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  1. 14521
    “…CONCLUSION: MVP is more prevalent in women and middle-aged individuals with normal BMIs in this population. …”
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    Trends in mitral valve prolapse: a tertiary care center experience in Jeddah, Saudi Arabia
  2. 14522
    “…Moreover, in the examination of interactions by age, the association of ambulatory physical activity with IGF-1 levels was only observed in older adults with DM (age ≥ 60 years, β ± SE = 0.23 ± 0.11, p = 0.042) but not in middle-aged adults with DM (age < 60 years, β ± SE = 0.06 ± 0.13, p = 0.645). …”
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    Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study
  3. 14523
    “…For example, it has been shown that a slightly increased BMI (>23 kg/m(2)) at middle age is a risk factor for type 2 diabetes in Asians. …”
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    A body mass index over 22 kg/m(2) at college age is a risk factor for future diabetes in Japanese men
  4. 14524
    “…METHODS: In this retrospective cohort study, we analyzed 8992 middle-aged Japanese subjects (4586 men, 4406 women; mean age, 44.8 ± 9.3 years) without metabolic syndrome from a cohort of employees undergoing annual health examinations. …”
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    Potential impact of the joint association of total bilirubin and gamma-glutamyltransferase with metabolic syndrome
  5. 14525
    “…Subjects: Two thousand six hundred seventy-six middle-aged risk persons without an established cardiovascular or renal disease or type 2 diabetes. …”
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    Awareness of hypertension and depressive symptoms: a cross-sectional study in a primary care population
  6. 14526
    “…Age was also an effect modifier among those without diabetes, however BMI trajectories were more similar among the middle-aged. The subgroup analysis of those without cardiovascular disease, cancer and chronic lung disease showed similar results to the main findings. …”
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    Body mass index trajectories preceding first report of poor self-rated health: A longitudinal case-control analysis of the English Longitudinal Study of Ageing
  7. 14527
    “…This preliminary crosssectional study suggests that foods characteristic of the Southern and Prudent diets may have differential effects on cognitive function in middle-aged individuals at high risk for AD. Results suggest that diet could be a non-pharmaceutical tool to reduce cognitive decline in racially diverse populations. …”
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    Diet as a Risk Factor for Cognitive Decline in African Americans and Caucasians with a Parental History of Alzheimer’s Disease: A Cross-Sectional Pilot Study Dietary Patterns
  8. 14528
    “…Although subject to recall bias, self‐reported weights may provide prognostic information about future HF risk, incremental to current BMI, in a multiethnic cohort of middle‐aged to older adults. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. …”
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    Body Mass Index From Early‐, Mid‐, and Older‐Adulthood and Risk of Heart Failure and Atherosclerotic Cardiovascular Disease: MESA
  9. 14529
    “…CONCLUSIONS: Lung function in young adulthood is independently associated with cardiovascular events into middle age. This association appears to be driven by heart failure and cerebrovascular events rather than coronary heart disease. …”
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    Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study
  10. 14530
    “…To assess efficacy, we used a one-group, pre–post design with overweight/obese, sedentary, middle-aged or older, Spanish-speaking rural Latinas (n = 15). …”
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    Mujeres Fuertes y Corazones Saludables, a Culturally Tailored Physical Activity and Nutrition Program for Rural Latinas: Findings from a Pilot Study
  11. 14531
    “…This study aims to investigate the correlation between oxidative stress and intra-abdominal fat (IAF) in obese young and middle-aged males. The present study included 136 male examinees in the Examination Center of the First Hospital of Qinhuangdao from October 10, 2015 to December 10, 2015. …”
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    The correlation between oxidative stress level and intra-abdominal fat in obese males
  12. 14532
    “…In a cross-sectional study conducted in 3020 middle-aged subjects free of lung disease, adherence to the MedDiet using the Mediterranean Diet Adherence Screener, and physical activity practice using the International Physical Activity Questionnaire short form were recorded. …”
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    Effects of Mediterranean Diet and Physical Activity on Pulmonary Function: A Cross-Sectional Analysis in the ILERVAS Project
  13. 14533
    “…RESULTS: Twenty-four middle-aged persons with diabetes were interviewed. …”
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    Perceptions and Acceptability of Text Messaging for Diabetes Care in Primary Care in Argentina: Exploratory Study
  14. 14534
    “…Conclusion: Promoting exercise intended to improve eCRF may be an important public health initiative aimed at maintaining brain health among middle-aged individuals with and without changing psychological symptoms.…”
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    Associations of Changes in Cardiorespiratory Fitness and Symptoms of Anxiety and Depression With Brain Volumes: The HUNT Study
  15. 14535
    “…Our findings support the conclusion that TLR4 promotes and DAP12 limits HFD‐induced cartilage catabolism in middle‐aged female mice. © 2018 The Authors JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.…”
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    TLR4 Promotes and DAP12 Limits Obesity‐Induced Osteoarthritis in Aged Female Mice
  16. 14536
    “…Background: Erectile dysfunction (ED) after a prostate-transurethral resection (P-TUR) is one of the problems in the treatment of benign prostatic hyperplasia (BPH) that may affect the quality of life in middle-aged and older men. The aim of this study was to investigate the impact of P-TUR on ED in BPH patients. …”
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    The impact of prostate-transurethral resection on erectile dysfunction in benign prostatic hyperplasia
  17. 14537
    “…CONCLUSIONS: Inadequate Ca intake (< 800 mg/day) from the age of 31 to 46 predicts small vertebral size and thus decreased spinal resilience among middle-aged women. Future studies should confirm these findings and investigate the factors underlying the association of low Ca intake in women but not in men with smaller vertebral size. …”
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    Dairy- and supplement-based calcium intake in adulthood and vertebral dimensions in midlife—the Northern Finland Birth Cohort 1966 Study
  18. 14538
    “…Dual opioid and benzodiazepine prescription were highest among those with alcoholic cirrhosis and middle aged-adults. CONCLUSION: Persons with cirrhosis have significantly higher rates of prescription opioid and benzodiazepine prescription compared to others with chronic diseases despite their high risk for adverse drug reactions. …”
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    Opioid and benzodiazepine prescription among patients with cirrhosis compared to other forms of chronic disease
  19. 14539
    “…These correlations were stronger in women than in men (r = 0.649 vs. 0.451 for FRS; r = 0.719 vs. 0.411 for ATP III revised FRS; r = 0.735 vs. 0.540 for generalized FRS; r = 0.699 vs. 0.552 for ACC/AHA CVD risk; p for gender difference ≤ 0.005 for each). CONCLUSIONS: In middle-aged and elderly Koreans without CVD, baPWV was identified as having a moderately positive correlation with four different risk scores. …”
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    Gender difference in the association between brachial-ankle pulse wave velocity and cardiovascular risk scores
  20. 14540
    “…METHODS: We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study. …”
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    Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study
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