(−)CD31(+) (enriched with recent thymic emigrants, RTE), and mature naïve CD4(+)CD25(−)CD31(−) peripheral blood subsets between young and middle-age/old healthy individuals. In addition to observing the accumulation of clonal expansions (as was shown previously), we reveal several notable changes in the characteristics of T cell repertoire. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Increases in street connectivity, residential density, and land-use heterogeneity were associated with walking for transport among middle-age residents of Brisbane, Australia. https://doi.org/10.1289/EHP2080…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The normal aging dataset was divided into 3 age groups: young (20–40 years old), middle-aged (40–60 years old), and elderly (>60 years old). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Likewise, in vivo, ERCC1-deficient mice had transient activation of FOXO3A in early adulthood as did middle-aged wild-type mice, followed by a late life decline. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although epistaxis is usually presented in childhood (mean age 11 ± 7.1 years), gastrointestinal telangiectasia was often encountered in late middle age (mean age 55.4 ± 12.8 years). Bleeding and anemia were the most common complications. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The study was aimed to determine whether lycosome formulated phosphatidylcholine (PC-Lyc) containing two highly bioavailable antioxidants (PC and lycopene) ingested shortly before the alcohol-containing beverage may alleviate the biochemical markers of liver damage and parameters of biological oxidation associated with the intake of a moderate amount of alcohol. Healthy middle-aged volunteers were requested to consume a moderate amount of alcohol – 0.5 ml/kg or 1.0 ml/kg shortly after ingestion of a capsule containing 450 mg of regular phosphatidylcholine (PC, n=10), PC-Lyc (n=10), or placebo pill (PP, n=10). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To investigate this possibility, we used a cross-sectional study design of 100 apparently healthy middle-aged males (n = 48) and females, in which we assessed average dietary intakes of multiple components using a validated questionnaire. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: The data were obtained from a 10-wave (nine-year) longitudinal nationwide survey of middle-aged individuals conducted from 2005 to 2014 in Japan. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Anaemia was prevalent in this study population of middle-aged and older, rural South African adults, but in contrast to high-income countries, it was not associated with poor physical or cognitive function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: In comparison with previous reports, the prevalence and incidence of sarcoidosis in Korea have increased and middle-aged women showed the highest risk. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12931-018-0871-3) contains supplementary material, which is available to authorized users.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Four groups of animals were used: Group 1 (1–3 years old), Group 2 (19–28 years old), Group 3 (10–16 years old), and Group 4 (middle aged, 9–14 years old). Group 4 was exposed to smoke for 1 month. …”
Enlace del recurso
Enlace del recurso

“…METHODS AND RESULTS: Subjects were 108 Japanese community‐dwelling middle‐aged and older adults with preserved ejection fraction (25 men and 83 women; mean age 74.7 years). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Majority of the leopard attack victims in Pauri were children and young people, whereas in North Bengal it was middle aged tea estate workers. Attack on humans in Pauri were recorded mostly near areas with dense scrub cover whereas in North Bengal it was reported within tea-estates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In multivariate analyses, middle age (45–64 years) and baseline anxiety/depression were associated to greater improvement in utility after SVR, and moderate-advanced liver fibrosis and cirrhosis to greater increase in VAS score. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Our study results suggest that appendectomy increases type 2 diabetes risk, particularly when performed prior to middle age.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Differences between patient groups according to age (Adolescents and Young Adults [AYA] 18–39 years, middle-aged 40–64 years, elderly 65 + years) and tumour type (soft-tissue [STS] vs. bone]) were analysed with t-tests or chi-square tests. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Patients from the cohort were predominantly middle-aged (mean ± SD age: 38.5 ± 12.9 years) females (87.6%) with 5.4 ± 2.6 months of disease duration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study we recruited middle-aged adults, as part of a larger study on genetic and environmental contributions to cardiometabolic disease among Africans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The prevalence of diabetes and diabetes risk was found lower compared to population-based study, as majority of the deceased were young and middle-aged males and no females were included. In the case of poisoning with narcotic substances, HbA(1c) was within the reference range. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study confirms the association of poor health behaviors and comorbidities common to middle-aged and older men. The results emphasize the potential scope of targeted gender-sensitized public awareness campaigns and interventions to reduce common male disease, morbidity, and mortality.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso